Potassium in PDB 7unl: Human TMEM175 in An Open State

The binding sites of Potassium atom in the Human TMEM175 in An Open State (pdb code 7unl). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 8 binding sites of Potassium where determined in the Human TMEM175 in An Open State, PDB code: 7unl:
Jump to Potassium binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Potassium binding site 1 out of 8 in the Human TMEM175 in An Open State


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Human TMEM175 in An Open State within 5.0Å range: probe atom residue distance (Å) B Occ A:K701 b:46.3 occ:1.00 HG A:SER38 2.6 14.5 1.0 OG A:SER38 2.7 14.5 1.0 HG B:SER38 2.8 14.4 1.0 K B:K701 2.8 48.0 1.0 HB2 A:ALA263 3.1 11.1 1.0 O A:HOH845 3.2 21.7 1.0 O B:HOH837 3.3 16.9 1.0 HB1 A:ALA263 3.4 11.1 1.0 OG B:SER38 3.5 14.4 1.0 O A:HOH825 3.6 8.2 1.0 CB A:ALA263 3.7 11.1 1.0 O A:HOH837 3.7 16.6 1.0 HA A:ALA263 3.9 11.1 1.0 O B:HOH855 4.0 13.7 1.0 CB A:SER38 4.1 14.5 1.0 HB3 B:SER38 4.2 14.4 1.0 O A:HOH847 4.3 16.8 1.0 HA A:SER38 4.4 14.5 1.0 HB3 A:SER38 4.4 14.5 1.0 CA A:ALA263 4.4 11.1 1.0 CB B:SER38 4.4 14.4 1.0 HB3 A:ALA263 4.5 11.1 1.0 HB2 A:SER38 4.6 14.5 1.0 HB2 B:SER38 4.8 14.4 1.0 O B:HOH826 4.8 8.2 1.0 CA A:SER38 4.8 14.5 1.0 O A:HOH855 4.8 13.3 1.0 O A:HOH808 4.9 10.2 1.0

Potassium binding site 2 out of 8 in the Human TMEM175 in An Open State


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Human TMEM175 in An Open State within 5.0Å range: probe atom residue distance (Å) B Occ A:K702 b:37.4 occ:1.00 HA2 A:GLY267 2.7 9.3 1.0 O A:HOH819 2.7 8.9 1.0 K B:K702 2.8 37.6 1.0 O A:HOH802 2.9 11.7 1.0 HA3 A:GLY267 2.9 9.3 1.0 O A:HOH844 3.0 9.7 1.0 CA A:GLY267 3.2 9.3 1.0 HA A:ALA42 3.3 11.7 1.0 HB1 B:ALA42 3.3 11.5 1.0 HB2 B:ALA42 3.5 11.5 1.0 HB2 A:ALA42 3.5 11.7 1.0 HB1 A:ALA42 3.6 11.7 1.0 HG A:SER45 3.6 9.4 1.0 CB A:ALA42 3.9 11.7 1.0 CB B:ALA42 3.9 11.5 1.0 N A:GLY267 4.0 9.3 1.0 CA A:ALA42 4.0 11.7 1.0 OG A:SER45 4.0 9.4 1.0 O B:HOH855 4.1 13.7 1.0 H A:GLY267 4.1 9.3 1.0 O B:HOH844 4.1 9.5 1.0 K A:K705 4.3 32.3 1.0 C A:GLY267 4.5 9.3 1.0 O B:HOH802 4.5 10.9 1.0 HB3 B:ALA42 4.5 11.5 1.0 O A:HOH825 4.6 8.2 1.0 HA B:ALA42 4.7 11.5 1.0 O A:GLY267 4.8 9.3 1.0 HB3 A:ALA42 4.8 11.7 1.0 O B:HOH818 4.8 9.1 1.0 O A:ALA263 4.9 11.1 1.0 HB3 A:ALA270 4.9 8.8 1.0 C A:ASP266 4.9 9.8 1.0 O A:ALA42 4.9 11.7 1.0 CA B:ALA42 4.9 11.5 1.0 N A:ALA42 5.0 11.7 1.0 C A:ALA42 5.0 11.7 1.0

