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Potassium in PDB 6ws1: Crystal Structure of Human Phenylethanolamine N-Methyltransferase (Pnmt) in Complex with (2S)-2-Amino-4-((((2R,5R)-5-(6-Amino-9H-Purin- 9-Yl)-3,4-Dihydroxytetrahydrofuran-2-Yl)Methyl)(3-(7,8-Dichloro-1,2, 3,4-Tetrahydroisoquinolin-4-Yl)Propyl)Amino)Butanoic Acid and Adohcy (Sah)Enzymatic activity of Crystal Structure of Human Phenylethanolamine N-Methyltransferase (Pnmt) in Complex with (2S)-2-Amino-4-((((2R,5R)-5-(6-Amino-9H-Purin- 9-Yl)-3,4-Dihydroxytetrahydrofuran-2-Yl)Methyl)(3-(7,8-Dichloro-1,2, 3,4-Tetrahydroisoquinolin-4-Yl)Propyl)Amino)Butanoic Acid and Adohcy (Sah)
All present enzymatic activity of Crystal Structure of Human Phenylethanolamine N-Methyltransferase (Pnmt) in Complex with (2S)-2-Amino-4-((((2R,5R)-5-(6-Amino-9H-Purin- 9-Yl)-3,4-Dihydroxytetrahydrofuran-2-Yl)Methyl)(3-(7,8-Dichloro-1,2, 3,4-Tetrahydroisoquinolin-4-Yl)Propyl)Amino)Butanoic Acid and Adohcy (Sah):
2.1.1.28; Protein crystallography data
The structure of Crystal Structure of Human Phenylethanolamine N-Methyltransferase (Pnmt) in Complex with (2S)-2-Amino-4-((((2R,5R)-5-(6-Amino-9H-Purin- 9-Yl)-3,4-Dihydroxytetrahydrofuran-2-Yl)Methyl)(3-(7,8-Dichloro-1,2, 3,4-Tetrahydroisoquinolin-4-Yl)Propyl)Amino)Butanoic Acid and Adohcy (Sah), PDB code: 6ws1
was solved by
R.K.Harijan,
N.Mahmoodi,
J.B.Bonanno,
S.C.Almo,
V.L.Schramm,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6ws1:
The structure of Crystal Structure of Human Phenylethanolamine N-Methyltransferase (Pnmt) in Complex with (2S)-2-Amino-4-((((2R,5R)-5-(6-Amino-9H-Purin- 9-Yl)-3,4-Dihydroxytetrahydrofuran-2-Yl)Methyl)(3-(7,8-Dichloro-1,2, 3,4-Tetrahydroisoquinolin-4-Yl)Propyl)Amino)Butanoic Acid and Adohcy (Sah) also contains other interesting chemical elements:
Potassium Binding Sites:
The binding sites of Potassium atom in the Crystal Structure of Human Phenylethanolamine N-Methyltransferase (Pnmt) in Complex with (2S)-2-Amino-4-((((2R,5R)-5-(6-Amino-9H-Purin- 9-Yl)-3,4-Dihydroxytetrahydrofuran-2-Yl)Methyl)(3-(7,8-Dichloro-1,2, 3,4-Tetrahydroisoquinolin-4-Yl)Propyl)Amino)Butanoic Acid and Adohcy (Sah)
(pdb code 6ws1). This binding sites where shown within
5.0 Angstroms radius around Potassium atom.
In total only one binding site of Potassium was determined in the Crystal Structure of Human Phenylethanolamine N-Methyltransferase (Pnmt) in Complex with (2S)-2-Amino-4-((((2R,5R)-5-(6-Amino-9H-Purin- 9-Yl)-3,4-Dihydroxytetrahydrofuran-2-Yl)Methyl)(3-(7,8-Dichloro-1,2, 3,4-Tetrahydroisoquinolin-4-Yl)Propyl)Amino)Butanoic Acid and Adohcy (Sah), PDB code: 6ws1: Potassium binding site 1 out of 1 in 6ws1Go back to Potassium Binding Sites List in 6ws1
Potassium binding site 1 out
of 1 in the Crystal Structure of Human Phenylethanolamine N-Methyltransferase (Pnmt) in Complex with (2S)-2-Amino-4-((((2R,5R)-5-(6-Amino-9H-Purin- 9-Yl)-3,4-Dihydroxytetrahydrofuran-2-Yl)Methyl)(3-(7,8-Dichloro-1,2, 3,4-Tetrahydroisoquinolin-4-Yl)Propyl)Amino)Butanoic Acid and Adohcy (Sah)
Mono view Stereo pair view
Reference:
N.Mahmoodi,
R.K.Harijan,
V.L.Schramm.
Transition-State Analogues of Phenylethanolaminen-Methyltransferase. J.Am.Chem.Soc. V. 142 14222 2020.
Page generated: Mon Dec 14 02:23:07 2020
ISSN: ESSN 1520-5126 PubMed: 32702980 DOI: 10.1021/JACS.0C05446 |
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