Atomistry » Potassium » PDB 7g6s-7jvu » 7g74
Atomistry »
  Potassium »
    PDB 7g6s-7jvu »
      7g74 »

Potassium in PDB 7g74: Crystal Structure of Rat Autotaxin in Complex with 4-[[4-[[6-(4- Acetylpiperazin-1-Yl)-4-Oxoquinazolin-3-Yl]Methyl]Triazol-1- Yl]Methyl]-2-Fluorobenzonitrile

Enzymatic activity of Crystal Structure of Rat Autotaxin in Complex with 4-[[4-[[6-(4- Acetylpiperazin-1-Yl)-4-Oxoquinazolin-3-Yl]Methyl]Triazol-1- Yl]Methyl]-2-Fluorobenzonitrile

All present enzymatic activity of Crystal Structure of Rat Autotaxin in Complex with 4-[[4-[[6-(4- Acetylpiperazin-1-Yl)-4-Oxoquinazolin-3-Yl]Methyl]Triazol-1- Yl]Methyl]-2-Fluorobenzonitrile:
3.1.4.39;

Protein crystallography data

The structure of Crystal Structure of Rat Autotaxin in Complex with 4-[[4-[[6-(4- Acetylpiperazin-1-Yl)-4-Oxoquinazolin-3-Yl]Methyl]Triazol-1- Yl]Methyl]-2-Fluorobenzonitrile, PDB code: 7g74 was solved by M.Stihle, J.Benz, D.Hunziker, E.Martin-Rainer, M.G.Rudolph, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 48.98 / 1.82
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 84.472, 92.279, 120.246, 90, 90, 90
R / Rfree (%) 18.2 / 22.2

Other elements in 7g74:

The structure of Crystal Structure of Rat Autotaxin in Complex with 4-[[4-[[6-(4- Acetylpiperazin-1-Yl)-4-Oxoquinazolin-3-Yl]Methyl]Triazol-1- Yl]Methyl]-2-Fluorobenzonitrile also contains other interesting chemical elements:

Fluorine (F) 1 atom
Sodium (Na) 1 atom
Calcium (Ca) 2 atoms
Zinc (Zn) 1 atom
Chlorine (Cl) 1 atom

Potassium Binding Sites:

The binding sites of Potassium atom in the Crystal Structure of Rat Autotaxin in Complex with 4-[[4-[[6-(4- Acetylpiperazin-1-Yl)-4-Oxoquinazolin-3-Yl]Methyl]Triazol-1- Yl]Methyl]-2-Fluorobenzonitrile (pdb code 7g74). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total only one binding site of Potassium was determined in the Crystal Structure of Rat Autotaxin in Complex with 4-[[4-[[6-(4- Acetylpiperazin-1-Yl)-4-Oxoquinazolin-3-Yl]Methyl]Triazol-1- Yl]Methyl]-2-Fluorobenzonitrile, PDB code: 7g74:

Potassium binding site 1 out of 1 in 7g74

Go back to Potassium Binding Sites List in 7g74
Potassium binding site 1 out of 1 in the Crystal Structure of Rat Autotaxin in Complex with 4-[[4-[[6-(4- Acetylpiperazin-1-Yl)-4-Oxoquinazolin-3-Yl]Methyl]Triazol-1- Yl]Methyl]-2-Fluorobenzonitrile


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of Rat Autotaxin in Complex with 4-[[4-[[6-(4- Acetylpiperazin-1-Yl)-4-Oxoquinazolin-3-Yl]Methyl]Triazol-1- Yl]Methyl]-2-Fluorobenzonitrile within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K909

b:34.6
occ:1.00
 O A:ASP672 2.3 29.1 1.0
O A:MET675 2.4 29.6 1.0
O A:TYR669 2.5 29.0 1.0
O A:HOH1548 2.5 31.9 1.0
O A:HOH1285 2.5 35.9 1.0
O A:HOH1578 3.0 38.2 1.0
C A:MET675 3.5 30.1 1.0
C A:ASP672 3.5 30.3 1.0
C A:TYR669 3.6 29.7 1.0
N A:MET675 4.1 31.5 1.0
N A:SER676 4.3 24.6 1.0
CA A:LYS673 4.3 34.9 1.0
CA A:SER676 4.3 24.6 1.0
O A:LYS670 4.3 33.0 1.0
N A:LYS673 4.4 31.2 1.0
CA A:TYR669 4.4 27.7 1.0
CA A:MET675 4.4 28.4 1.0
CA A:ASP672 4.4 30.6 1.0
C A:LYS673 4.5 34.4 1.0
N A:ASP672 4.5 35.4 1.0
N A:LYS670 4.5 32.5 1.0
CB A:ASP672 4.6 30.7 1.0
C A:LYS670 4.6 28.5 1.0
CA A:LYS670 4.7 31.2 1.0
O A:LYS673 4.7 37.9 1.0
CB A:TYR669 4.8 25.7 1.0
N A:GLN674 4.8 34.8 1.0
CB A:SER676 4.9 25.0 1.0
C A:GLN674 4.9 32.7 1.0

Reference:

D.Hunziker, S.C.Joachim, C.Ullmer, M.G.Rudolph. Crystal Structure of A Rat Autotaxin Complex To Be Published.
Page generated: Sat Feb 8 20:05:55 2025

Last articles

Mg in 9IXM
Mg in 9H5P
Mg in 9IW3
Mg in 9IJ4
Mg in 9FSF
Mg in 9FS8
Mg in 9FY0
Mg in 9G0R
Mg in 9G0T
Mg in 9G0O
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy