Potassium in PDB 7al9: Human Gtp Cyclohydrolase I Feedback Regulatory Protein (Gfrp) in Complex with Phenylalanine

Protein crystallography data

The structure of Human Gtp Cyclohydrolase I Feedback Regulatory Protein (Gfrp) in Complex with Phenylalanine, PDB code: 7al9 was solved by R.Ebenhoch, H.Nar, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 54.68 / 1.75
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 66.939, 98.123, 67.455, 90, 102.53, 90
R / Rfree (%) 20.3 / 23.5

Potassium Binding Sites:

The binding sites of Potassium atom in the Human Gtp Cyclohydrolase I Feedback Regulatory Protein (Gfrp) in Complex with Phenylalanine (pdb code 7al9). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 10 binding sites of Potassium where determined in the Human Gtp Cyclohydrolase I Feedback Regulatory Protein (Gfrp) in Complex with Phenylalanine, PDB code: 7al9:
Jump to Potassium binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Potassium binding site 1 out of 10 in 7al9

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Potassium binding site 1 out of 10 in the Human Gtp Cyclohydrolase I Feedback Regulatory Protein (Gfrp) in Complex with Phenylalanine


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Human Gtp Cyclohydrolase I Feedback Regulatory Protein (Gfrp) in Complex with Phenylalanine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K101

b:38.1
occ:1.00
 O A:ARG10 2.4 17.8 1.0
O A:HOH208 2.4 25.7 1.0
O A:VAL13 2.4 23.5 1.0
OG1 A:THR7 2.5 16.7 1.0
O A:GLN8 2.6 16.4 1.0
O A:HOH217 3.1 17.9 1.0
C A:ARG10 3.5 17.3 1.0
C A:VAL13 3.6 23.6 1.0
CB A:THR7 3.6 15.4 1.0
N A:GLN8 3.6 14.7 1.0
CG2 A:THR7 3.7 14.8 1.0
C A:GLN8 3.7 16.2 1.0
N A:ARG10 3.9 16.8 1.0
O A:GLY14 4.0 23.0 1.0
CA A:ARG10 4.2 17.6 1.0
C A:GLY14 4.2 22.9 1.0
CA A:GLN8 4.2 16.5 1.0
C A:THR7 4.3 15.5 1.0
O A:PRO15 4.3 19.7 1.0
CA A:THR7 4.4 15.3 1.0
CA A:GLY14 4.4 23.5 1.0
N A:GLY14 4.4 23.8 1.0
O B:HOH230 4.5 53.8 1.0
CA A:VAL13 4.5 23.8 1.0
N A:VAL13 4.5 23.4 1.0
CB A:ARG10 4.6 18.3 1.0
N A:MET11 4.6 17.7 1.0
CB A:VAL13 4.8 25.9 1.0
N A:ILE9 4.8 15.7 1.0
O B:HOH233 4.9 42.4 1.0
N A:PRO15 4.9 21.7 1.0
CA A:MET11 4.9 18.6 1.0
C A:ILE9 5.0 16.4 1.0

Potassium binding site 2 out of 10 in 7al9

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Potassium binding site 2 out of 10 in the Human Gtp Cyclohydrolase I Feedback Regulatory Protein (Gfrp) in Complex with Phenylalanine


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Human Gtp Cyclohydrolase I Feedback Regulatory Protein (Gfrp) in Complex with Phenylalanine within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K101

b:37.5
occ:1.00
 O B:ARG10 2.3 19.4 1.0
O B:VAL13 2.4 24.5 1.0
OG1 B:THR7 2.6 16.7 1.0
O B:HOH222 2.6 29.6 1.0
O B:GLN8 2.6 15.3 1.0
O B:HOH204 2.8 25.4 1.0
C B:ARG10 3.5 19.1 1.0
C B:VAL13 3.6 25.2 1.0
CB B:THR7 3.6 16.7 1.0
N B:GLN8 3.7 15.7 1.0
C B:GLN8 3.7 16.1 1.0
CG2 B:THR7 3.7 15.4 1.0
N B:ARG10 3.8 17.8 1.0
O B:GLY14 4.0 23.9 1.0
CA B:ARG10 4.1 19.1 1.0
C B:GLY14 4.2 23.8 1.0
CA B:GLN8 4.3 16.8 1.0
C B:THR7 4.3 16.5 1.0
O B:PRO15 4.3 21.5 1.0
CA B:GLY14 4.4 24.0 1.0
N B:GLY14 4.4 24.2 1.0
CA B:THR7 4.4 16.5 1.0
N B:VAL13 4.5 27.1 1.0
CA B:VAL13 4.5 27.0 1.0
CB B:ARG10 4.5 21.6 1.0
O B:HOH232 4.5 41.5 1.0
N B:MET11 4.6 19.6 1.0
CB B:VAL13 4.7 29.0 1.0
N B:ILE9 4.8 16.3 1.0
CA B:MET11 4.8 21.8 1.0
N B:PRO15 4.9 23.9 1.0
C B:ILE9 5.0 18.0 1.0

