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Potassium in PDB 6wdw: Crystal Structure of Danio Rerio Histone Deacetylase 10 in Complex with Dimethylaminoethylindole Phenylhydroxamate Inhibitor
Enzymatic activity of Crystal Structure of Danio Rerio Histone Deacetylase 10 in Complex with Dimethylaminoethylindole Phenylhydroxamate Inhibitor
All present enzymatic activity of Crystal Structure of Danio Rerio Histone Deacetylase 10 in Complex with Dimethylaminoethylindole Phenylhydroxamate Inhibitor:
3.5.1.48; 3.5.1.62;
3.5.1.48; 3.5.1.62;
Protein crystallography data
The structure of Crystal Structure of Danio Rerio Histone Deacetylase 10 in Complex with Dimethylaminoethylindole Phenylhydroxamate Inhibitor, PDB code: 6wdw
was solved by
C.J.Herbst-Gervasoni,
D.W.Christianson,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 67.14 / 2.20 |
| Space group | P 31 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 80.563, 80.563, 246.907, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 20 / 23.6 |
Other elements in 6wdw:
The structure of Crystal Structure of Danio Rerio Histone Deacetylase 10 in Complex with Dimethylaminoethylindole Phenylhydroxamate Inhibitor also contains other interesting chemical elements:
| Zinc | (Zn) | 1 atom |
Potassium Binding Sites:
The binding sites of Potassium atom in the Crystal Structure of Danio Rerio Histone Deacetylase 10 in Complex with Dimethylaminoethylindole Phenylhydroxamate Inhibitor
(pdb code 6wdw). This binding sites where shown within
5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Crystal Structure of Danio Rerio Histone Deacetylase 10 in Complex with Dimethylaminoethylindole Phenylhydroxamate Inhibitor, PDB code: 6wdw:
Jump to Potassium binding site number: 1; 2;
In total 2 binding sites of Potassium where determined in the Crystal Structure of Danio Rerio Histone Deacetylase 10 in Complex with Dimethylaminoethylindole Phenylhydroxamate Inhibitor, PDB code: 6wdw:
Jump to Potassium binding site number: 1; 2;
Potassium binding site 1 out of 2 in 6wdw
Go back to
Potassium Binding Sites List in 6wdw
Potassium binding site 1 out
of 2 in the Crystal Structure of Danio Rerio Histone Deacetylase 10 in Complex with Dimethylaminoethylindole Phenylhydroxamate Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 1 of Crystal Structure of Danio Rerio Histone Deacetylase 10 in Complex with Dimethylaminoethylindole Phenylhydroxamate Inhibitor within 5.0Å range:
|
Potassium binding site 2 out of 2 in 6wdw
Go back to
Potassium Binding Sites List in 6wdw
Potassium binding site 2 out
of 2 in the Crystal Structure of Danio Rerio Histone Deacetylase 10 in Complex with Dimethylaminoethylindole Phenylhydroxamate Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 2 of Crystal Structure of Danio Rerio Histone Deacetylase 10 in Complex with Dimethylaminoethylindole Phenylhydroxamate Inhibitor within 5.0Å range:
|
Reference:
C.J.Herbst-Gervasoni,
R.R.Steimbach,
M.Morgen,
A.K.Miller,
D.W.Christianson.
Structural Basis For the Selective Inhibition of HDAC10, the Cytosolic Polyamine Deacetylase. Acs Chem.Biol. V. 15 2154 2020.
ISSN: ESSN 1554-8937
PubMed: 32659072
DOI: 10.1021/ACSCHEMBIO.0C00362
Page generated: Mon Aug 12 18:14:07 2024
ISSN: ESSN 1554-8937
PubMed: 32659072
DOI: 10.1021/ACSCHEMBIO.0C00362
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