Potassium in PDB 6w8a: K2P2.1 (Trek-1):ML335 Complex, 10 Mm K+

Protein crystallography data

The structure of K2P2.1 (Trek-1):ML335 Complex, 10 Mm K+, PDB code: 6w8a was solved by M.Lolicato, D.L.Minor, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 15.00 / 3.00
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 66.867, 119.951, 129.245, 90, 90, 90
R / Rfree (%) 25.1 / 26.4

Other elements in 6w8a:

The structure of K2P2.1 (Trek-1):ML335 Complex, 10 Mm K+ also contains other interesting chemical elements:

Cadmium (Cd) 4 atoms
Chlorine (Cl) 4 atoms

Potassium Binding Sites:

The binding sites of Potassium atom in the K2P2.1 (Trek-1):ML335 Complex, 10 Mm K+ (pdb code 6w8a). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 5 binding sites of Potassium where determined in the K2P2.1 (Trek-1):ML335 Complex, 10 Mm K+, PDB code: 6w8a:
Jump to Potassium binding site number: 1; 2; 3; 4; 5;

Potassium binding site 1 out of 5 in 6w8a

Go back to Potassium Binding Sites List in 6w8a
Potassium binding site 1 out of 5 in the K2P2.1 (Trek-1):ML335 Complex, 10 Mm K+


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of K2P2.1 (Trek-1):ML335 Complex, 10 Mm K+ within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K401

b:107.1
occ:1.00
O A:PHE145 2.8 102.6 1.0
O B:PHE145 2.8 100.2 1.0
O A:PHE254 2.8 105.4 1.0
O B:PHE254 2.9 107.9 1.0
O B:GLY253 3.0 106.4 1.0
O B:GLY144 3.0 93.7 1.0
O A:GLY144 3.1 93.0 1.0
O A:GLY253 3.1 96.4 1.0
C A:PHE145 3.4 101.8 1.0
K B:K402 3.4 127.0 1.0
C B:PHE145 3.5 101.9 1.0
C A:PHE254 3.5 106.0 1.0
C B:PHE254 3.6 107.5 1.0
CA A:PHE254 4.0 100.7 1.0
CA A:PHE145 4.1 96.8 1.0
C B:GLY253 4.1 104.4 1.0
CA B:PHE145 4.1 99.8 1.0
CA B:PHE254 4.1 102.6 1.0
N A:GLY146 4.2 104.8 1.0
C B:GLY144 4.2 95.7 1.0
N B:GLY146 4.2 104.6 1.0
C A:GLY253 4.2 96.7 1.0
C A:GLY144 4.2 94.7 1.0
CA A:GLY146 4.3 108.2 1.0
CA B:GLY146 4.4 106.9 1.0
N A:GLY255 4.4 110.2 1.0
N B:GLY255 4.6 109.2 1.0
N B:PHE254 4.6 103.2 1.0
N A:PHE254 4.6 98.7 1.0
N B:PHE145 4.7 98.1 1.0
N A:PHE145 4.7 95.9 1.0
CA A:GLY255 4.8 114.8 1.0
CA B:GLY255 5.0 111.0 1.0

Potassium binding site 2 out of 5 in 6w8a

Go back to Potassium Binding Sites List in 6w8a
Potassium binding site 2 out of 5 in the K2P2.1 (Trek-1):ML335 Complex, 10 Mm K+


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of K2P2.1 (Trek-1):ML335 Complex, 10 Mm K+ within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K402

b:90.6
occ:1.00
O A:THR251 2.7 89.0 1.0
K B:K402 2.7 127.0 1.0
O B:THR251 2.8 96.1 1.0
O A:ILE252 2.8 91.5 1.0
O A:THR142 2.8 91.6 1.0
O B:THR142 2.8 85.4 1.0
O B:ILE252 2.9 102.5 1.0
O A:ILE143 2.9 90.1 1.0
O B:ILE143 2.9 88.7 1.0
K A:K408 3.6 112.5 1.0
C A:ILE252 3.6 92.1 1.0
C B:ILE252 3.6 102.6 1.0
C A:ILE143 3.7 92.0 1.0
C B:ILE143 3.7 91.0 1.0
C A:THR251 3.9 89.7 1.0
C B:THR251 3.9 95.4 1.0
C A:THR142 4.0 92.9 1.0
C B:THR142 4.0 86.2 1.0
CA A:ILE143 4.2 93.8 1.0
CA A:ILE252 4.2 92.1 1.0
CA B:ILE252 4.2 99.9 1.0
CA B:ILE143 4.3 89.9 1.0
N B:GLY253 4.5 103.0 1.0
N A:ILE252 4.5 90.1 1.0
N A:ILE143 4.6 93.6 1.0
N A:GLY253 4.6 93.3 1.0
N B:ILE252 4.6 98.1 1.0
N B:GLY144 4.6 92.9 1.0
N A:GLY144 4.6 93.1 1.0
N B:ILE143 4.6 88.4 1.0
CA B:GLY253 4.7 104.1 1.0
O A:GLY253 4.7 96.4 1.0
O B:GLY144 4.8 93.7 1.0
CA A:GLY253 4.8 94.9 1.0
O A:GLY144 4.9 93.0 1.0
CA B:GLY144 4.9 94.5 1.0
O B:GLY253 4.9 106.4 1.0
CA A:GLY144 4.9 94.3 1.0
CA A:THR251 5.0 89.3 1.0

