Potassium in PDB 7ukc: Human KV4.2-KCHIP2 Channel Complex in An Inactivated State, Class 1, Transmembrane Region
Potassium Binding Sites:
The binding sites of Potassium atom in the Human KV4.2-KCHIP2 Channel Complex in An Inactivated State, Class 1, Transmembrane Region
(pdb code 7ukc). This binding sites where shown within
5.0 Angstroms radius around Potassium atom.
In total 4 binding sites of Potassium where determined in the
Human KV4.2-KCHIP2 Channel Complex in An Inactivated State, Class 1, Transmembrane Region, PDB code: 7ukc:
Jump to Potassium binding site number:
1;
2;
3;
4;
Potassium binding site 1 out
of 4 in 7ukc
Go back to
Potassium Binding Sites List in 7ukc
Potassium binding site 1 out
of 4 in the Human KV4.2-KCHIP2 Channel Complex in An Inactivated State, Class 1, Transmembrane Region
![](/pictures/K/pdb/uk/7ukc-K-sphere_01.jpg) Mono view
![](/pictures/K/pdb/uk/7ukc-K-sphere_01_stereo.jpg) Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 1 of Human KV4.2-KCHIP2 Channel Complex in An Inactivated State, Class 1, Transmembrane Region within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:K601
b:31.6
occ:1.00
|
O
|
D:LEU371
|
2.5
|
1.3
|
1.0
|
O
|
A:LEU371
|
2.5
|
1.9
|
1.0
|
O
|
B:LEU371
|
2.5
|
1.3
|
1.0
|
O
|
C:LEU371
|
2.5
|
1.6
|
1.0
|
O
|
B:GLY372
|
2.5
|
1.2
|
1.0
|
O
|
D:GLY372
|
2.6
|
0.8
|
1.0
|
O
|
A:GLY372
|
2.7
|
1.2
|
1.0
|
O
|
C:GLY372
|
2.7
|
1.0
|
1.0
|
K
|
A:K602
|
3.3
|
0.7
|
1.0
|
K
|
A:K603
|
3.4
|
31.6
|
1.0
|
C
|
B:GLY372
|
3.5
|
1.2
|
1.0
|
C
|
D:GLY372
|
3.5
|
0.8
|
1.0
|
C
|
A:GLY372
|
3.6
|
1.2
|
1.0
|
C
|
C:GLY372
|
3.6
|
1.0
|
1.0
|
C
|
D:LEU371
|
3.7
|
1.3
|
1.0
|
C
|
B:LEU371
|
3.7
|
1.3
|
1.0
|
C
|
A:LEU371
|
3.7
|
1.9
|
1.0
|
C
|
C:LEU371
|
3.7
|
1.6
|
1.0
|
CA
|
B:GLY372
|
4.0
|
1.2
|
1.0
|
CA
|
D:GLY372
|
4.0
|
0.8
|
1.0
|
CA
|
A:GLY372
|
4.2
|
1.2
|
1.0
|
CA
|
C:GLY372
|
4.2
|
1.0
|
1.0
|
N
|
D:GLY372
|
4.3
|
0.8
|
1.0
|
N
|
B:GLY372
|
4.3
|
1.2
|
1.0
|
N
|
A:GLY372
|
4.4
|
1.2
|
1.0
|
N
|
C:GLY372
|
4.4
|
1.0
|
1.0
|
N
|
B:TYR373
|
4.5
|
1.5
|
1.0
|
N
|
D:TYR373
|
4.5
|
1.7
|
1.0
|
N
|
A:TYR373
|
4.5
|
1.7
|
1.0
|
N
|
C:TYR373
|
4.5
|
1.3
|
1.0
|
CA
|
A:LEU371
|
4.8
|
1.9
|
1.0
|
CA
|
C:LEU371
|
4.8
|
1.6
|
1.0
|
CA
|
D:LEU371
|
4.8
|
1.3
|
1.0
|
CA
|
B:LEU371
|
4.8
|
1.3
|
1.0
|
CA
|
A:TYR373
|
4.8
|
1.7
|
1.0
|
CA
|
C:TYR373
|
4.8
|
1.3
|
1.0
|
CA
|
B:TYR373
|
4.8
|
1.5
|
1.0
|
CA
|
D:TYR373
|
4.8
|
1.7
|
1.0
|
|
Potassium binding site 2 out
of 4 in 7ukc
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Potassium Binding Sites List in 7ukc
Potassium binding site 2 out
