Potassium in PDB 7p5t: Structure of CYP142 From Mycobacterium Tuberculosis in Complex with Inhibitor MEK216

All present enzymatic activity of Structure of CYP142 From Mycobacterium Tuberculosis in Complex with Inhibitor MEK216:
1.14.15.28;

The structure of Structure of CYP142 From Mycobacterium Tuberculosis in Complex with Inhibitor MEK216, PDB code: 7p5t was solved by M.Snee, M.Kavanagh, R.Tunnicliffe, K.Mclean, C.Levy, A.Munro, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	64.53 / 1.30
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	55.728, 65.717, 129.069, 90, 90, 90
R / Rfree (%)	13.7 / 16.2

The structure of Structure of CYP142 From Mycobacterium Tuberculosis in Complex with Inhibitor MEK216 also contains other interesting chemical elements:

Iron	(Fe)	1 atom
Bromine	(Br)	3 atoms

The binding sites of Potassium atom in the Structure of CYP142 From Mycobacterium Tuberculosis in Complex with Inhibitor MEK216 (pdb code 7p5t). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Structure of CYP142 From Mycobacterium Tuberculosis in Complex with Inhibitor MEK216, PDB code: 7p5t:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in the Structure of CYP142 From Mycobacterium Tuberculosis in Complex with Inhibitor MEK216


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Structure of CYP142 From Mycobacterium Tuberculosis in Complex with Inhibitor MEK216 within 5.0Å range: probe atom residue distance (Å) B Occ A:K406 b:31.9 occ:1.00 O A:HOH899 3.0 46.2 1.0 N A:GLU319 3.2 16.8 1.0 C A:GLU317 3.5 16.9 1.0 CD A:PRO318 3.5 18.3 1.0 N A:PRO318 3.5 16.9 1.0 CB A:GLU319 3.5 18.6 1.0 CA A:GLU317 3.5 17.6 0.5 CA A:GLU317 3.6 17.5 0.5 CG A:GLU317 3.7 20.3 0.5 CA A:GLU319 3.8 17.6 1.0 O A:GLU317 4.0 17.0 1.0 CG A:GLU319 4.0 21.8 1.0 CB A:GLU317 4.1 19.5 0.5 CG A:PRO318 4.1 19.5 1.0 CB A:GLU317 4.2 19.3 0.5 C A:PRO318 4.2 16.4 1.0 C A:GLU319 4.4 17.1 1.0 CA A:PRO318 4.4 17.4 1.0 N A:LYS320 4.5 16.5 1.0 O A:HOH1070 4.5 55.0 1.0 CG A:GLU317 4.5 20.8 0.5 O A:HOH1051 4.7 80.9 1.0 N A:GLU317 4.8 17.1 1.0 CB A:PRO318 5.0 17.6 1.0

Potassium binding site 2 out of 2 in the Structure of CYP142 From Mycobacterium Tuberculosis in Complex with Inhibitor MEK216


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Structure of CYP142 From Mycobacterium Tuberculosis in Complex with Inhibitor MEK216 within 5.0Å range: probe atom residue distance (Å) B Occ A:K407 b:19.7 occ:0.70 NE1 A:TRP155 3.3 19.1 1.0 CG A:MET151 3.5 20.7 0.3 SD A:MET151 3.7 22.0 0.3 SD A:MET151 3.8 24.5 0.7 CG A:MET151 3.9 22.1 0.7 CE2 A:TRP155 4.1 19.5 1.0 CZ2 A:TRP155 4.2 19.5 1.0 CD1 A:TRP155 4.4 19.1 1.0

M.Kavanagh, A.Coyne. Structure of CYP142 From Mycobacterium Tuberculosis in Complex with Inhibitor MEK216 To Be Published.