Potassium in PDB 7tth: Human Potassium-Chloride Cotransporter 1 in Inward-Open State

The binding sites of Potassium atom in the Human Potassium-Chloride Cotransporter 1 in Inward-Open State (pdb code 7tth). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Human Potassium-Chloride Cotransporter 1 in Inward-Open State, PDB code: 7tth:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in the Human Potassium-Chloride Cotransporter 1 in Inward-Open State


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Human Potassium-Chloride Cotransporter 1 in Inward-Open State within 5.0Å range: probe atom residue distance (Å) B Occ A:K1101 b:30.0 occ:1.00 O A:THR432 2.9 84.5 1.0 O A:PRO429 3.1 82.6 1.0 O A:ILE132 3.1 92.7 1.0 OG1 A:THR432 3.5 84.5 1.0 O A:ASN131 3.6 96.8 1.0 OH A:TYR216 3.8 88.5 1.0 C A:THR432 3.9 84.5 1.0 C A:ILE132 3.9 92.7 1.0 N A:THR432 4.2 84.5 1.0 CA A:ILE132 4.2 92.7 1.0 C A:PRO429 4.3 82.6 1.0 CA A:THR432 4.4 84.5 1.0 C A:SER430 4.5 86.2 1.0 CB A:THR432 4.6 84.5 1.0 O A:PHE133 4.6 91.8 1.0 C A:ASN131 4.6 96.8 1.0 CA A:SER430 4.6 86.2 1.0 N A:VAL431 4.7 82.5 1.0 C A:PHE133 4.7 91.8 1.0 CA A:GLY134 4.8 87.4 1.0 C A:VAL431 4.8 82.5 1.0 N A:GLY134 4.8 87.4 1.0 O A:SER430 4.8 86.2 1.0 OD1 A:ASN131 4.9 96.8 1.0 N A:GLY433 4.9 88.2 1.0 N A:PHE133 4.9 91.8 1.0 N A:SER430 5.0 86.2 1.0 N A:ILE132 5.0 92.7 1.0

Potassium binding site 2 out of 2 in the Human Potassium-Chloride Cotransporter 1 in Inward-Open State


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Human Potassium-Chloride Cotransporter 1 in Inward-Open State within 5.0Å range: probe atom residue distance (Å) B Occ B:K1101 b:30.0 occ:1.00 O B:THR432 2.9 84.9 1.0 O B:PRO429 3.1 81.9 1.0 O B:ILE132 3.1 91.5 1.0 OG1 B:THR432 3.5 84.9 1.0 O B:ASN131 3.7 95.4 1.0 OH B:TYR216 3.8 86.5 1.0 C B:THR432 3.9 84.9 1.0 C B:ILE132 3.9 91.5 1.0 N B:THR432 4.2 84.9 1.0 CA B:ILE132 4.3 91.5 1.0 C B:PRO429 4.3 81.9 1.0 CA B:THR432 4.4 84.9 1.0 C B:SER430 4.5 85.3 1.0 CB B:THR432 4.6 84.9 1.0 CA B:SER430 4.6 85.3 1.0 N B:VAL431 4.7 82.3 1.0 O B:PHE133 4.7 90.7 1.0 C B:PHE133 4.7 90.7 1.0 C B:ASN131 4.7 95.4 1.0 C B:VAL431 4.8 82.3 1.0 CA B:GLY134 4.8 87.8 1.0 O B:SER430 4.8 85.3 1.0 N B:GLY134 4.8 87.8 1.0 OD1 B:ASN131 4.9 95.4 1.0 N B:GLY433 4.9 88.6 1.0 N B:SER430 5.0 85.3 1.0 N B:PHE133 5.0 90.7 1.0

Y.Zhao, J.Shen, Q.Wang, M.J.Ruiz Munevar, P.Vidossich, M.De Vivo, M.Zhou, E.Cao. Structure of the Human Cation-Chloride Cotransport KCC1 in An Outward-Open State. Proc.Natl.Acad.Sci.Usa V. 119 83119 2022.
ISSN: ESSN 1091-6490
PubMed: 35759661
DOI: 10.1073/PNAS.2109083119