Potassium binding site 3 out of 8 in the Human TMEM175 in An Open State


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Human TMEM175 in An Open State within 5.0Å range: probe atom residue distance (Å) B Occ A:K703 b:59.8 occ:1.00 O A:HOH856 2.8 11.2 1.0 O A:HOH857 2.9 11.5 1.0 K B:K703 2.9 60.1 1.0 HD23 B:LEU278 3.1 16.1 1.0 O A:HOH846 3.2 17.4 1.0 HD21 A:LEU53 3.2 20.3 1.0 HD21 B:LEU278 3.2 16.1 1.0 HD11 A:LEU53 3.3 20.3 1.0 CD2 B:LEU278 3.6 16.1 1.0 O B:HOH857 3.7 11.4 1.0 HD22 A:LEU278 3.8 16.2 1.0 HD22 B:LEU278 3.9 16.1 1.0 HD23 A:LEU275 3.9 14.6 1.0 HD23 A:LEU278 3.9 16.2 1.0 CD2 A:LEU53 4.1 20.3 1.0 HG23 A:ILE271 4.2 10.7 1.0 O A:HOH809 4.2 9.3 1.0 CD1 A:LEU53 4.2 20.3 1.0 CD2 A:LEU278 4.2 16.2 1.0 HD21 A:LEU278 4.3 16.2 1.0 HD21 A:LEU275 4.4 14.6 1.0 HD22 A:LEU53 4.5 20.3 1.0 HG21 A:ILE271 4.5 10.7 1.0 O A:HOH807 4.5 10.3 1.0 HD13 A:LEU53 4.5 20.3 1.0 CD2 A:LEU275 4.6 14.6 1.0 O B:HOH856 4.6 11.4 1.0 K A:K704 4.6 23.2 1.0 CG A:LEU53 4.6 20.3 1.0 HG A:LEU53 4.7 20.3 1.0 HD23 A:LEU53 4.7 20.3 1.0 HD22 A:LEU275 4.8 14.6 1.0 CG2 A:ILE271 4.8 10.7 1.0 HD12 A:LEU53 4.9 20.3 1.0 CG B:LEU278 4.9 16.1 1.0 HG B:LEU278 4.9 16.1 1.0 HG12 A:ILE271 5.0 10.7 1.0

Potassium binding site 4 out of 8 in the Human TMEM175 in An Open State


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Human TMEM175 in An Open State within 5.0Å range: probe atom residue distance (Å) B Occ A:K704 b:23.2 occ:1.00 K A:K705 2.8 32.3 1.0 HG12 A:ILE271 2.8 10.7 1.0 HG12 B:ILE271 2.8 10.8 1.0 O B:HOH857 2.9 11.4 1.0 O A:HOH857 2.9 11.5 1.0 HG12 A:ILE46 3.0 11.1 1.0 HG12 B:ILE46 3.0 11.0 1.0 O A:HOH856 3.5 11.2 1.0 O B:HOH856 3.5 11.4 1.0 CG1 A:ILE271 3.7 10.7 1.0 CG1 B:ILE271 3.7 10.8 1.0 HD11 A:ILE271 3.8 10.7 1.0 CG1 A:ILE46 3.8 11.1 1.0 HD11 B:ILE271 3.8 10.8 1.0 CG1 B:ILE46 3.8 11.0 1.0 HG13 A:ILE271 3.8 10.7 1.0 HG13 B:ILE271 3.8 10.8 1.0 HD13 A:ILE46 3.9 11.1 1.0 HD13 B:ILE46 3.9 11.0 1.0 HD11 A:ILE46 3.9 11.1 1.0 HD11 B:ILE46 3.9 11.0 1.0 CD1 A:ILE46 4.1 11.1 1.0 CD1 B:ILE46 4.1 11.0 1.0 CD1 A:ILE271 4.1 10.7 1.0 CD1 B:ILE271 4.1 10.8 1.0 HD13 A:ILE271 4.2 10.7 1.0 HD13 B:ILE271 4.2 10.8 1.0 HG13 A:ILE46 4.2 11.1 1.0 HG13 B:ILE46 4.2 11.0 1.0 HG23 A:ILE46 4.5 11.1 1.0 HG23 B:ILE46 4.5 11.0 1.0 HG21 A:ILE46 4.6 11.1 1.0 HG21 B:ILE46 4.6 11.0 1.0 K A:K703 4.6 59.8 1.0 K B:K703 4.6 60.1 1.0 HA B:ILE271 4.7 10.8 1.0 HA A:ILE271 4.7 10.7 1.0 HG23 A:ILE271 4.7 10.7 1.0 HG23 B:ILE271 4.7 10.8 1.0 HG21 A:ILE271 4.8 10.7 1.0 HG21 B:ILE271 4.8 10.8 1.0 CB A:ILE271 4.9 10.7 1.0 CB B:ILE271 4.9 10.8 1.0 HA A:ILE46 4.9 11.1 1.0 HA B:ILE46 4.9 11.0 1.0 CG2 A:ILE46 4.9 11.1 1.0 CG2 B:ILE46 4.9 11.0 1.0 CB A:ILE46 4.9 11.1 1.0 CB B:ILE46 4.9 11.0 1.0 O A:HOH844 5.0 9.7 1.0 O B:HOH844 5.0 9.5 1.0 O A:HOH802 5.0 11.7 1.0 O B:HOH802 5.0 10.9 1.0

