Potassium in PDB 7unm: Human TMEM175 in An Closed State
Potassium Binding Sites:
The binding sites of Potassium atom in the Human TMEM175 in An Closed State
(pdb code 7unm). This binding sites where shown within
5.0 Angstroms radius around Potassium atom.
In total 5 binding sites of Potassium where determined in the
Human TMEM175 in An Closed State, PDB code: 7unm:
Jump to Potassium binding site number:
1;
2;
3;
4;
5;
Potassium binding site 1 out
of 5 in 7unm
Go back to
Potassium Binding Sites List in 7unm
Potassium binding site 1 out
of 5 in the Human TMEM175 in An Closed State
![](/pictures/K/pdb/un/7unm-K-sphere_01.jpg) Mono view
![](/pictures/K/pdb/un/7unm-K-sphere_01_stereo.jpg) Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 1 of Human TMEM175 in An Closed State within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:K701
b:62.7
occ:1.00
|
HB2
|
B:ALA263
|
3.2
|
29.6
|
1.0
|
OG
|
B:SER38
|
3.3
|
28.6
|
1.0
|
HB3
|
B:SER38
|
3.4
|
28.6
|
1.0
|
K
|
A:K602
|
3.4
|
63.3
|
1.0
|
O
|
B:HOH807
|
3.8
|
27.7
|
1.0
|
CB
|
B:SER38
|
3.8
|
28.6
|
1.0
|
HB1
|
B:ALA263
|
3.9
|
29.6
|
1.0
|
HG
|
B:SER38
|
3.9
|
28.6
|
1.0
|
CB
|
B:ALA263
|
4.0
|
29.6
|
1.0
|
HA
|
B:SER38
|
4.0
|
28.6
|
1.0
|
O
|
A:HOH709
|
4.0
|
34.4
|
1.0
|
O
|
B:HOH810
|
4.1
|
34.8
|
1.0
|
O
|
B:HOH823
|
4.2
|
29.8
|
1.0
|
O
|
B:HOH804
|
4.3
|
18.1
|
1.0
|
HB3
|
A:SER38
|
4.5
|
28.4
|
1.0
|
CA
|
B:SER38
|
4.5
|
28.6
|
1.0
|
O
|
B:HOH819
|
4.6
|
24.7
|
1.0
|
HB3
|
B:ALA263
|
4.6
|
29.6
|
1.0
|
HB2
|
B:SER38
|
4.6
|
28.6
|
1.0
|
HA
|
B:ALA263
|
4.6
|
29.6
|
1.0
|
OG
|
A:SER38
|
4.8
|
28.4
|
1.0
|
CA
|
B:ALA263
|
4.9
|
29.6
|
1.0
|
HB2
|
B:GLU259
|
4.9
|
37.3
|
1.0
|
|
Potassium binding site 2 out
of 5 in 7unm
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Potassium Binding Sites List in 7unm
Potassium binding site 2 out
of 5 in the Human TMEM175 in An Closed State
![](/pictures/K/pdb/un/7unm-K-sphere_02.jpg) Mono view
![](/pictures/K/pdb/un/7unm-K-sphere_02_stereo.jpg) Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 2 of Human TMEM175 in An Closed State within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:K601
