Atomistry » Potassium » PDB 6u9t-6v7h » 6v3c
Atomistry »
  Potassium »
    PDB 6u9t-6v7h »
      6v3c »

Potassium in PDB 6v3c: K2P2.1(Trek-1)I110D:RU360 Bound Channel Structure

Protein crystallography data

The structure of K2P2.1(Trek-1)I110D:RU360 Bound Channel Structure, PDB code: 6v3c was solved by L.Pope, M.Lolicato, D.L.Minor, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 14.98 / 3.51
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 67.737, 120.708, 127.274, 90.00, 90.00, 90.00
R / Rfree (%) 30.2 / 32.5

Other elements in 6v3c:

The structure of K2P2.1(Trek-1)I110D:RU360 Bound Channel Structure also contains other interesting chemical elements:

Ruthenium (Ru) 2 atoms
Cadmium (Cd) 3 atoms

Potassium Binding Sites:

The binding sites of Potassium atom in the K2P2.1(Trek-1)I110D:RU360 Bound Channel Structure (pdb code 6v3c). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 5 binding sites of Potassium where determined in the K2P2.1(Trek-1)I110D:RU360 Bound Channel Structure, PDB code: 6v3c:
Jump to Potassium binding site number: 1; 2; 3; 4; 5;

Potassium binding site 1 out of 5 in 6v3c

Go back to Potassium Binding Sites List in 6v3c
Potassium binding site 1 out of 5 in the K2P2.1(Trek-1)I110D:RU360 Bound Channel Structure


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of K2P2.1(Trek-1)I110D:RU360 Bound Channel Structure within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K403

b:0.3
occ:1.00
O A:THR142 2.7 0.6 1.0
O A:THR251 2.7 0.5 1.0
O A:ILE252 2.8 0.7 1.0
O B:THR142 2.8 0.1 1.0
O B:THR251 2.9 0.9 1.0
O A:ILE143 2.9 0.9 1.0
O B:ILE252 2.9 1.0 1.0
K A:K404 3.1 0.7 1.0
O B:ILE143 3.2 0.6 1.0
C A:ILE252 3.5 0.5 1.0
C A:ILE143 3.6 0.6 1.0
C A:THR251 3.6 0.1 1.0
C B:ILE143 3.7 0.0 1.0
K B:K403 3.7 0.7 1.0
C B:ILE252 3.7 0.7 1.0
C A:THR142 3.8 0.5 1.0
CA A:ILE252 3.8 0.8 1.0
CA A:ILE143 3.8 0.5 1.0
C B:THR142 3.9 0.7 1.0
C B:THR251 3.9 0.6 1.0
CA B:ILE143 3.9 0.9 1.0
CA B:ILE252 4.1 0.1 1.0
N A:ILE252 4.1 0.9 1.0
N A:ILE143 4.3 0.7 1.0
N B:ILE143 4.4 0.8 1.0
N B:ILE252 4.4 0.5 1.0
N B:GLY144 4.6 0.6 1.0
N A:GLY253 4.6 0.5 1.0
N A:GLY144 4.7 0.1 1.0
CA A:THR251 4.8 0.1 1.0
N B:GLY253 4.8 0.1 1.0
CA A:THR142 5.0 1.0 1.0

Potassium binding site 2 out of 5 in 6v3c

Go back to Potassium Binding Sites List in 6v3c
Potassium binding site 2 out of 5 in the K2P2.1(Trek-1)I110D:RU360 Bound Channel Structure


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of K2P2.1(Trek-1)I110D:RU360 Bound Channel Structure within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K404

b:0.7
occ:1.00
O A:ILE252 2.7 0.7 1.0
O B:GLY144 2.7 0.6 1.0
O B:ILE252 2.7 1.0 1.0
O A:ILE143 2.7 0.9 1.0
O A:GLY253 2.7 0.9 1.0
O B:GLY253 2.8 0.1 1.0
O B:ILE143 2.8 0.6 1.0
O A:GLY144 2.8 0.4 1.0
K A:K403 3.1 0.3 1.0
K B:K404 3.1 0.4 1.0
C B:GLY144 3.5 0.6 1.0
C A:GLY253 3.6 0.6 1.0
C A:GLY144 3.7 0.1 1.0
C B:GLY253 3.7 0.6 1.0
C B:ILE143 3.9 0.0 1.0
C A:ILE252 3.9 0.5 1.0
C A:ILE143 3.9 0.6 1.0
C B:ILE252 3.9 0.7 1.0
CA B:GLY144 4.1 0.7 1.0
CA A:GLY253 4.2 0.7 1.0
CA B:GLY253 4.2 0.9 1.0
CA A:GLY144 4.3 0.6 1.0
N B:GLY144 4.4 0.6 1.0
N B:PHE145 4.5 0.8 1.0
N A:GLY253 4.5 0.5 1.0
N A:GLY144 4.5 0.1 1.0
N B:GLY253 4.5 0.1 1.0
N A:PHE254 4.6 0.1 1.0
N A:PHE145 4.6 0.5 1.0
N B:PHE254 4.7 0.4 1.0
CA B:PHE145 4.8 0.2 1.0
CA A:PHE254 4.8 0.2 1.0
CA A:PHE145 4.9 0.1 1.0
CA B:PHE254 5.0 0.1 1.0