Potassium binding site 5 out of 8 in the Human TMEM175 in An Open State


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 5 of Human TMEM175 in An Open State within 5.0Å range: probe atom residue distance (Å) B Occ A:K705 b:32.3 occ:1.00 K A:K704 2.8 23.2 1.0 O B:HOH844 2.8 9.5 1.0 O A:HOH844 2.8 9.7 1.0 O A:HOH802 2.9 11.7 1.0 O B:HOH802 2.9 10.9 1.0 HD11 A:ILE46 3.1 11.1 1.0 HD11 B:ILE46 3.1 11.0 1.0 HG12 A:ILE46 3.3 11.1 1.0 HG12 B:ILE46 3.3 11.0 1.0 HD11 A:ILE271 3.3 10.7 1.0 HD11 B:ILE271 3.4 10.8 1.0 HG13 A:ILE46 3.5 11.1 1.0 HG13 B:ILE46 3.5 11.0 1.0 HG13 A:ILE271 3.6 10.7 1.0 HG13 B:ILE271 3.6 10.8 1.0 CG1 A:ILE46 3.7 11.1 1.0 CG1 B:ILE46 3.7 11.0 1.0 HG12 A:ILE271 3.7 10.7 1.0 HG12 B:ILE271 3.7 10.8 1.0 CD1 A:ILE46 3.8 11.1 1.0 CD1 B:ILE46 3.8 11.0 1.0 CG1 A:ILE271 4.0 10.7 1.0 CG1 B:ILE271 4.0 10.8 1.0 CD1 A:ILE271 4.1 10.7 1.0 CD1 B:ILE271 4.1 10.8 1.0 HD13 A:ILE46 4.1 11.1 1.0 HD13 B:ILE46 4.1 11.0 1.0 K A:K702 4.3 37.4 1.0 K B:K702 4.3 37.6 1.0 HG A:SER45 4.5 9.4 1.0 HG B:SER45 4.5 9.6 1.0 HD12 A:ILE46 4.5 11.1 1.0 HD12 B:ILE46 4.6 11.0 1.0 HD13 A:ILE271 4.6 10.7 1.0 HD13 B:ILE271 4.6 10.8 1.0 HD12 A:ILE271 4.8 10.7 1.0 HD12 B:ILE271 4.8 10.8 1.0 HB1 A:ALA42 4.8 11.7 1.0 HB1 B:ALA42 4.8 11.5 1.0

Potassium binding site 6 out of 8 in the Human TMEM175 in An Open State


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 6 of Human TMEM175 in An Open State within 5.0Å range: probe atom residue distance (Å) B Occ B:K701 b:48.0 occ:1.00 HG B:SER38 2.5 14.4 1.0 OG B:SER38 2.7 14.4 1.0 K A:K701 2.8 46.3 1.0 HG A:SER38 3.0 14.5 1.0 HB2 B:ALA263 3.1 11.0 1.0 O B:HOH846 3.2 21.7 1.0 O A:HOH837 3.3 16.6 1.0 HB1 B:ALA263 3.4 11.0 1.0 OG A:SER38 3.5 14.5 1.0 O B:HOH826 3.6 8.2 1.0 CB B:ALA263 3.7 11.0 1.0 O B:HOH837 3.7 16.9 1.0 HA B:ALA263 3.9 11.0 1.0 O A:HOH855 4.0 13.3 1.0 CB B:SER38 4.1 14.4 1.0 HB3 A:SER38 4.2 14.5 1.0 O B:HOH848 4.3 17.0 1.0 HA B:SER38 4.4 14.4 1.0 HB3 B:SER38 4.4 14.4 1.0 CA B:ALA263 4.4 11.0 1.0 CB A:SER38 4.4 14.5 1.0 HB3 B:ALA263 4.5 11.0 1.0 HB2 B:SER38 4.6 14.4 1.0 HB2 A:SER38 4.8 14.5 1.0 O A:HOH825 4.8 8.2 1.0 CA B:SER38 4.8 14.4 1.0 O B:HOH855 4.8 13.7 1.0 O B:HOH807 4.9 10.1 1.0

