Potassium in PDB 6wca: Human Closed State TMEM175 in Kcl
Potassium Binding Sites:
The binding sites of Potassium atom in the Human Closed State TMEM175 in Kcl
(pdb code 6wca). This binding sites where shown within
5.0 Angstroms radius around Potassium atom.
In total 5 binding sites of Potassium where determined in the
Human Closed State TMEM175 in Kcl, PDB code: 6wca:
Jump to Potassium binding site number:
1;
2;
3;
4;
5;
Potassium binding site 1 out
of 5 in 6wca
Go back to
Potassium Binding Sites List in 6wca
Potassium binding site 1 out
of 5 in the Human Closed State TMEM175 in Kcl
Mono view
Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 1 of Human Closed State TMEM175 in Kcl within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:K701
b:82.3
occ:1.00
|
HB2
|
A:ALA263
|
3.3
|
34.6
|
1.0
|
HB3
|
A:SER38
|
3.5
|
37.6
|
1.0
|
O
|
A:HOH813
|
3.5
|
43.6
|
1.0
|
HG
|
A:SER38
|
3.6
|
37.6
|
1.0
|
OG
|
A:SER38
|
3.6
|
37.6
|
1.0
|
O
|
A:HOH806
|
3.8
|
40.9
|
1.0
|
K
|
B:K701
|
3.9
|
84.6
|
1.0
|
CB
|
A:SER38
|
4.0
|
37.6
|
1.0
|
CB
|
A:ALA263
|
4.2
|
34.6
|
1.0
|
HB1
|
A:ALA263
|
4.2
|
34.6
|
1.0
|
HA
|
A:SER38
|
4.3
|
37.6
|
1.0
|
O
|
A:HOH804
|
4.4
|
40.6
|
1.0
|
HG
|
B:SER38
|
4.6
|
37.5
|
1.0
|
HE21
|
A:GLN34
|
4.7
|
44.7
|
1.0
|
HB3
|
A:GLU259
|
4.7
|
43.2
|
1.0
|
CA
|
A:SER38
|
4.7
|
37.6
|
1.0
|
HB3
|
A:ALA263
|
4.8
|
34.6
|
1.0
|
HB2
|
A:SER38
|
4.8
|
37.6
|
1.0
|
HB3
|
B:SER38
|
4.8
|
37.5
|
1.0
|
HA
|
A:ALA263
|
4.9
|
34.6
|
1.0
|
O
|
A:GLU259
|
5.0
|
43.2
|
1.0
|
|
Potassium binding site 2 out
of 5 in 6wca
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Potassium Binding Sites List in 6wca
Potassium binding site 2 out
of 5 in the Human Closed State TMEM175 in Kcl
Mono view
Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 2 of Human Closed State TMEM175 in Kcl within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:K702
b:68.9
occ:1.00
|
HA2
|
A:GLY267
|
2.9
|
33.8
|
1.0
|
K
|
B:K702
|
2.9
|
67.7
|
1.0
|
HA
|
A:ALA42
|
3.1
|
37.4
|
1.0
|
HA3
|
A:GLY267
|
3.2
|
33.8
|
1.0
|
HB2
|
A:ALA42
|
3.2
|
37.4
|
1.0
|
HB1
|
A:ALA42
|
3.4
|
37.4
|
1.0
|
HB1
|
B:ALA42
|
3.4
|
37.1
|
1.0
|
CA
|
A:GLY267
|
3.4
|
33.8
|
1.0
|
HB2
|
B:ALA42
|
3.5
|
37.1
|
1.0
|
CB
|
A:ALA42
|
3.6
|
37.4
|
1.0
|
CA
|
A:ALA42
|
3.8
|
37.4
|
1.0
|
CB
|
B:ALA42
|
3.9
|
37.1
|
1.0
|
N
|
A:GLY267
|
3.9
|
33.8
|
1.0
|
H
|
A:GLY267
|
3.9
|
33.8
|
1.0
|
O
|
A:HOH804
|
4.1
|
40.6
|
1.0
|
O
|
A:HOH810
|
4.3
|
