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Potassium in PDB 7jz7: Dihydrodipicolinate Synthase Mutant S48F

Enzymatic activity of Dihydrodipicolinate Synthase Mutant S48F

All present enzymatic activity of Dihydrodipicolinate Synthase Mutant S48F:
4.3.3.7;

Protein crystallography data

The structure of Dihydrodipicolinate Synthase Mutant S48F, PDB code: 7jz7 was solved by A.J.Board, R.C.J.Dobson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 32.17 / 1.74
Space group P 31 2 1
Cell size a, b, c (Å), α, β, γ (°) 120.729, 120.729, 110.812, 90, 90, 120
R / Rfree (%) 14.9 / 17.2

Potassium Binding Sites:

The binding sites of Potassium atom in the Dihydrodipicolinate Synthase Mutant S48F (pdb code 7jz7). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 4 binding sites of Potassium where determined in the Dihydrodipicolinate Synthase Mutant S48F, PDB code: 7jz7:
Jump to Potassium binding site number: 1; 2; 3; 4;

Potassium binding site 1 out of 4 in 7jz7

Go back to Potassium Binding Sites List in 7jz7
Potassium binding site 1 out of 4 in the Dihydrodipicolinate Synthase Mutant S48F


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Dihydrodipicolinate Synthase Mutant S48F within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K301

b:24.8
occ:1.00
 O A:ILE157 2.6 19.8 1.0
O A:ALA152 2.7 22.6 1.0
O A:HOH624 2.7 37.3 1.0
O A:VAL154 2.7 23.5 1.0
O A:HOH650 2.9 46.7 1.0
O A:LYS155 3.1 24.2 1.0
C A:LYS155 3.6 24.8 1.0
C A:ILE157 3.7 17.9 1.0
C A:VAL154 3.7 22.1 1.0
C A:ALA152 3.7 23.1 1.0
CA A:LYS155 4.0 26.8 1.0
N A:ILE157 4.1 18.3 1.0
N A:LYS155 4.3 25.1 1.0
CA A:ILE157 4.4 17.6 1.0
CA A:ALA152 4.4 18.4 1.0
N A:ASN156 4.6 23.7 1.0
N A:VAL154 4.6 22.7 1.0
C A:LYS153 4.6 30.0 1.0
N A:ILE158 4.6 16.9 1.0
CA A:ILE158 4.7 19.6 1.0
N A:LYS153 4.7 20.1 1.0
CG2 A:ILE158 4.8 31.6 1.0
CA A:VAL154 4.8 23.2 1.0
CB A:ILE157 4.9 18.6 1.0
CA A:LYS153 4.9 25.2 1.0
C A:ASN156 4.9 22.1 1.0
O A:LYS153 5.0 27.1 1.0
CD1 A:PHE181 5.0 21.2 1.0

Potassium binding site 2 out of 4 in 7jz7

Go back to Potassium Binding Sites List in 7jz7
Potassium binding site 2 out of 4 in the Dihydrodipicolinate Synthase Mutant S48F


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Dihydrodipicolinate Synthase Mutant S48F within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K304

b:26.6
occ:1.00
 OD1 A:ASN80 2.6 18.1 1.0
O B:ALA49 2.6 26.7 1.0
OE1 A:GLU84 2.6 34.8 1.0
O B:HOH618 2.8 33.4 1.0
O A:HOH653 3.1 35.1 1.0
O A:HOH577 3.5 44.7 1.0
O A:HOH403 3.5 35.5 1.0
O B:HOH401 3.5 39.5 1.0
O A:HOH568 3.5 30.2 1.0
C B:ALA49 3.7 24.5 1.0
CD A:GLU84 3.7 33.8 1.0
CG A:ASN80 3.8 16.0 1.0
OE2 A:GLU84 4.1 33.1 1.0
CA B:ALA49 4.2 23.7 1.0
ND2 A:ASN80 4.2 15.1 1.0
CB A:ALA81 4.4 14.9 1.0
N A:ALA81 4.6 15.4 1.0
N B:THR50 4.8 19.8 1.0
N A:ASN80 4.9 15.8 1.0
O B:HOH663 4.9 32.8 1.0
CB B:ALA49 4.9 24.4 1.0
C A:ASN80 4.9 17.4 1.0
O B:PHE48 5.0 24.6 1.0

