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Potassium in PDB 7fs0: Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 8
Enzymatic activity of Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 8
All present enzymatic activity of Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 8:
2.7.1.40;
2.7.1.40;
Protein crystallography data
The structure of Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 8, PDB code: 7fs0
was solved by
A.Lulla,
O.Nilsson,
P.Brear,
A.Nain-Perez,
M.Grotli,
M.Hyvonen,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 189.45 / 2.41 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 209.002, 113.344, 189.484, 90, 91.12, 90 |
| R / Rfree (%) | 21.9 / 25.3 |
Other elements in 7fs0:
The structure of Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 8 also contains other interesting chemical elements:
| Magnesium | (Mg) | 8 atoms |
Potassium Binding Sites:
The binding sites of Potassium atom in the Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 8
(pdb code 7fs0). This binding sites where shown within
5.0 Angstroms radius around Potassium atom.
In total 8 binding sites of Potassium where determined in the Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 8, PDB code: 7fs0:
Jump to Potassium binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
In total 8 binding sites of Potassium where determined in the Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 8, PDB code: 7fs0:
Jump to Potassium binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
Potassium binding site 1 out of 8 in 7fs0
Go back to
Potassium Binding Sites List in 7fs0
Potassium binding site 1 out
of 8 in the Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 8
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 1 of Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 8 within 5.0Å range:
|
Potassium binding site 2 out of 8 in 7fs0
Go back to
Potassium Binding Sites List in 7fs0
Potassium binding site 2 out
of 8 in the Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 8
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 2 of Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 8 within 5.0Å range:
|
Potassium binding site 3 out of 8 in 7fs0
Go back to
Potassium Binding Sites List in 7fs0
Potassium binding site 3 out
of 8 in the Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 8
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 3 of Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 8 within 5.0Å range:
|
Potassium binding site 4 out of 8 in 7fs0
Go back to
Potassium Binding Sites List in 7fs0
Potassium binding site 4 out
of 8 in the Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 8
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 4 of Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 8 within 5.0Å range:
|
Potassium binding site 5 out of 8 in 7fs0
Go back to
Potassium Binding Sites List in 7fs0
Potassium binding site 5 out
of 8 in the Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 8
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 5 of Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 8 within 5.0Å range:
|
Potassium binding site 6 out of 8 in 7fs0
Go back to
Potassium Binding Sites List in 7fs0
Potassium binding site 6 out
of 8 in the Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 8
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 6 of Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 8 within 5.0Å range:
|
Potassium binding site 7 out of 8 in 7fs0
Go back to
Potassium Binding Sites List in 7fs0
Potassium binding site 7 out
of 8 in the Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 8
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 7 of Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 8 within 5.0Å range:
|
Potassium binding site 8 out of 8 in 7fs0
Go back to
Potassium Binding Sites List in 7fs0
Potassium binding site 8 out
of 8 in the Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 8
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 8 of Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 8 within 5.0Å range:
|
Reference:
A.Nain-Perez,
O.Nilsson,
A.Lulla,
L.Haversen,
P.Brear,
S.Liljenberg,
M.Hyvonen,
J.Boren,
M.Grotli.
Tuning Liver Pyruvate Kinase Activity Up or Down with A New Class of Allosteric Modulators. Eur.J.Med.Chem. V. 250 15177 2023.
ISSN: ISSN 0223-5234
PubMed: 36753880
DOI: 10.1016/J.EJMECH.2023.115177
Page generated: Mon Aug 12 18:57:20 2024
ISSN: ISSN 0223-5234
PubMed: 36753880
DOI: 10.1016/J.EJMECH.2023.115177
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