b:54.9
occ:1.00
|
O
|
B:HOH803
|
2.7
|
22.9
|
1.0
|
O
|
B:HOH817
|
2.7
|
35.7
|
1.0
|
HA2
|
B:GLY267
|
2.7
|
25.3
|
1.0
|
O
|
B:HOH820
|
2.7
|
36.4
|
1.0
|
K
|
A:K603
|
2.7
|
55.3
|
1.0
|
HB1
|
A:ALA42
|
2.9
|
28.9
|
1.0
|
HB2
|
A:ALA42
|
3.0
|
28.9
|
1.0
|
HA3
|
B:GLY267
|
3.3
|
25.3
|
1.0
|
CA
|
B:GLY267
|
3.4
|
25.3
|
1.0
|
CB
|
A:ALA42
|
3.4
|
28.9
|
1.0
|
HA
|
B:ALA42
|
3.5
|
28.9
|
1.0
|
HB2
|
B:ALA42
|
3.5
|
28.9
|
1.0
|
HB1
|
B:ALA42
|
3.7
|
28.9
|
1.0
|
N
|
B:GLY267
|
3.8
|
25.3
|
1.0
|
O
|
A:HOH716
|
3.9
|
35.9
|
1.0
|
HB3
|
A:ALA42
|
4.0
|
28.9
|
1.0
|
CB
|
B:ALA42
|
4.0
|
28.9
|
1.0
|
H
|
B:GLY267
|
4.0
|
25.3
|
1.0
|
O
|
A:HOH719
|
4.2
|
35.6
|
1.0
|
CA
|
B:ALA42
|
4.2
|
28.9
|
1.0
|
O
|
B:HOH804
|
4.4
|
18.1
|
1.0
|
HA
|
A:ALA42
|
4.4
|
28.9
|
1.0
|
C
|
B:ASP266
|
4.5
|
27.8
|
1.0
|
HB3
|
B:ALA270
|
4.5
|
28.8
|
1.0
|
CA
|
A:ALA42
|
4.6
|
28.9
|
1.0
|
O
|
B:HOH819
|
4.6
|
24.7
|
1.0
|
HD11
|
A:ILE46
|
4.6
|
34.6
|
1.0
|
O
|
B:ALA263
|
4.6
|
29.6
|
1.0
|
OG
|
B:SER45
|
4.7
|
28.5
|
1.0
|
O
|
A:HOH702
|
4.7
|
23.0
|
1.0
|
O
|
B:ASP266
|
4.7
|
27.8
|
1.0
|
C
|
B:GLY267
|
4.7
|
25.3
|
1.0
|
HB3
|
B:ASP266
|
4.8
|
27.8
|
1.0
|
O
|
A:HOH704
|
4.8
|
18.6
|
1.0
|
HD11
|
B:ILE46
|
4.8
|
34.5
|
1.0
|
HG
|
B:SER45
|
4.8
|
28.5
|
1.0
|
HB2
|
B:ASP266
|
4.9
|
27.8
|
1.0
|
HB3
|
B:ALA42
|
4.9
|
28.9
|
1.0
|
O
|
B:GLY267
|
5.0
|
25.3
|
1.0
|
|
Potassium binding site 3 out
of 5 in 7unm
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Potassium Binding Sites List in 7unm
Potassium binding site 3 out
of 5 in the Human TMEM175 in An Closed State
![](/pictures/K/pdb/un/7unm-K-sphere_03.jpg) Mono view
![](/pictures/K/pdb/un/7unm-K-sphere_03_stereo.jpg) Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 3 of Human TMEM175 in An Closed State within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:K602
b:63.3
occ:1.00
|
HB2
|
A:ALA263
|
3.2
|
29.6
|
1.0
|
OG
|
A:SER38
|
3.3
|
28.4
|
1.0
|
HB3
|
A:SER38
|
3.4
|
28.4
|
1.0
|
K
|
B:K701
|
3.4
|
62.7
|
1.0
|
O
|
A:HOH706
|
3.8
|
28.1
|
1.0
|
CB
|
A:SER38
|
3.8
|
28.4
|
1.0
|
HB1
|
A:ALA263
|
3.9
|
29.6