Potassium binding site 3 out of 5 in 6w8a

Go back to Potassium Binding Sites List in 6w8a
Potassium binding site 3 out of 5 in the K2P2.1 (Trek-1):ML335 Complex, 10 Mm K+


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of K2P2.1 (Trek-1):ML335 Complex, 10 Mm K+ within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K408

b:112.5
occ:1.00
O A:THR251 2.8 89.0 1.0
O B:THR251 3.0 96.1 1.0
OG1 A:THR251 3.0 91.6 1.0
O B:THR142 3.1 85.4 1.0
O A:THR142 3.1 91.6 1.0
OG1 B:THR251 3.1 91.1 1.0
OG1 B:THR142 3.2 80.7 1.0
CB A:THR251 3.3 90.7 1.0
OG1 A:THR142 3.4 98.5 1.0
CB B:THR251 3.5 90.8 1.0
K A:K402 3.6 90.6 1.0
CB B:THR142 3.6 82.4 1.0
CB A:THR142 3.7 95.2 1.0
C A:THR251 3.7 89.7 1.0
C B:THR251 3.9 95.4 1.0
C B:THR142 3.9 86.2 1.0
C A:THR142 4.0 92.9 1.0
CA A:THR251 4.2 89.3 1.0
CA B:THR251 4.3 92.8 1.0
CA B:THR142 4.4 84.8 1.0
CA A:THR142 4.5 92.5 1.0
CG2 A:THR251 4.6 90.7 1.0
CG2 B:THR251 4.6 90.8 1.0
CG2 B:THR142 4.8 82.5 1.0
N A:ILE252 4.8 90.1 1.0
O A:THR250 4.9 87.4 1.0
N B:ILE252 4.9 98.1 1.0
N B:ILE143 4.9 88.4 1.0
CG2 A:THR142 5.0 95.1 1.0
N A:ILE143 5.0 93.6 1.0

Potassium binding site 4 out of 5 in 6w8a

Go back to Potassium Binding Sites List in 6w8a
Potassium binding site 4 out of 5 in the K2P2.1 (Trek-1):ML335 Complex, 10 Mm K+


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of K2P2.1 (Trek-1):ML335 Complex, 10 Mm K+ within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K402

b:127.0
occ:1.00
K A:K402 2.7 90.6 1.0
O B:ILE252 2.8 102.5 1.0
O B:GLY253 2.8 106.4 1.0
O A:GLY253 2.8 96.4 1.0
O B:GLY144 2.8 93.7 1.0
O A:GLY144 2.8 93.0 1.0
O A:ILE143 2.9 90.1 1.0
O A:ILE252 2.9 91.5 1.0
O B:ILE143 2.9 88.7 1.0
K A:K401 3.4 107.1 1.0
C B:GLY253 3.5 104.4 1.0
C A:GLY144 3.6 94.7 1.0
C B:GLY144 3.7 95.7 1.0
C A:GLY253 3.7 96.7 1.0
C B:ILE252 3.9 102.6 1.0
CA B:GLY253 3.9 104.1 1.0
C A:ILE143 4.0 92.0 1.0
C B:ILE143 4.0 91.0 1.0
C A:ILE252 4.0 92.1 1.0
CA B:GLY144 4.1 94.5 1.0
CA A:GLY144 4.1 94.3 1.0
CA A:GLY253 4.2 94.9 1.0
N B:GLY253 4.4 103.0 1.0
N B:PHE254 4.5 103.2 1.0
N A:GLY144 4.5 93.1 1.0
N B:GLY144 4.5 92.9 1.0
N A:GLY253 4.6 93.3 1.0
N A:PHE145 4.6 95.9 1.0
N B:PHE145 4.7 98.1 1.0
N A:PHE254 4.7 98.7 1.0
O B:THR251 4.9 96.1 1.0
O A:THR142 4.9 91.6 1.0
CA A:PHE145 4.9 96.8 1.0
O B:THR142 4.9 85.4 1.0
O A:THR251 5.0 89.0 1.0
CA B:PHE254 5.0 102.6 1.0
CA B:PHE145 5.0 99.8 1.0

Potassium binding site 5 out of 5 in 6w8a

Go back to Potassium Binding Sites List in 6w8a
Potassium binding site 5 out of 5 in the K2P2.1 (Trek-1):ML335 Complex, 10 Mm K+


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 5 of K2P2.1 (Trek-1):ML335 Complex, 10 Mm K+ within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K413

b:190.0
occ:1.00
OD1 B:ASN111 3.3 197.0 1.0
CG2 A:ILE110 4.4 173.0 1.0
CG B:ASN111 4.5 194.7 1.0
CG2 B:ILE110 5.0 181.2 1.0

Reference:

M.Lolicato, A.M.Natale, F.Abderemane-Ali, D.Crottes, S.Capponi, R.Duman, A.Wagner, J.M.Rosenberg, M.Grabe, D.L.Minor Jr.. K 2P Channel C-Type Gating Involves Asymmetric Selectivity Filter Order-Disorder Transitions. Sci Adv V. 6 2020.
ISSN: ESSN 2375-2548
PubMed: 33127683
DOI: 10.1126/SCIADV.ABC9174
Page generated: Wed Mar 3 14:16:33 2021

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