Potassium »
PDB 7c1o-7fs0 »
7frv »
Potassium in PDB 7frv: Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 3
Enzymatic activity of Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 3
All present enzymatic activity of Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 3:
2.7.1.40;
2.7.1.40;
Protein crystallography data
The structure of Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 3, PDB code: 7frv
was solved by
A.Lulla,
O.Nilsson,
P.Brear,
A.Nain-Perez,
M.Grotli,
M.Hyvonen,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 188.34 / 2.00 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 208.043, 112.707, 188.415, 90, 91.59, 90 |
| R / Rfree (%) | 20.6 / 23.2 |
Other elements in 7frv:
The structure of Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 3 also contains other interesting chemical elements:
| Magnesium | (Mg) | 8 atoms |
Potassium Binding Sites:
The binding sites of Potassium atom in the Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 3
(pdb code 7frv). This binding sites where shown within
5.0 Angstroms radius around Potassium atom.
In total 8 binding sites of Potassium where determined in the Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 3, PDB code: 7frv:
Jump to Potassium binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
In total 8 binding sites of Potassium where determined in the Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 3, PDB code: 7frv:
Jump to Potassium binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
Potassium binding site 1 out of 8 in 7frv
Go back to
Potassium Binding Sites List in 7frv
Potassium binding site 1 out
of 8 in the Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 3
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 1 of Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 3 within 5.0Å range:
|
Potassium binding site 2 out of 8 in 7frv
Go back to
Potassium Binding Sites List in 7frv
Potassium binding site 2 out
of 8 in the Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 3
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 2 of Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 3 within 5.0Å range:
|
Potassium binding site 3 out of 8 in 7frv
Go back to
Potassium Binding Sites List in 7frv
Potassium binding site 3 out
of 8 in the Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 3
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 3 of Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 3 within 5.0Å range:
|
Potassium binding site 4 out of 8 in 7frv
Go back to
Potassium Binding Sites List in 7frv
Potassium binding site 4 out
of 8 in the Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 3
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 4 of Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 3 within 5.0Å range:
|
Potassium binding site 5 out of 8 in 7frv
Go back to
Potassium Binding Sites List in 7frv
Potassium binding site 5 out
of 8 in the Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 3
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 5 of Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 3 within 5.0Å range:
|
Potassium binding site 6 out of 8 in 7frv
Go back to
Potassium Binding Sites List in 7frv
Potassium binding site 6 out
of 8 in the Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 3
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 6 of Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 3 within 5.0Å range:
|
Potassium binding site 7 out of 8 in 7frv
Go back to
Potassium Binding Sites List in 7frv
Potassium binding site 7 out
of 8 in the Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 3
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 7 of Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 3 within 5.0Å range:
|
Potassium binding site 8 out of 8 in 7frv
Go back to
Potassium Binding Sites List in 7frv
Potassium binding site 8 out
of 8 in the Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 3
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 8 of Structure of Liver Pyruvate Kinase in Complex with Allosteric Modulator 3 within 5.0Å range:
|
Reference:
A.Nain-Perez,
O.Nilsson,
A.Lulla,
L.Haversen,
P.Brear,
S.Liljenberg,
M.Hyvonen,
J.Boren,
M.Grotli.
Tuning Liver Pyruvate Kinase Activity Up or Down with A New Class of Allosteric Modulators. Eur.J.Med.Chem. V. 250 15177 2023.
ISSN: ISSN 0223-5234
PubMed: 36753880
DOI: 10.1016/J.EJMECH.2023.115177
Page generated: Mon Aug 12 18:55:50 2024
ISSN: ISSN 0223-5234
PubMed: 36753880
DOI: 10.1016/J.EJMECH.2023.115177
Last articles
Zn in 9JPJZn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
