Potassium in PDB 7ozz: The Crystal Structure of A Dna:Rna Hybrid Duplex Sequence Cttttctttg with Lna-Amide Modification

The structure of The Crystal Structure of A Dna:Rna Hybrid Duplex Sequence Cttttctttg with Lna-Amide Modification, PDB code: 7ozz was solved by C.Thorpe, J.Hardwick, M.A.Mcdonough, J.P.Hall, Y.R.Baker, A.H.El-Sagheer, T.Brown, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	27.06 / 2.70
Space group	P 61
Cell size a, b, c (Å), α, β, γ (°)	54.12, 54.12, 48.84, 90, 90, 120
R / Rfree (%)	20 / 23.7

The binding sites of Potassium atom in the The Crystal Structure of A Dna:Rna Hybrid Duplex Sequence Cttttctttg with Lna-Amide Modification (pdb code 7ozz). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total only one binding site of Potassium was determined in the The Crystal Structure of A Dna:Rna Hybrid Duplex Sequence Cttttctttg with Lna-Amide Modification, PDB code: 7ozz:

Potassium binding site 1 out of 1 in the The Crystal Structure of A Dna:Rna Hybrid Duplex Sequence Cttttctttg with Lna-Amide Modification


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of The Crystal Structure of A Dna:Rna Hybrid Duplex Sequence Cttttctttg with Lna-Amide Modification within 5.0Å range: probe atom residue distance (Å) B Occ A:K101 b:152.7 occ:1.00 O6 A:G10 4.1 94.5 1.0 N7 A:A9 4.2 98.8 1.0 N7 A:G10 4.3 93.9 1.0 N6 A:A9 4.7 94.4 1.0 C6 A:G10 4.9 87.7 1.0 C5 A:A9 5.0 93.8 1.0

Y.R.Baker, C.Thorpe, J.Chen, L.M.Poller, L.Cox, P.Kumar, W.F.Lim, L.Lie, G.Mcclorey, S.Epple, D.Singleton, M.A.Mcdonough, J.S.Hardwick, K.E.Christensen, M.J.A.Wood, J.P.Hall, A.H.El-Sagheer, T.Brown. An Lna-Amide Modification That Enhances the Cell Uptake and Activity of Phosphorothioate Exon-Skipping Oligonucleotides. Nat Commun V. 13 4036 2022.
ISSN: ESSN 2041-1723
PubMed: 35821218
DOI: 10.1038/S41467-022-31636-2