of 4 in the Human KV4.2-KCHIP2 Channel Complex in An Inactivated State, Class 1, Transmembrane Region
![](/pictures/K/pdb/uk/7ukc-K-sphere_02.jpg) Mono view
![](/pictures/K/pdb/uk/7ukc-K-sphere_02_stereo.jpg) Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 2 of Human KV4.2-KCHIP2 Channel Complex in An Inactivated State, Class 1, Transmembrane Region within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:K601
b:31.6
occ:1.00
|
O
|
B:THR370
|
3.0
|
3.2
|
1.0
|
O
|
C:THR370
|
3.0
|
3.6
|
1.0
|
O
|
A:THR370
|
3.0
|
3.9
|
1.0
|
OG1
|
C:THR370
|
3.0
|
3.6
|
1.0
|
OG1
|
A:THR370
|
3.0
|
3.9
|
1.0
|
O
|
D:THR370
|
3.0
|
4.5
|
1.0
|
OG1
|
D:THR370
|
3.0
|
4.5
|
1.0
|
OG1
|
B:THR370
|
3.0
|
3.2
|
1.0
|
CB
|
A:THR370
|
3.5
|
3.9
|
1.0
|
CB
|
C:THR370
|
3.5
|
3.6
|
1.0
|
CB
|
D:THR370
|
3.6
|
4.5
|
1.0
|
CB
|
B:THR370
|
3.6
|
3.2
|
1.0
|
K
|
A:K602
|
3.7
|
0.7
|
1.0
|
C
|
C:THR370
|
4.0
|
3.6
|
1.0
|
C
|
A:THR370
|
4.0
|
3.9
|
1.0
|
C
|
B:THR370
|
4.0
|
3.2
|
1.0
|
C
|
D:THR370
|
4.0
|
4.5
|
1.0
|
CA
|
A:THR370
|
4.4
|
3.9
|
1.0
|
CA
|
C:THR370
|
4.4
|
3.6
|
1.0
|
CA
|
B:THR370
|
4.4
|
3.2
|
1.0
|
CA
|
D:THR370
|
4.4
|
4.5
|
1.0
|
CG2
|
A:THR370
|
4.7
|
3.9
|
1.0
|
CG2
|
C:THR370
|
4.7
|
3.6
|
1.0
|
CG2
|
D:THR370
|
4.7
|
4.5
|
1.0
|
CG2
|
B:THR370
|
4.7
|
3.2
|
1.0
|
O
|
C:THR369
|
4.7
|
5.3
|
1.0
|
O
|
A:THR369
|
4.8
|
6.0
|
1.0
|
O
|
D:THR369
|
4.9
|
4.7
|
1.0
|
O
|
B:THR369
|
4.9
|
3.2
|
1.0
|
CD1
|
A:ILE398
|
4.9
|
38.5
|
1.0
|
CD1
|
C:ILE398
|
4.9
|
37.1
|
1.0
|
|
Potassium binding site 3 out
of 4 in 7ukc
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Potassium Binding Sites List in 7ukc
Potassium binding site 3 out
of 4 in the Human KV4.2-KCHIP2 Channel Complex in An Inactivated State, Class 1, Transmembrane Region
![](/pictures/K/pdb/uk/7ukc-K-sphere_03.jpg) Mono view
![](/pictures/K/pdb/uk/7ukc-K-sphere_03_stereo.jpg) Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 3 of Human KV4.2-KCHIP2 Channel Complex in An Inactivated State, Class 1, Transmembrane Region within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:K602
b:0.7
occ:1.00
|
O
|
C:THR370
|
2.7
|
3.6
|
1.0
|
O
|
A:THR370
|
2.7
|
3.9
|
1.0
|
O
|
B:LEU371
|
2.7
|
1.3
|
1.0
|
O
|
D:THR370
|
2.7
|
4.5
|
1.0
|
O
|
B:THR370
|
2.7
|
3.2
|
1.0
|
O
|
D:LEU371
|
2.7
|
1.3
|
1.0
|
O
|
C:LEU371
|
2.8
|
1.6
|
1.0
|
O
|
A:LEU371
|
2.8
|
1.9
|
1.0
|
K
|
B:K601
|
3.3
|
31.6
|
1.0
|
C
|
B:LEU371
|
3.5
|
1.3
|
1.0
|
C
|
D:LEU371
|
3.5
|
1.3
|
1.0
|
C
|
C:LEU371
|
3.6
|
1.6
|
1.0
|
C
|
A:LEU371
|
3.6
|
1.9
|
1.0
|
K
|
A:K601
|
3.7
|
31.6
|
1.0
|
C
|
A:THR370
|
3.7
|
3.9
|
1.0
|
C
|
C:THR370
|
3.7
|
3.6
|
1.0
|
C
|
D:THR370