Potassium binding site 3 out of 4 in 7jz7

Go back to Potassium Binding Sites List in 7jz7
Potassium binding site 3 out of 4 in the Dihydrodipicolinate Synthase Mutant S48F


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Dihydrodipicolinate Synthase Mutant S48F within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K301

b:20.4
occ:1.00
 O B:ILE157 2.7 16.0 1.0
O B:ALA152 2.7 16.8 1.0
O B:HOH659 2.7 31.3 1.0
O B:VAL154 2.7 22.4 1.0
O B:HOH657 2.8 45.5 1.0
O B:LYS155 3.2 21.5 1.0
C B:LYS155 3.7 20.5 1.0
C B:ILE157 3.7 14.8 1.0
C B:ALA152 3.7 15.8 1.0
C B:VAL154 3.8 23.4 1.0
CA B:LYS155 4.0 24.7 1.0
N B:ILE157 4.1 15.5 1.0
O B:HOH590 4.3 39.1 1.0
N B:LYS155 4.3 21.4 1.0
CA B:ALA152 4.4 14.6 1.0
CA B:ILE157 4.5 15.1 1.0
N B:VAL154 4.6 21.4 1.0
N B:ASN156 4.6 18.6 1.0
N B:ILE158 4.6 14.5 1.0
C B:LYS153 4.6 24.1 1.0
CA B:ILE158 4.7 15.2 1.0
N B:LYS153 4.8 16.4 1.0
CA B:VAL154 4.8 21.3 1.0
CD1 B:PHE181 4.9 14.2 1.0
O B:LYS153 4.9 22.9 1.0
CB B:ILE157 4.9 13.9 1.0
CA B:LYS153 4.9 19.2 1.0
C B:ASN156 5.0 15.4 1.0

Potassium binding site 4 out of 4 in 7jz7

Go back to Potassium Binding Sites List in 7jz7
Potassium binding site 4 out of 4 in the Dihydrodipicolinate Synthase Mutant S48F


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Dihydrodipicolinate Synthase Mutant S48F within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K305

b:26.0
occ:1.00
 OE1 B:GLU84 2.6 35.8 1.0
O A:ALA49 2.6 17.5 1.0
OD1 B:ASN80 2.6 15.0 1.0
O A:HOH534 2.7 39.1 1.0
O A:HOH410 2.9 33.1 1.0
O B:HOH663 3.1 32.8 1.0
O B:HOH585 3.6 24.7 1.0
O B:HOH616 3.6 45.6 1.0
C A:ALA49 3.7 17.3 1.0
CG B:ASN80 3.7 17.4 1.0
O B:HOH413 3.7 29.3 1.0
CD B:GLU84 3.8 42.1 1.0
OE2 B:GLU84 4.1 40.4 1.0
ND2 B:ASN80 4.2 14.9 1.0
CA A:ALA49 4.3 17.8 1.0
CB B:ALA81 4.3 17.2 1.0
O A:HOH645 4.4 39.9 1.0
N B:ALA81 4.6 13.8 1.0
N A:THR50 4.7 13.8 1.0
O A:HOH653 4.9 35.1 1.0
O A:PHE48 4.9 16.4 1.0
O A:HOH626 4.9 31.9 1.0
CA A:THR50 5.0 13.8 1.0
CB A:ALA49 5.0 18.4 1.0
C B:ASN80 5.0 17.0 1.0
N B:ASN80 5.0 15.1 1.0
CB B:ASN80 5.0 16.2 1.0

Reference:

A.J.Board, R.C.J.Dobson. Mapping the Unchartered Waters of Dihydrodipicolinate Synthase: A Novel Mechanism of Allosteric Inhibition. To Be Published.
Page generated: Mon Aug 12 19:10:52 2024

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