31.9
|
1.0
|
OG
|
A:SER45
|
4.4
|
35.6
|
1.0
|
O
|
A:ALA263
|
4.4
|
34.6
|
1.0
|
HB3
|
B:ALA42
|
4.4
|
37.1
|
1.0
|
HG
|
A:SER45
|
4.5
|
35.6
|
1.0
|
HB3
|
A:ALA42
|
4.6
|
37.4
|
1.0
|
C
|
A:ASP266
|
4.7
|
35.5
|
1.0
|
N
|
A:ALA42
|
4.7
|
37.4
|
1.0
|
HB2
|
A:ASP266
|
4.7
|
35.5
|
1.0
|
C
|
A:GLY267
|
4.8
|
33.8
|
1.0
|
HD11
|
A:ILE46
|
4.8
|
39.0
|
1.0
|
HA
|
B:ALA42
|
4.8
|
37.1
|
1.0
|
HD11
|
B:ILE46
|
4.8
|
38.9
|
1.0
|
C
|
A:ALA42
|
4.9
|
37.4
|
1.0
|
O
|
A:ALA42
|
4.9
|
37.4
|
1.0
|
HG13
|
A:ILE46
|
4.9
|
39.0
|
1.0
|
H
|
A:ALA42
|
5.0
|
37.4
|
1.0
|
O
|
B:HOH804
|
5.0
|
41.1
|
1.0
|
|
Potassium binding site 3 out
of 5 in 6wca
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Potassium Binding Sites List in 6wca
Potassium binding site 3 out
of 5 in the Human Closed State TMEM175 in Kcl
Mono view
Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 3 of Human Closed State TMEM175 in Kcl within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:K703
b:70.7
occ:1.00
|
HD11
|
A:LEU53
|
3.4
|
57.8
|
1.0
|
HD11
|
B:LEU53
|
3.5
|
58.3
|
1.0
|
HD13
|
A:LEU278
|
3.9
|
55.1
|
1.0
|
HD13
|
B:LEU278
|
4.0
|
55.2
|
1.0
|
HD13
|
A:LEU53
|
4.2
|
57.8
|
1.0
|
HD13
|
B:LEU53
|
4.2
|
58.3
|
1.0
|
CD1
|
A:LEU53
|
4.2
|
57.8
|
1.0
|
CD1
|
B:LEU53
|
4.3
|
58.3
|
1.0
|
O
|
A:HOH812
|
4.3
|
46.9
|
1.0
|
HD21
|
A:LEU53
|
4.3
|
57.8
|
1.0
|
O
|
B:HOH812
|
4.4
|
47.2
|
1.0
|
HD11
|
A:LEU278
|
4.4
|
55.1
|
1.0
|
HD21
|
B:LEU53
|
4.4
|
58.3
|
1.0
|
HD11
|
B:LEU278
|
4.4
|
55.2
|
1.0
|
HD21
|
A:LEU275
|
4.5
|
47.6
|
1.0
|
HD23
|
A:LEU275
|
4.5
|
47.6
|
1.0
|
CD1
|
A:LEU278
|
4.5
|
55.1
|
1.0
|
HD21
|
B:LEU275
|
4.5
|
47.9
|
1.0
|
CD1
|
B:LEU278
|
4.6
|
55.2
|
1.0
|
HD23
|
B:LEU275
|
4.6
|
47.9
|
1.0
|
HD12
|
A:LEU278
|
4.6
|
55.1
|
1.0
|
HD12
|
B:LEU278
|
4.7
|
55.2
|
1.0
|
HG12
|
B:VAL50
|
4.7
|
48.2
|
1.0
|
HG12
|
A:VAL50
|
4.7
|
48.1
|
1.0
|
HD12
|
A:LEU53
|
4.8
|
57.8
|
1.0
|
HD12
|
B:LEU53
|
4.8
|
58.3
|
1.0
|
HD22
|
A:LEU53
|
4.9
|
57.8
|
1.0
|
HD22
|
B:LEU53
|
5.0
|
58.3
|
1.0
|
CD2
|
A:LEU275
|
5.0
|
47.6
|
1.0
|
CD2
|
A:LEU53
|
5.0
|
57.8
|
1.0
|
|
Potassium binding site 4 out
of 5 in 6wca
Go back to
Potassium Binding Sites List in 6wca
Potassium binding site 4 out
of 5 in the Human Closed State TMEM175 in Kcl
Mono view
Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 4 of Human Closed State TMEM175 in Kcl within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:K701
b:84.6
occ:1.00
|
HB2
|
B:ALA263