|
3.8
|
4.5
|
1.0
|
C
|
B:THR370
|
3.8
|
3.2
|
1.0
|
CA
|
B:LEU371
|
3.8
|
1.3
|
1.0
|
CA
|
D:LEU371
|
3.8
|
1.3
|
1.0
|
CA
|
C:LEU371
|
3.8
|
1.6
|
1.0
|
CA
|
A:LEU371
|
3.8
|
1.9
|
1.0
|
N
|
C:LEU371
|
4.2
|
1.6
|
1.0
|
N
|
A:LEU371
|
4.3
|
1.9
|
1.0
|
N
|
D:LEU371
|
4.3
|
1.3
|
1.0
|
N
|
B:LEU371
|
4.3
|
1.3
|
1.0
|
N
|
B:GLY372
|
4.7
|
1.2
|
1.0
|
N
|
D:GLY372
|
4.7
|
0.8
|
1.0
|
N
|
C:GLY372
|
4.7
|
1.0
|
1.0
|
N
|
A:GLY372
|
4.7
|
1.2
|
1.0
|
CA
|
A:THR370
|
4.9
|
3.9
|
1.0
|
CA
|
C:THR370
|
4.9
|
3.6
|
1.0
|
CA
|
D:THR370
|
4.9
|
4.5
|
1.0
|
CA
|
B:THR370
|
5.0
|
3.2
|
1.0
|
|
Potassium binding site 4 out
of 4 in 7ukc
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Potassium Binding Sites List in 7ukc
Potassium binding site 4 out
of 4 in the Human KV4.2-KCHIP2 Channel Complex in An Inactivated State, Class 1, Transmembrane Region
![](/pictures/K/pdb/uk/7ukc-K-sphere_04.jpg) Mono view
![](/pictures/K/pdb/uk/7ukc-K-sphere_04_stereo.jpg) Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 4 of Human KV4.2-KCHIP2 Channel Complex in An Inactivated State, Class 1, Transmembrane Region within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:K603
b:31.6
occ:1.00
|
O
|
A:TYR373
|
2.6
|
1.7
|
1.0
|
O
|
C:TYR373
|
2.6
|
1.3
|
1.0
|
O
|
B:TYR373
|
2.7
|
1.5
|
1.0
|
O
|
D:TYR373
|
2.7
|
1.7
|
1.0
|
O
|
D:GLY372
|
2.9
|
0.8
|
1.0
|
O
|
B:GLY372
|
2.9
|
1.2
|
1.0
|
O
|
A:GLY372
|
3.0
|
1.2
|
1.0
|
O
|
C:GLY372
|
3.0
|
1.0
|
1.0
|
K
|
B:K601
|
3.4
|
31.6
|
1.0
|
C
|
A:TYR373
|
3.4
|
1.7
|
1.0
|
C
|
C:TYR373
|
3.4
|
1.3
|
1.0
|
C
|
B:TYR373
|
3.4
|
1.5
|
1.0
|
C
|
D:TYR373
|
3.4
|
1.7
|
1.0
|
CA
|
D:TYR373
|
4.0
|
1.7
|
1.0
|
CA
|
B:TYR373
|
4.0
|
1.5
|
1.0
|
C
|
D:GLY372
|
4.0
|
0.8
|
1.0
|
CA
|
A:TYR373
|
4.0
|
1.7
|
1.0
|
CA
|
C:TYR373
|
4.0
|
1.3
|
1.0
|
C
|
B:GLY372
|
4.0
|
1.2
|
1.0
|
C
|
A:GLY372
|
4.1
|
1.2
|
1.0
|
C
|
C:GLY372
|
4.1
|
1.0
|
1.0
|
N
|
B:GLY374
|
4.3
|
1.6
|
1.0
|
N
|
D:GLY374
|
4.3
|
6.3
|
1.0
|
N
|
A:GLY374
|
4.3
|
2.2
|
1.0
|
N
|
C:GLY374
|
4.3
|
1.9
|
1.0
|
N
|
D:TYR373
|
4.5
|
1.7
|
1.0
|
N
|
B:TYR373
|
4.5
|
1.5
|
1.0
|
CA
|
A:GLY374
|
4.6
|
2.2
|
1.0
|
CA
|
C:GLY374
|
4.6
|
1.9
|
1.0
|
N
|
A:TYR373
|
4.6
|
1.7
|
1.0
|
N
|
C:TYR373
|
4.6
|
1.3
|
1.0
|
CA
|
B:GLY374
|
4.6
|
1.6
|
1.0
|
CA
|
D:GLY374
|
4.6
|
6.3
|
1.0
|
|
Reference:
W.Ye,
H.Zhao,
Y.Dai,
Y.Wang,
Y.H.Lo,
L.Y.Jan,
C.H.Lee.
Activation and Closed-State Inactivation Mechanisms of the Human Voltage-Gated K V 4 Channel Complexes. Mol.Cell V. 82 2427 2022.
ISSN: ISSN 1097-2765
PubMed: 35597238
DOI: 10.1016/J.MOLCEL.2022.04.032
Page generated: Mon Aug 12 21:20:45 2024
|