Potassium binding site 7 out of 8 in the Human TMEM175 in An Open State


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 7 of Human TMEM175 in An Open State within 5.0Å range: probe atom residue distance (Å) B Occ B:K702 b:37.6 occ:1.00 HA2 B:GLY267 2.7 9.7 1.0 O B:HOH818 2.7 9.1 1.0 K A:K702 2.8 37.4 1.0 O B:HOH802 2.8 10.9 1.0 HA3 B:GLY267 2.9 9.7 1.0 O B:HOH844 3.0 9.5 1.0 CA B:GLY267 3.2 9.7 1.0 HA B:ALA42 3.3 11.5 1.0 HB1 A:ALA42 3.3 11.7 1.0 HB2 A:ALA42 3.5 11.7 1.0 HB2 B:ALA42 3.5 11.5 1.0 HB1 B:ALA42 3.6 11.5 1.0 HG B:SER45 3.6 9.6 1.0 CB B:ALA42 3.9 11.5 1.0 CB A:ALA42 3.9 11.7 1.0 N B:GLY267 4.0 9.7 1.0 CA B:ALA42 4.0 11.5 1.0 OG B:SER45 4.0 9.6 1.0 O A:HOH855 4.1 13.3 1.0 H B:GLY267 4.1 9.7 1.0 O A:HOH844 4.1 9.7 1.0 K A:K705 4.3 32.3 1.0 C B:GLY267 4.5 9.7 1.0 O A:HOH802 4.5 11.7 1.0 HB3 A:ALA42 4.5 11.7 1.0 O B:HOH826 4.6 8.2 1.0 HA A:ALA42 4.7 11.7 1.0 O B:GLY267 4.8 9.7 1.0 HB3 B:ALA42 4.8 11.5 1.0 O A:HOH819 4.8 8.9 1.0 O B:ALA263 4.9 11.0 1.0 HB3 B:ALA270 4.9 8.8 1.0 C B:ASP266 4.9 9.8 1.0 O B:ALA42 4.9 11.5 1.0 CA A:ALA42 4.9 11.7 1.0 N B:ALA42 5.0 11.5 1.0 C B:ALA42 5.0 11.5 1.0

Potassium binding site 8 out of 8 in the Human TMEM175 in An Open State


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 8 of Human TMEM175 in An Open State within 5.0Å range: probe atom residue distance (Å) B Occ B:K703 b:60.1 occ:1.00 O B:HOH856 2.8 11.4 1.0 O B:HOH857 2.9 11.4 1.0 K A:K703 2.9 59.8 1.0 HD23 A:LEU278 3.1 16.2 1.0 O B:HOH845 3.2 17.2 1.0 HD21 B:LEU53 3.2 20.3 1.0 HD21 A:LEU278 3.2 16.2 1.0 HD11 B:LEU53 3.3 20.3 1.0 CD2 A:LEU278 3.6 16.2 1.0 O A:HOH857 3.7 11.5 1.0 HD22 B:LEU278 3.8 16.1 1.0 HD22 A:LEU278 3.9 16.2 1.0 HD23 B:LEU275 3.9 14.6 1.0 HD23 B:LEU278 4.0 16.1 1.0 CD2 B:LEU53 4.1 20.3 1.0 HG23 B:ILE271 4.2 10.8 1.0 O B:HOH808 4.2 9.2 1.0 CD1 B:LEU53 4.2 20.3 1.0 CD2 B:LEU278 4.2 16.1 1.0 HD21 B:LEU278 4.3 16.1 1.0 HD21 B:LEU275 4.4 14.6 1.0 HD22 B:LEU53 4.5 20.3 1.0 HG21 B:ILE271 4.5 10.8 1.0 O B:HOH805 4.5 10.2 1.0 HD13 B:LEU53 4.5 20.3 1.0 CD2 B:LEU275 4.6 14.6 1.0 O A:HOH856 4.6 11.2 1.0 CG B:LEU53 4.6 20.3 1.0 K A:K704 4.6 23.2 1.0 HG B:LEU53 4.7 20.3 1.0 HD23 B:LEU53 4.7 20.3 1.0 HD22 B:LEU275 4.8 14.6 1.0 CG2 B:ILE271 4.8 10.8 1.0 HD12 B:LEU53 4.9 20.3 1.0 CG A:LEU278 4.9 16.2 1.0 HG A:LEU278 4.9 16.2 1.0 HG12 B:ILE271 5.0 10.8 1.0

S.Oh, F.Marinelli, W.Zhou, J.Lee, H.J.Choi, M.Kim, J.D.Faraldo-Gomez, R.K.Hite. Differential Ion Dehydration Energetics Explains Selectivity in the Non-Canonical Lysosomal K + Channel TMEM175. Elife V. 11 2022.
ISSN: ESSN 2050-084X
PubMed: 35608336
DOI: 10.7554/ELIFE.75122