Potassium binding site 3 out of 10 in 7al9

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Potassium binding site 3 out of 10 in the Human Gtp Cyclohydrolase I Feedback Regulatory Protein (Gfrp) in Complex with Phenylalanine


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Human Gtp Cyclohydrolase I Feedback Regulatory Protein (Gfrp) in Complex with Phenylalanine within 5.0Å range:
probe atom residue distance (Å) B Occ
C:K101

b:43.4
occ:1.00
 O C:VAL13 2.4 22.2 1.0
O C:HOH232 2.4 31.2 1.0
O C:ARG10 2.5 22.9 1.0
OG1 C:THR7 2.6 21.1 1.0
O C:GLN8 2.7 19.0 1.0
C C:VAL13 3.5 23.8 1.0
C C:ARG10 3.7 22.8 1.0
CB C:THR7 3.7 19.4 1.0
N C:GLN8 3.8 19.7 1.0
C C:GLN8 3.8 20.3 1.0
O C:GLY14 3.8 26.4 1.0
CG2 C:THR7 3.8 18.4 1.0
N C:ARG10 3.9 21.3 1.0
C C:GLY14 4.0 25.4 1.0
CG1 C:VAL13 4.1 26.1 1.0
O C:PRO15 4.2 23.7 1.0
CA C:GLY14 4.2 24.7 1.0
CA C:ARG10 4.3 22.5 1.0
N C:GLY14 4.3 24.1 1.0
CA C:GLN8 4.4 20.9 1.0
C C:THR7 4.4 19.3 1.0
CA C:THR7 4.5 19.1 1.0
CA C:VAL13 4.5 24.7 1.0
N C:VAL13 4.5 24.9 1.0
CB C:ARG10 4.6 25.0 1.0
N C:PRO15 4.7 25.4 1.0
N C:MET11 4.7 23.1 1.0
CB C:VAL13 4.9 26.0 1.0
N C:ILE9 4.9 20.4 1.0

Potassium binding site 4 out of 10 in 7al9

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Potassium binding site 4 out of 10 in the Human Gtp Cyclohydrolase I Feedback Regulatory Protein (Gfrp) in Complex with Phenylalanine


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Human Gtp Cyclohydrolase I Feedback Regulatory Protein (Gfrp) in Complex with Phenylalanine within 5.0Å range:
probe atom residue distance (Å) B Occ
D:K101

b:55.0
occ:1.00
 O D:VAL13 2.6 23.5 1.0
O D:GLN8 2.6 17.6 1.0
O D:ARG10 2.7 23.4 1.0
O D:HOH210 2.9 22.7 1.0
OG1 D:THR7 2.9 20.9 1.0
O D:GLY14 3.6 24.9 1.0
C D:VAL13 3.6 25.2 1.0
C D:GLN8 3.8 19.1 1.0
C D:ARG10 3.8 23.3 1.0
N D:GLN8 3.9 18.5 1.0
C D:GLY14 3.9 24.0 1.0
N D:ARG10 3.9 21.6 1.0
CB D:THR7 4.1 18.7 1.0
O D:PRO15 4.2 21.3 1.0
CA D:GLY14 4.2 24.1 1.0
CA D:ARG10 4.3 23.6 1.0
CG1 D:VAL13 4.3 29.2 1.0
O D:HOH230 4.3 44.9 1.0
CG2 D:THR7 4.3 16.8 1.0
N D:GLY14 4.4 24.1 1.0
CA D:GLN8 4.4 19.9 1.0
CB D:ARG10 4.4 25.7 1.0
N D:PRO15 4.5 23.3 1.0
C D:THR7 4.6 18.2 1.0
CA D:VAL13 4.7 27.1 1.0
CA D:THR7 4.7 17.5 1.0
N D:VAL13 4.8 27.2 1.0
N D:ILE9 4.9 18.4 1.0
CD D:PRO15 4.9 23.3 1.0
N D:MET11 4.9 23.8 1.0