|
1.0
|
HG
|
A:SER38
|
4.0
|
28.4
|
1.0
|
CB
|
A:ALA263
|
4.0
|
29.6
|
1.0
|
HA
|
A:SER38
|
4.0
|
28.4
|
1.0
|
O
|
A:HOH709
|
4.0
|
34.4
|
1.0
|
O
|
B:HOH810
|
4.1
|
34.8
|
1.0
|
O
|
A:HOH723
|
4.2
|
29.8
|
1.0
|
O
|
A:HOH704
|
4.3
|
18.6
|
1.0
|
HB3
|
B:SER38
|
4.5
|
28.6
|
1.0
|
CA
|
A:SER38
|
4.5
|
28.4
|
1.0
|
O
|
A:HOH717
|
4.6
|
24.1
|
1.0
|
HB3
|
A:ALA263
|
4.6
|
29.6
|
1.0
|
HB2
|
A:SER38
|
4.6
|
28.4
|
1.0
|
HA
|
A:ALA263
|
4.6
|
29.6
|
1.0
|
OG
|
B:SER38
|
4.8
|
28.6
|
1.0
|
CA
|
A:ALA263
|
4.9
|
29.6
|
1.0
|
HB2
|
A:GLU259
|
4.9
|
37.1
|
1.0
|
|
Potassium binding site 4 out
of 5 in 7unm
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Potassium Binding Sites List in 7unm
Potassium binding site 4 out
of 5 in the Human TMEM175 in An Closed State
![](/pictures/K/pdb/un/7unm-K-sphere_04.jpg) Mono view
![](/pictures/K/pdb/un/7unm-K-sphere_04_stereo.jpg) Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 4 of Human TMEM175 in An Closed State within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:K603
b:55.3
occ:1.00
|
O
|
A:HOH702
|
2.7
|
23.0
|
1.0
|
HA2
|
A:GLY267
|
2.7
|
25.2
|
1.0
|
O
|
A:HOH716
|
2.7
|
35.9
|
1.0
|
O
|
A:HOH719
|
2.7
|
35.6
|
1.0
|
K
|
A:K601
|
2.7
|
54.9
|
1.0
|
HB1
|
B:ALA42
|
2.9
|
28.9
|
1.0
|
HB2
|
B:ALA42
|
3.0
|
28.9
|
1.0
|
HA3
|
A:GLY267
|
3.3
|
25.2
|
1.0
|
CA
|
A:GLY267
|
3.4
|
25.2
|
1.0
|
CB
|
B:ALA42
|
3.4
|
28.9
|
1.0
|
HA
|
A:ALA42
|
3.5
|
28.9
|
1.0
|
HB2
|
A:ALA42
|
3.6
|
28.9
|
1.0
|
HB1
|
A:ALA42
|
3.7
|
28.9
|
1.0
|
N
|
A:GLY267
|
3.8
|
25.2
|
1.0
|
O
|
B:HOH817
|
3.9
|
35.7
|
1.0
|
HB3
|
B:ALA42
|
4.0
|
28.9
|
1.0
|
CB
|
A:ALA42
|
4.0
|
28.9
|
1.0
|
H
|
A:GLY267
|
4.0
|
25.2
|
1.0
|
O
|
B:HOH820
|
4.2
|
36.4
|
1.0
|
CA
|
A:ALA42
|
4.2
|
28.9
|
1.0
|
O
|
A:HOH704
|
4.4
|
18.6
|
1.0
|
HA
|
B:ALA42
|
4.4
|
28.9
|
1.0
|
C
|
A:ASP266
|
4.5
|
27.9
|
1.0
|
HB3
|
A:ALA270
|
4.5
|
29.0
|
1.0
|
CA
|
B:ALA42
|
4.6
|
28.9
|
1.0
|
HD11
|
B:ILE46
|
4.6
|
34.5
|
1.0
|
O
|
A:HOH717
|
4.6
|
24.1
|
1.0
|
O
|
A:ALA263
|
4.6
|
29.6
|
1.0
|
OG
|
A:SER45
|
4.7
|
28.4
|
1.0
|
O
|
B:HOH803
|
4.7
|
22.9
|
1.0
|
O
|
A:ASP266
|
4.7
|
