Potassium in PDB 7wf3: Composite Map of Human KV1.3 Channel in Apo State with Beta Subunits

The binding sites of Potassium atom in the Composite Map of Human KV1.3 Channel in Apo State with Beta Subunits (pdb code 7wf3). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 4 binding sites of Potassium where determined in the Composite Map of Human KV1.3 Channel in Apo State with Beta Subunits, PDB code: 7wf3:
Jump to Potassium binding site number: 1; 2; 3; 4;

Potassium binding site 1 out of 4 in the Composite Map of Human KV1.3 Channel in Apo State with Beta Subunits


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Composite Map of Human KV1.3 Channel in Apo State with Beta Subunits within 5.0Å range: probe atom residue distance (Å) B Occ B:K501 b:20.0 occ:1.00 CA B:GLY448 4.4 150.7 1.0 CA F:GLY448 4.4 150.7 1.0 CA H:GLY448 4.4 150.7 1.0 CA D:GLY448 4.5 150.7 1.0 O H:GLY446 4.5 139.8 1.0 O B:GLY446 4.5 139.8 1.0 O D:GLY446 4.5 139.8 1.0 O F:GLY446 4.6 139.8 1.0 N B:GLY448 4.6 150.7 1.0 N F:GLY448 4.6 150.7 1.0 N H:GLY448 4.6 150.7 1.0 N D:GLY448 4.7 150.7 1.0 O D:VAL445 4.7 133.7 1.0 C B:GLY446 4.8 139.8 1.0 O H:VAL445 4.8 133.7 1.0 C H:GLY446 4.8 139.8 1.0 O B:VAL445 4.8 133.7 1.0 C D:GLY446 4.8 139.8 1.0 C F:GLY446 4.8 139.8 1.0 O F:VAL445 4.9 133.7 1.0 CA B:GLY446 4.9 139.8 1.0 CA H:GLY446 4.9 139.8 1.0 CA D:GLY446 4.9 139.8 1.0 CA F:GLY446 5.0 139.8 1.0

Potassium binding site 2 out of 4 in the Composite Map of Human KV1.3 Channel in Apo State with Beta Subunits


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Composite Map of Human KV1.3 Channel in Apo State with Beta Subunits within 5.0Å range: probe atom residue distance (Å) B Occ B:K502 b:20.0 occ:1.00 O H:VAL445 2.9 133.7 1.0 O D:VAL445 2.9 133.7 1.0 O B:VAL445 2.9 133.7 1.0 O F:VAL445 2.9 133.7 1.0 O B:THR444 3.4 130.2 1.0 O D:THR444 3.4 130.2 1.0 O H:THR444 3.4 130.2 1.0 O F:THR444 3.4 130.2 1.0 C H:VAL445 3.7 133.7 1.0 C D:VAL445 3.7 133.7 1.0 C B:VAL445 3.7 133.7 1.0 C F:VAL445 3.7 133.7 1.0 K B:K503 4.0 20.0 1.0 CA D:VAL445 4.3 133.7 1.0 CA H:VAL445 4.3 133.7 1.0 CA B:VAL445 4.4 133.7 1.0 C B:THR444 4.4 130.2 1.0 C D:THR444 4.4 130.2 1.0 CA F:VAL445 4.4 133.7 1.0 C H:THR444 4.4 130.2 1.0 C F:THR444 4.4 130.2 1.0 N B:GLY446 4.5 139.8 1.0 N H:GLY446 4.5 139.8 1.0 N F:GLY446 4.5 139.8 1.0 N D:GLY446 4.5 139.8 1.0 CA F:GLY446 4.6 139.8 1.0 CA B:GLY446 4.6 139.8 1.0 CA H:GLY446 4.6 139.8 1.0 CA D:GLY446 4.7 139.8 1.0 N D:VAL445 4.9 133.7 1.0 N B:VAL445 4.9 133.7 1.0 N H:VAL445 4.9 133.7 1.0 N F:VAL445 4.9 133.7 1.0

Potassium binding site 3 out of 4 in the Composite Map of Human KV1.3 Channel in Apo State with Beta Subunits


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Composite Map of Human KV1.3 Channel in Apo State with Beta Subunits within 5.0Å range: probe atom residue distance (Å) B Occ B:K503 b:20.0 occ:1.00 O F:THR444 3.1 130.2 1.0 O H:THR444 3.1 130.2 1.0 O B:THR444 3.1 130.2 1.0 O D:THR444 3.2 130.2 1.0 OG1 B:THR444 3.5 30.0 1.0 OG1 F:THR444 3.5 30.0 1.0 K B:K504 3.6 30.0 1.0 OG1 H:THR444 3.6 30.0 1.0 OG1 D:THR444 3.6 30.0 1.0 CB B:THR444 3.8 30.0 1.0 CB F:THR444 3.9 30.0 1.0 CB H:THR444 3.9 30.0 1.0 CB D:THR444 3.9 30.0 1.0 K B:K502 4.0 20.0 1.0 C B:THR444 4.2 130.2 1.0 C H:THR444 4.2 130.2 1.0 C F:THR444 4.2 130.2 1.0 C D:THR444 4.2 130.2 1.0 CA B:THR444 4.7 130.2 1.0 CA F:THR444 4.7 130.2 1.0 CA H:THR444 4.7 130.2 1.0 CA D:THR444 4.8 130.2 1.0

Potassium binding site 4 out of 4 in the Composite Map of Human KV1.3 Channel in Apo State with Beta Subunits


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Composite Map of Human KV1.3 Channel in Apo State with Beta Subunits within 5.0Å range: probe atom residue distance (Å) B Occ B:K504 b:30.0 occ:1.00 K B:K503 3.6 20.0 1.0 OG1 F:THR444 4.1 30.0 1.0 OG1 H:THR444 4.2 30.0 1.0 OG1 B:THR444 4.2 30.0 1.0 OG1 D:THR444 4.3 30.0 1.0

A.Tyagi, T.Ahmed, S.Jian, S.Bajaj, S.T.Ong, S.S.M.Goay, Y.Zhao, I.Vorobyov, C.Tian, K.G.Chandy, S.Bhushan. Rearrangement of A Unique KV1.3 Selectivity Filter Conformation Upon Binding of A Drug. Proc.Natl.Acad.Sci.Usa V. 119 2022.
ISSN: ESSN 1091-6490
PubMed: 35091471
DOI: 10.1073/PNAS.2113536119