Potassium binding site 5 out of 10 in 7al9

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Potassium binding site 5 out of 10 in the Human Gtp Cyclohydrolase I Feedback Regulatory Protein (Gfrp) in Complex with Phenylalanine


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 5 of Human Gtp Cyclohydrolase I Feedback Regulatory Protein (Gfrp) in Complex with Phenylalanine within 5.0Å range:
probe atom residue distance (Å) B Occ
E:K101

b:38.2
occ:1.00
 O E:VAL13 2.2 20.5 1.0
O E:ARG10 2.4 22.2 1.0
O E:HOH220 2.4 24.6 1.0
OG1 E:THR7 2.4 19.4 1.0
O E:GLN8 2.7 17.5 1.0
O E:HOH215 3.3 30.7 1.0
C E:VAL13 3.4 21.4 1.0
C E:ARG10 3.5 22.0 1.0
CB E:THR7 3.5 19.2 1.0
CG2 E:THR7 3.6 19.5 1.0
N E:GLN8 3.7 17.3 1.0
C E:GLN8 3.8 17.6 1.0
N E:ARG10 4.0 20.9 1.0
O E:GLY14 4.0 22.9 1.0
C E:GLY14 4.2 22.5 1.0
N E:GLY14 4.3 21.4 1.0
CA E:ARG10 4.3 22.2 1.0
CA E:GLY14 4.3 21.6 1.0
O E:PRO15 4.3 21.4 1.0
C E:THR7 4.3 18.0 1.0
CA E:THR7 4.4 18.7 1.0
CA E:VAL13 4.4 22.6 1.0
CA E:GLN8 4.4 17.5 1.0
N E:VAL13 4.4 22.8 1.0
CG2 E:VAL13 4.4 26.4 1.0
N E:MET11 4.6 21.4 1.0
CB E:ARG10 4.6 24.6 1.0
CA E:MET11 4.8 21.3 1.0
CB E:VAL13 4.9 24.9 1.0
O E:HOH236 4.9 41.0 1.0
N E:PRO15 4.9 22.6 1.0
N E:ILE9 4.9 17.6 1.0
C E:MET11 5.0 21.7 1.0

Potassium binding site 6 out of 10 in 7al9

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Potassium binding site 6 out of 10 in the Human Gtp Cyclohydrolase I Feedback Regulatory Protein (Gfrp) in Complex with Phenylalanine


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 6 of Human Gtp Cyclohydrolase I Feedback Regulatory Protein (Gfrp) in Complex with Phenylalanine within 5.0Å range:
probe atom residue distance (Å) B Occ
F:K101

b:41.2
occ:1.00
 O F:HOH213 2.3 26.9 1.0
O F:ARG10 2.3 25.6 1.0
O F:VAL13 2.5 28.0 1.0
OG1 F:THR7 2.5 20.8 1.0
O F:GLN8 2.5 20.8 1.0
O F:HOH215 3.2 31.0 1.0
C F:ARG10 3.5 24.6 1.0
CB F:THR7 3.6 19.7 1.0
C F:VAL13 3.6 28.1 1.0
C F:GLN8 3.6 20.3 1.0
N F:GLN8 3.6 18.3 1.0
CG2 F:THR7 3.7 19.8 1.0
N F:ARG10 3.8 22.1 1.0
O F:GLY14 4.0 25.6 1.0
CA F:ARG10 4.1 23.5 1.0
CA F:GLN8 4.2 19.4 1.0
C F:THR7 4.3 18.4 1.0
CG1 F:VAL13 4.3 29.4 1.0
C F:GLY14 4.3 26.1 1.0
O F:PRO15 4.4 23.7 1.0
CA F:THR7 4.4 18.4 1.0
CA F:GLY14 4.4 26.7 1.0
N F:GLY14 4.4 27.4 1.0
N F:VAL13 4.5 27.6 1.0
N F:MET11 4.5 24.5 1.0
CB F:ARG10 4.5 25.2 1.0
CA F:VAL13 4.6 28.4 1.0
O F:HOH230 4.6 42.1 1.0
O F:HOH231 4.6 42.4 1.0
N F:ILE9 4.7 20.6 1.0
CA F:MET11 4.8 25.0 1.0
C F:ILE9 4.9 21.7 1.0
N F:PRO15 5.0 25.4 1.0