27.9
|
1.0
|
C
|
A:GLY267
|
4.7
|
25.2
|
1.0
|
HB3
|
A:ASP266
|
4.8
|
27.9
|
1.0
|
O
|
B:HOH804
|
4.8
|
18.1
|
1.0
|
HD11
|
A:ILE46
|
4.8
|
34.6
|
1.0
|
HG
|
A:SER45
|
4.8
|
28.4
|
1.0
|
HB2
|
A:ASP266
|
4.9
|
27.9
|
1.0
|
HB3
|
A:ALA42
|
4.9
|
28.9
|
1.0
|
O
|
A:GLY267
|
5.0
|
25.2
|
1.0
|
|
Potassium binding site 5 out
of 5 in 7unm
Go back to
Potassium Binding Sites List in 7unm
Potassium binding site 5 out
of 5 in the Human TMEM175 in An Closed State
![](/pictures/K/pdb/un/7unm-K-sphere_05.jpg) Mono view
![](/pictures/K/pdb/un/7unm-K-sphere_05_stereo.jpg) Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 5 of Human TMEM175 in An Closed State within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:K604
b:59.6
occ:1.00
|
O
|
B:HOH828
|
3.3
|
45.6
|
1.0
|
HD11
|
B:LEU53
|
3.6
|
52.1
|
1.0
|
HD11
|
A:LEU53
|
3.6
|
51.7
|
1.0
|
HD22
|
B:LEU278
|
3.8
|
50.8
|
1.0
|
HD22
|
A:LEU278
|
3.8
|
51.0
|
1.0
|
O
|
A:HOH720
|
3.8
|
40.9
|
1.0
|
O
|
B:HOH821
|
3.8
|
40.5
|
1.0
|
HD21
|
B:LEU278
|
3.9
|
50.8
|
1.0
|
HD21
|
A:LEU278
|
3.9
|
51.0
|
1.0
|
HD21
|
B:LEU275
|
4.0
|
42.1
|
1.0
|
HD21
|
A:LEU275
|
4.0
|
42.2
|
1.0
|
O
|
B:HOH826
|
4.0
|
40.7
|
1.0
|
O
|
A:HOH726
|
4.0
|
40.5
|
1.0
|
HD23
|
B:LEU275
|
4.1
|
42.1
|
1.0
|
HD23
|
A:LEU275
|
4.1
|
42.2
|
1.0
|
CD2
|
B:LEU278
|
4.3
|
50.8
|
1.0
|
CD2
|
A:LEU278
|
4.3
|
51.0
|
1.0
|
CD1
|
B:LEU53
|
4.5
|
52.1
|
1.0
|
CD2
|
B:LEU275
|
4.5
|
42.1
|
1.0
|
CD2
|
A:LEU275
|
4.5
|
42.2
|
1.0
|
CD1
|
A:LEU53
|
4.5
|
51.7
|
1.0
|
HD23
|
B:LEU278
|
4.6
|
50.8
|
1.0
|
HD23
|
A:LEU278
|
4.6
|
51.0
|
1.0
|
HD21
|
B:LEU53
|
4.6
|
52.1
|
1.0
|
HD21
|
A:LEU53
|
4.7
|
51.7
|
1.0
|
HD13
|
B:LEU53
|
4.7
|
52.1
|
1.0
|
HD13
|
A:LEU53
|
4.7
|
51.7
|
1.0
|
HD12
|
B:LEU53
|
4.9
|
52.1
|
1.0
|
HD12
|
A:LEU53
|
4.9
|
51.7
|
1.0
|
|
Reference:
S.Oh,
F.Marinelli,
W.Zhou,
J.Lee,
H.J.Choi,
M.Kim,
J.D.Faraldo-Gomez,
R.K.Hite.
Differential Ion Dehydration Energetics Explains Selectivity in the Non-Canonical Lysosomal K + Channel TMEM175. Elife V. 11 2022.
ISSN: ESSN 2050-084X
PubMed: 35608336
DOI: 10.7554/ELIFE.75122
Page generated: Mon Aug 12 21:23:42 2024
|