|
3.3
|
34.5
|
1.0
|
HB3
|
B:SER38
|
3.5
|
37.5
|
1.0
|
O
|
B:HOH813
|
3.5
|
43.1
|
1.0
|
HG
|
B:SER38
|
3.5
|
37.5
|
1.0
|
OG
|
B:SER38
|
3.6
|
37.5
|
1.0
|
O
|
B:HOH807
|
3.8
|
41.3
|
1.0
|
K
|
A:K701
|
3.9
|
82.3
|
1.0
|
CB
|
B:SER38
|
4.0
|
37.5
|
1.0
|
CB
|
B:ALA263
|
4.2
|
34.5
|
1.0
|
HB1
|
B:ALA263
|
4.2
|
34.5
|
1.0
|
HA
|
B:SER38
|
4.3
|
37.5
|
1.0
|
O
|
B:HOH804
|
4.4
|
41.1
|
1.0
|
HG
|
A:SER38
|
4.6
|
37.6
|
1.0
|
HE21
|
B:GLN34
|
4.7
|
44.4
|
1.0
|
HB3
|
B:GLU259
|
4.7
|
42.9
|
1.0
|
CA
|
B:SER38
|
4.7
|
37.5
|
1.0
|
HB3
|
B:ALA263
|
4.8
|
34.5
|
1.0
|
HB3
|
A:SER38
|
4.8
|
37.6
|
1.0
|
HB2
|
B:SER38
|
4.8
|
37.5
|
1.0
|
HA
|
B:ALA263
|
4.9
|
34.5
|
1.0
|
O
|
B:GLU259
|
5.0
|
42.9
|
1.0
|
|
Potassium binding site 5 out
of 5 in 6wca
Go back to
Potassium Binding Sites List in 6wca
Potassium binding site 5 out
of 5 in the Human Closed State TMEM175 in Kcl
Mono view
Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 5 of Human Closed State TMEM175 in Kcl within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:K702
b:67.7
occ:1.00
|
HA2
|
B:GLY267
|
2.9
|
33.9
|
1.0
|
K
|
A:K702
|
2.9
|
68.9
|
1.0
|
HA
|
B:ALA42
|
3.1
|
37.1
|
1.0
|
HA3
|
B:GLY267
|
3.2
|
33.9
|
1.0
|
HB2
|
B:ALA42
|
3.2
|
37.1
|
1.0
|
HB1
|
A:ALA42
|
3.3
|
37.4
|
1.0
|
HB1
|
B:ALA42
|
3.4
|
37.1
|
1.0
|
CA
|
B:GLY267
|
3.4
|
33.9
|
1.0
|
HB2
|
A:ALA42
|
3.5
|
37.4
|
1.0
|
CB
|
B:ALA42
|
3.6
|
37.1
|
1.0
|
CA
|
B:ALA42
|
3.8
|
37.1
|
1.0
|
CB
|
A:ALA42
|
3.9
|
37.4
|
1.0
|
N
|
B:GLY267
|
3.9
|
33.9
|
1.0
|
H
|
B:GLY267
|
3.9
|
33.9
|
1.0
|
O
|
B:HOH804
|
4.1
|
41.1
|
1.0
|
O
|
B:HOH810
|
4.3
|
32.4
|
1.0
|
OG
|
B:SER45
|
4.4
|
35.6
|
1.0
|
O
|
B:ALA263
|
4.4
|
34.5
|
1.0
|
HB3
|
A:ALA42
|
4.4
|
37.4
|
1.0
|
HG
|
B:SER45
|
4.5
|
35.6
|
1.0
|
HB3
|
B:ALA42
|
4.6
|
37.1
|
1.0
|
C
|
B:ASP266
|
4.7
|
35.5
|
1.0
|
N
|
B:ALA42
|
4.7
|
37.1
|
1.0
|
HB2
|
B:ASP266
|
4.7
|
35.5
|
1.0
|
HD11
|
A:ILE46
|
4.8
|
39.0
|
1.0
|
C
|
B:GLY267
|
4.8
|
33.9
|
1.0
|
HD11
|
B:ILE46
|
4.8
|
38.9
|
1.0
|
HA
|
A:ALA42
|
4.8
|
37.4
|
1.0
|
C
|
B:ALA42
|
4.9
|
37.1
|
1.0
|
O
|
B:ALA42
|
4.9
|
37.1
|
1.0
|
HG13
|
B:ILE46
|
4.9
|
38.9
|
1.0
|
H
|
B:ALA42
|
5.0
|
37.1
|
1.0
|
O
|
A:HOH804
|
5.0
|
40.6
|
1.0
|
|
Reference:
S.Oh,
N.Paknejad,
R.K.Hite.
Gating and Selectivity Mechanisms For the Lysosomal K+Channel TMEM175. Elife V. 9 2020.
ISSN: ESSN 2050-084X
PubMed: 32228865
DOI: 10.7554/ELIFE.53430
Page generated: Mon Aug 12 18:12:50 2024
|