Potassium binding site 7 out of 10 in 7al9

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Potassium binding site 7 out of 10 in the Human Gtp Cyclohydrolase I Feedback Regulatory Protein (Gfrp) in Complex with Phenylalanine


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 7 of Human Gtp Cyclohydrolase I Feedback Regulatory Protein (Gfrp) in Complex with Phenylalanine within 5.0Å range:
probe atom residue distance (Å) B Occ
G:K101

b:39.5
occ:1.00
 O G:HOH225 2.3 30.6 1.0
O G:ARG10 2.4 20.8 1.0
O G:VAL13 2.4 22.1 1.0
OG1 G:THR7 2.5 18.9 1.0
O G:GLN8 2.6 16.8 1.0
O G:HOH217 2.9 19.4 1.0
C G:ARG10 3.5 21.1 1.0
C G:VAL13 3.5 23.6 1.0
CB G:THR7 3.6 17.7 1.0
N G:GLN8 3.7 16.1 1.0
CG2 G:THR7 3.7 16.7 1.0
C G:GLN8 3.7 16.8 1.0
N G:ARG10 3.8 20.4 1.0
O G:GLY14 4.0 23.3 1.0
CA G:ARG10 4.2 21.6 1.0
C G:GLY14 4.2 22.6 1.0
O G:PRO15 4.3 20.1 1.0
C G:THR7 4.3 15.7 1.0
CA G:GLN8 4.3 16.9 1.0
CA G:GLY14 4.3 22.8 1.0
N G:GLY14 4.4 23.1 1.0
CA G:THR7 4.4 16.9 1.0
CG2 G:VAL13 4.5 28.0 1.0
CB G:ARG10 4.5 24.3 1.0
CA G:VAL13 4.5 24.8 1.0
O G:HOH236 4.5 34.0 1.0
N G:VAL13 4.5 24.1 1.0
N G:MET11 4.6 21.0 1.0
CA G:MET11 4.8 21.1 1.0
N G:ILE9 4.8 16.9 1.0
N G:PRO15 4.9 21.8 1.0
C G:ILE9 5.0 19.1 1.0
CB G:VAL13 5.0 27.4 1.0

Potassium binding site 8 out of 10 in 7al9

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Potassium binding site 8 out of 10 in the Human Gtp Cyclohydrolase I Feedback Regulatory Protein (Gfrp) in Complex with Phenylalanine


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 8 of Human Gtp Cyclohydrolase I Feedback Regulatory Protein (Gfrp) in Complex with Phenylalanine within 5.0Å range:
probe atom residue distance (Å) B Occ
H:K101

b:46.0
occ:1.00
 O H:VAL13 2.4 26.9 1.0
O H:HOH221 2.5 35.7 1.0
OG1 H:THR7 2.6 21.8 1.0
O H:HOH214 2.7 27.4 1.0
O H:GLN8 2.7 16.2 1.0
O H:ARG10 2.7 23.4 1.0
C H:VAL13 3.5 28.0 1.0
O H:GLY14 3.7 28.6 1.0
N H:GLN8 3.7 17.6 1.0
C H:GLN8 3.8 16.9 1.0
CB H:THR7 3.8 20.6 1.0
C H:ARG10 3.8 22.3 1.0
C H:GLY14 3.9 27.7 1.0
CG2 H:THR7 4.0 20.4 1.0
N H:ARG10 4.1 21.0 1.0
O H:PRO15 4.1 26.1 1.0
CA H:GLY14 4.1 27.8 1.0
O H:HOH226 4.2 40.7 1.0
N H:GLY14 4.2 27.6 1.0
CA H:GLN8 4.4 17.6 1.0
CA H:ARG10 4.4 21.8 1.0
C H:THR7 4.4 18.5 1.0
CA H:THR7 4.5 19.1 1.0
CA H:VAL13 4.5 29.0 1.0
N H:PRO15 4.5 26.5 1.0
CB H:ARG10 4.6 23.4 1.0
N H:VAL13 4.7 28.0 1.0
CB H:VAL13 4.7 32.1 1.0
N H:MET11 4.9 23.0 1.0
N H:ILE9 4.9 16.9 1.0

Potassium binding site 9 out of 10 in 7al9

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Potassium binding site 9 out of 10 in the Human Gtp Cyclohydrolase I Feedback Regulatory Protein (Gfrp) in Complex with Phenylalanine


