Potassium in PDB 7byn: Cryo-Em Structure of Human KCNQ4 with Linopirdine

The binding sites of Potassium atom in the Cryo-Em Structure of Human KCNQ4 with Linopirdine (pdb code 7byn). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 3 binding sites of Potassium where determined in the Cryo-Em Structure of Human KCNQ4 with Linopirdine, PDB code: 7byn:
Jump to Potassium binding site number: 1; 2; 3;

Potassium binding site 1 out of 3 in the Cryo-Em Structure of Human KCNQ4 with Linopirdine


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Cryo-Em Structure of Human KCNQ4 with Linopirdine within 5.0Å range: probe atom residue distance (Å) B Occ A:K702 b:30.0 occ:1.00 O E:THR283 2.6 44.0 1.0 O C:ILE284 2.8 44.9 1.0 O C:THR283 2.9 44.9 1.0 O E:ILE284 2.9 44.9 1.0 O A:ILE284 2.9 73.8 1.0 O A:THR283 3.0 56.1 1.0 O G:ILE284 3.0 44.5 1.0 O G:THR283 3.1 43.7 1.0 K A:K704 3.3 30.0 1.0 C E:ILE284 3.7 44.9 1.0 C C:ILE284 3.7 44.9 1.0 C E:THR283 3.8 44.0 1.0 C A:ILE284 3.8 73.8 1.0 C G:ILE284 3.9 44.5 1.0 C C:THR283 4.0 44.9 1.0 CA E:ILE284 4.1 44.9 1.0 C A:THR283 4.1 56.1 1.0 CA C:ILE284 4.2 44.9 1.0 C G:THR283 4.2 43.7 1.0 CA A:ILE284 4.3 73.8 1.0 CA G:ILE284 4.4 44.5 1.0 N E:ILE284 4.4 44.9 1.0 N C:ILE284 4.6 44.9 1.0 N E:GLY285 4.7 43.2 1.0 N A:ILE284 4.7 73.8 1.0 N C:GLY285 4.7 44.4 1.0 N G:ILE284 4.8 44.5 1.0 N A:GLY285 4.9 55.9 1.0 CA E:THR283 4.9 44.0 1.0 N G:GLY285 5.0 43.2 1.0

Potassium binding site 2 out of 3 in the Cryo-Em Structure of Human KCNQ4 with Linopirdine


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Cryo-Em Structure of Human KCNQ4 with Linopirdine within 5.0Å range: probe atom residue distance (Å) B Occ A:K703 b:30.0 occ:1.00 O E:GLY285 2.8 43.2 1.0 O E:TYR286 2.8 47.8 1.0 O C:TYR286 2.9 47.8 1.0 O A:TYR286 3.0 52.6 1.0 O G:TYR286 3.0 47.5 1.0 O C:GLY285 3.1 44.4 1.0 O A:GLY285 3.1 55.9 1.0 O G:GLY285 3.2 43.2 1.0 C E:TYR286 3.4 47.8 1.0 C C:TYR286 3.6 47.8 1.0 C A:TYR286 3.7 52.6 1.0 C G:TYR286 3.8 47.5 1.0 C E:GLY285 3.9 43.2 1.0 CA E:TYR286 4.0 47.8 1.0 N E:GLY287 4.1 53.1 1.0 CA C:TYR286 4.2 47.8 1.0 C C:GLY285 4.2 44.4 1.0 CA A:TYR286 4.3 52.6 1.0 C A:GLY285 4.3 55.9 1.0 N C:GLY287 4.3 55.7 1.0 C G:GLY285 4.4 43.2 1.0 CA G:TYR286 4.4 47.5 1.0 N A:GLY287 4.4 55.5 1.0 N E:TYR286 4.5 47.8 1.0 N G:GLY287 4.5 53.3 1.0 CA E:GLY287 4.6 53.1 1.0 CA C:GLY287 4.7 55.7 1.0 N C:TYR286 4.7 47.8 1.0 CA A:GLY287 4.8 55.5 1.0 N A:TYR286 4.8 52.6 1.0 N G:TYR286 4.9 47.5 1.0 CA G:GLY287 4.9 53.3 1.0

Potassium binding site 3 out of 3 in the Cryo-Em Structure of Human KCNQ4 with Linopirdine


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Cryo-Em Structure of Human KCNQ4 with Linopirdine within 5.0Å range: probe atom residue distance (Å) B Occ A:K704 b:30.0 occ:1.00 O C:THR283 3.0 44.9 1.0 O E:THR283 3.0 44.0 1.0 O A:THR283 3.2 56.1 1.0 O G:THR283 3.3 43.7 1.0 K A:K702 3.3 30.0 1.0 OG1 E:THR283 3.5 44.0 1.0 CB E:THR283 3.5 44.0 1.0 OG1 C:THR283 3.7 44.9 1.0 CB C:THR283 3.7 44.9 1.0 OG1 A:THR283 3.8 56.1 1.0 OG1 G:THR283 3.9 43.7 1.0 CB A:THR283 3.9 56.1 1.0 C E:THR283 4.0 44.0 1.0 C C:THR283 4.0 44.9 1.0 CB G:THR283 4.0 43.7 1.0 C A:THR283 4.2 56.1 1.0 C G:THR283 4.3 43.7 1.0 CA E:THR283 4.4 44.0 1.0 CA C:THR283 4.5 44.9 1.0 CG2 E:THR283 4.6 44.0 1.0 CA A:THR283 4.7 56.1 1.0 CA G:THR283 4.8 43.7 1.0 CG2 C:THR283 4.9 44.9 1.0

T.Li, K.Wu, Z.Yue, Y.Wang, F.Zhang, H.Shen. Structural Basis For the Modulation of Human KCNQ4 By Small-Molecule Drugs. Mol.Cell 2020.
ISSN: ISSN 1097-2765
PubMed: 33238160
DOI: 10.1016/J.MOLCEL.2020.10.037