Potassium in PDB 6v7h: Structure of Ctx-M-14 Bound to Vaborbactam at 1.0 A

All present enzymatic activity of Structure of Ctx-M-14 Bound to Vaborbactam at 1.0 A:
3.5.2.6;

The structure of Structure of Ctx-M-14 Bound to Vaborbactam at 1.0 A, PDB code: 6v7h was solved by O.A.Pemberton, Y.Chen, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	46.88 / 1.00
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	45.300, 106.695, 47.865, 90.00, 101.64, 90.00
R / Rfree (%)	10.4 / 12.1

The binding sites of Potassium atom in the Structure of Ctx-M-14 Bound to Vaborbactam at 1.0 A (pdb code 6v7h). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Structure of Ctx-M-14 Bound to Vaborbactam at 1.0 A, PDB code: 6v7h:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in the Structure of Ctx-M-14 Bound to Vaborbactam at 1.0 A


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Structure of Ctx-M-14 Bound to Vaborbactam at 1.0 A within 5.0Å range: probe atom residue distance (Å) B Occ A:K304 b:36.0 occ:1.00 O A:HOH728 2.6 23.4 1.0 HB3 A:ALA150 2.7 7.2 1.0 O A:GLY147 2.7 6.0 1.0 O A:HOH843 2.8 21.8 1.0 O A:HOH749 2.8 21.3 1.0 O A:HOH568 3.0 39.1 1.0 HA2 A:GLY147 3.3 6.3 1.0 H A:PHE151 3.4 6.3 1.0 HB2 A:PHE151 3.5 6.8 1.0 CB A:ALA150 3.6 6.0 1.0 C A:GLY147 3.6 5.3 1.0 HB1 A:ALA150 3.7 7.2 1.0 N A:PHE151 3.7 5.3 1.0 CA A:GLY147 3.8 5.3 1.0 HA3 A:GLY147 3.9 6.3 1.0 HD22 A:LEU142 4.2 8.7 1.0 HA A:PHE151 4.2 6.4 1.0 HB2 A:ALA150 4.2 7.2 1.0 C A:ALA150 4.2 5.0 1.0 CB A:PHE151 4.3 5.7 1.0 CA A:PHE151 4.3 5.3 1.0 O A:HOH872 4.4 26.9 1.0 HB3 A:LEU142 4.4 7.0 1.0 O A:HOH625 4.4 16.8 1.0 CA A:ALA150 4.4 5.4 1.0 HB3 A:PHE151 4.6 6.8 1.0 H A:ALA150 4.6 6.0 1.0 O A:HOH881 4.7 34.1 1.0 O A:HOH695 4.7 20.6 1.0 O A:HOH789 4.8 27.9 1.0 HB1 A:ALA79 4.8 6.0 1.0 O A:LEU142 4.8 6.8 1.0 N A:VAL148 4.9 5.2 1.0 N A:ALA150 4.9 5.0 1.0 O A:ALA150 5.0 5.4 1.0

Potassium binding site 2 out of 2 in the Structure of Ctx-M-14 Bound to Vaborbactam at 1.0 A


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Structure of Ctx-M-14 Bound to Vaborbactam at 1.0 A within 5.0Å range: probe atom residue distance (Å) B Occ B:K305 b:95.9 occ:1.00 O B:HOH907 2.7 43.6 1.0 O B:HOH498 2.8 18.4 1.0 O B:HOH696 3.6 31.0 1.0 HA2 B:GLY143 4.0 7.9 1.0 O B:HOH818 4.2 41.1 1.0 O B:ALA140 4.6 6.2 1.0 O B:HOH800 4.6 17.6 1.0 O B:HOH504 4.7 20.8 1.0 O B:HOH759 4.8 27.2 1.0 O B:HOH775 4.9 42.0 1.0 CA B:GLY143 5.0 6.6 1.0

O.A.Pemberton, R.Tsivkovski, M.Totrov, O.Lomovskaya, Y.Chen. Structural Basis and Binding Kinetics of Vaborbactam in Class A Beta-Lactamase Inhibition. Antimicrob.Agents Chemother. V. 64 2020.
ISSN: ESSN 1098-6596
PubMed: 32778546
DOI: 10.1128/AAC.00398-20