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 9 of Human Gtp Cyclohydrolase I Feedback Regulatory Protein (Gfrp) in Complex with Phenylalanine within 5.0Å range:
probe atom residue distance (Å) B Occ
I:K101

b:44.5
occ:1.00
 O I:ARG10 2.3 21.2 1.0
O I:VAL13 2.4 24.0 1.0
O I:HOH213 2.5 27.8 1.0
OG1 I:THR7 2.5 17.2 1.0
O I:GLN8 2.6 19.0 1.0
O I:HOH214 2.9 20.3 1.0
C I:ARG10 3.5 20.6 1.0
C I:VAL13 3.6 25.0 1.0
CB I:THR7 3.6 16.9 1.0
CG2 I:THR7 3.6 16.5 1.0
N I:GLN8 3.7 15.9 1.0
C I:GLN8 3.7 17.0 1.0
N I:ARG10 3.8 19.4 1.0
O I:GLY14 4.1 26.7 1.0
CA I:ARG10 4.2 20.2 1.0
C I:GLY14 4.3 26.2 1.0
C I:THR7 4.3 15.9 1.0
CA I:GLN8 4.3 16.2 1.0
O I:PRO15 4.3 23.4 1.0
CA I:THR7 4.4 16.2 1.0
CA I:GLY14 4.4 25.1 1.0
N I:GLY14 4.4 24.8 1.0
N I:VAL13 4.5 26.1 1.0
CA I:VAL13 4.5 25.9 1.0
CB I:ARG10 4.5 22.0 1.0
N I:MET11 4.6 20.6 1.0
O C:HOH239 4.6 44.0 1.0
CB I:VAL13 4.7 27.1 1.0
CA I:MET11 4.8 21.5 1.0
N I:ILE9 4.8 16.4 1.0
N I:PRO15 5.0 26.0 1.0
C I:ILE9 5.0 18.9 1.0

Potassium binding site 10 out of 10 in 7al9

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Potassium binding site 10 out of 10 in the Human Gtp Cyclohydrolase I Feedback Regulatory Protein (Gfrp) in Complex with Phenylalanine


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 10 of Human Gtp Cyclohydrolase I Feedback Regulatory Protein (Gfrp) in Complex with Phenylalanine within 5.0Å range:
probe atom residue distance (Å) B Occ
J:K101

b:39.3
occ:1.00
 O J:ARG10 2.4 17.6 1.0
O J:HOH212 2.4 32.6 1.0
OG1 J:THR7 2.4 18.3 1.0
O J:VAL13 2.5 24.9 1.0
O J:GLN8 2.5 16.0 1.0
O J:HOH205 3.2 27.7 1.0
CB J:THR7 3.5 17.6 1.0
C J:ARG10 3.5 18.8 1.0
N J:GLN8 3.5 15.6 1.0
CG2 J:THR7 3.6 18.4 1.0
C J:GLN8 3.6 16.0 1.0
C J:VAL13 3.6 25.3 1.0
N J:ARG10 3.9 19.0 1.0
O J:GLY14 4.0 23.1 1.0
CA J:GLN8 4.2 15.6 1.0
C J:THR7 4.2 15.9 1.0
CA J:ARG10 4.2 20.0 1.0
C J:GLY14 4.2 23.1 1.0
O J:PRO15 4.3 20.8 1.0
CA J:THR7 4.3 16.4 1.0
CA J:GLY14 4.4 23.7 1.0
N J:GLY14 4.5 24.4 1.0
CG2 J:VAL13 4.5 29.8 1.0
CA J:VAL13 4.6 26.6 1.0
N J:VAL13 4.6 25.8 1.0
N J:MET11 4.6 18.9 1.0
CB J:ARG10 4.6 24.1 1.0
O D:HOH226 4.7 46.4 1.0
N J:ILE9 4.8 16.6 1.0
CA J:MET11 4.8 19.7 1.0
N J:PRO15 4.9 22.2 1.0
CB J:VAL13 5.0 29.1 1.0

Reference:

R.Ebenhoch, M.Bauer, D.Reinert, A.Kersting, S.Huber, A.Schmid, I.Hinz, M.Feiler, K.Mueller, H.Nar. Using Hybrid Approaches to Study the Allosteric Regulation of Gtp Cyclohydrolase I To Be Published.
Page generated: Fri Nov 5 14:25:13 2021

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