Potassium binding site 3 out of 5 in 6v3c

Go back to Potassium Binding Sites List in 6v3c
Potassium binding site 3 out of 5 in the K2P2.1(Trek-1)I110D:RU360 Bound Channel Structure


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of K2P2.1(Trek-1)I110D:RU360 Bound Channel Structure within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K405

b:0.1
occ:1.00
O B:HOH501 3.3 0.9 1.0
O A:HOH501 3.8 0.6 1.0
OG1 A:THR142 3.8 0.8 1.0
OG1 B:THR251 4.2 0.1 1.0
K B:K403 4.4 0.7 1.0
OG1 A:THR251 4.6 0.2 1.0
CB A:THR142 4.9 0.3 1.0

Potassium binding site 4 out of 5 in 6v3c

Go back to Potassium Binding Sites List in 6v3c
Potassium binding site 4 out of 5 in the K2P2.1(Trek-1)I110D:RU360 Bound Channel Structure


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of K2P2.1(Trek-1)I110D:RU360 Bound Channel Structure within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K403

b:0.7
occ:1.00
O A:THR251 2.7 0.5 1.0
O B:THR142 2.8 0.1 1.0
O B:THR251 2.9 0.9 1.0
OG1 B:THR142 3.0 0.3 1.0
OG1 A:THR251 3.1 0.2 1.0
O A:THR142 3.2 0.6 1.0
CB A:THR251 3.3 0.2 1.0
CB B:THR251 3.3 0.2 1.0
OG1 B:THR251 3.4 0.1 1.0
CB B:THR142 3.4 0.1 1.0
OG1 A:THR142 3.5 0.8 1.0
C A:THR251 3.7 0.1 1.0
K A:K403 3.7 0.3 1.0
C B:THR142 3.7 0.7 1.0
CB A:THR142 3.9 0.3 1.0
C B:THR251 3.9 0.6 1.0
CA A:THR251 4.1 0.1 1.0
C A:THR142 4.2 0.5 1.0
CA B:THR251 4.2 0.9 1.0
CA B:THR142 4.2 0.5 1.0
K A:K405 4.4 0.1 1.0
CG2 B:THR251 4.4 0.5 1.0
CG2 A:THR251 4.5 0.2 1.0
CG2 B:THR142 4.7 0.2 1.0
CA A:THR142 4.7 1.0 1.0
O B:THR141 4.8 0.7 1.0
N B:ILE143 4.8 0.8 1.0
N A:ILE252 4.8 0.9 1.0
O A:THR250 4.9 0.5 1.0

Potassium binding site 5 out of 5 in 6v3c

Go back to Potassium Binding Sites List in 6v3c
Potassium binding site 5 out of 5 in the K2P2.1(Trek-1)I110D:RU360 Bound Channel Structure


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 5 of K2P2.1(Trek-1)I110D:RU360 Bound Channel Structure within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K404

b:0.4
occ:1.00
O A:PHE145 2.8 0.8 1.0
O A:GLY144 2.9 0.4 1.0
O B:PHE145 2.9 0.8 1.0
O B:PHE254 2.9 0.9 1.0
O A:PHE254 2.9 0.5 1.0
O B:GLY253 2.9 0.1 1.0
O B:GLY144 3.0 0.6 1.0
O A:GLY253 3.0 0.9 1.0
K A:K404 3.1 0.7 1.0
C A:PHE145 3.3 1.0 1.0
C B:PHE145 3.5 0.5 1.0
C B:PHE254 3.5 0.4 1.0
C A:PHE254 3.5 0.8 1.0
CA B:PHE254 3.9 0.1 1.0
CA A:PHE254 3.9 0.2 1.0
CA A:PHE145 4.0 0.1 1.0
C A:GLY144 4.0 0.1 1.0
N A:GLY146 4.0 0.9 1.0
C B:GLY253 4.0 0.6 1.0
CA B:PHE145 4.1 0.2 1.0
C A:GLY253 4.1 0.6 1.0
C B:GLY144 4.1 0.6 1.0
N B:GLY146 4.2 0.7 1.0
CA A:GLY146 4.3 0.5 1.0
N B:GLY255 4.4 0.5 1.0
N A:GLY255 4.4 0.4 1.0
N B:PHE254 4.5 0.4 1.0
N A:PHE145 4.5 0.5 1.0
CA B:GLY146 4.5 0.6 1.0
N A:PHE254 4.5 0.1 1.0
N B:PHE145 4.6 0.8 1.0
CA B:GLY255 4.9 0.4 1.0
CA A:GLY255 4.9 0.8 1.0

Reference:

L.Pope, M.Lolicato, D.L.Minor Jr.. Polynuclear Ruthenium Amines Inhibit K2PCHANNELS Via A "Finger in the Dam" Mechanism. Cell Chem Biol 2020.
ISSN: ESSN 2451-9456
PubMed: 32059793
DOI: 10.1016/J.CHEMBIOL.2020.01.011
Page generated: Mon Dec 14 02:00:20 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy