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Potassium in PDB 6v36: K2P2.1(Trek-1)I110D Apo Channel Structure

Protein crystallography data

The structure of K2P2.1(Trek-1)I110D Apo Channel Structure, PDB code: 6v36 was solved by L.Pope, M.Lolicato, D.L.Minor, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 14.98 / 3.40
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 68.192, 120.400, 128.355, 90.00, 90.00, 90.00
R / Rfree (%) 28.6 / 31.8

Other elements in 6v36:

The structure of K2P2.1(Trek-1)I110D Apo Channel Structure also contains other interesting chemical elements:

Cadmium (Cd) 3 atoms

Potassium Binding Sites:

The binding sites of Potassium atom in the K2P2.1(Trek-1)I110D Apo Channel Structure (pdb code 6v36). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 6 binding sites of Potassium where determined in the K2P2.1(Trek-1)I110D Apo Channel Structure, PDB code: 6v36:
Jump to Potassium binding site number: 1; 2; 3; 4; 5; 6;

Potassium binding site 1 out of 6 in 6v36

Go back to Potassium Binding Sites List in 6v36
Potassium binding site 1 out of 6 in the K2P2.1(Trek-1)I110D Apo Channel Structure


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of K2P2.1(Trek-1)I110D Apo Channel Structure within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K405

b:0.7
occ:1.00
 O A:GLY146 4.3 0.5 1.0
OD1 A:ASP110 4.7 0.0 1.0
C A:GLY146 4.9 0.2 1.0

Potassium binding site 2 out of 6 in 6v36

Go back to Potassium Binding Sites List in 6v36
Potassium binding site 2 out of 6 in the K2P2.1(Trek-1)I110D Apo Channel Structure


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of K2P2.1(Trek-1)I110D Apo Channel Structure within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K406

b:0.7
occ:1.00
 OG1 A:THR251 2.4 0.9 1.0
O B:THR251 2.5 0.9 1.0
OG1 B:THR251 2.6 0.2 1.0
O A:THR251 2.7 0.3 1.0
O A:THR142 2.7 0.3 1.0
OG1 A:THR142 2.8 0.9 1.0
CB A:THR142 3.3 0.8 1.0
K A:K407 3.3 0.3 1.0
O B:THR142 3.3 0.3 1.0
C A:THR142 3.5 0.3 1.0
CB A:THR251 3.6 0.9 1.0
C B:THR251 3.7 1.0 1.0
OG1 B:THR142 3.7 0.6 1.0
C A:THR251 3.8 0.6 1.0
CB B:THR251 3.9 0.3 1.0
CA A:THR142 4.0 1.0 1.0
CB B:THR142 4.1 0.6 1.0
C B:THR142 4.3 0.2 1.0
CA A:THR251 4.4 0.1 1.0
CA B:THR251 4.4 0.5 1.0
N A:ILE143 4.5 0.1 1.0
O A:THR141 4.5 1.0 1.0
CG2 A:THR142 4.5 0.1 1.0
K B:K405 4.6 0.1 1.0
N B:ILE252 4.7 0.3 1.0
CG2 A:THR251 4.7 1.0 1.0
CG2 B:THR251 4.8 1.0 1.0
CA B:ILE252 4.8 0.8 1.0
CA B:THR142 4.9 0.5 1.0
CA A:ILE143 4.9 0.1 1.0
N A:ILE252 5.0 0.5 1.0

Potassium binding site 3 out of 6 in 6v36

Go back to Potassium Binding Sites List in 6v36
Potassium binding site 3 out of 6 in the K2P2.1(Trek-1)I110D Apo Channel Structure


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of K2P2.1(Trek-1)I110D Apo Channel Structure within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K407

b:0.3
occ:1.00
 O B:THR142 2.6 0.3 1.0
O A:THR142 2.7 0.3 1.0
O A:ILE252 2.8 0.9 1.0
O A:THR251 2.8 0.3 1.0
O B:ILE143 2.8 0.5 1.0
O B:ILE252 2.9 0.7 1.0
O A:ILE143 3.0 0.4 1.0
O B:THR251 3.1 0.9 1.0
K A:K408 3.2 0.8 1.0
K A:K406 3.3 0.7 1.0
C A:ILE252 3.5 0.6 1.0
C B:ILE143 3.6 0.1 1.0
C B:ILE252 3.7 0.2 1.0
C A:ILE143 3.7 0.5 1.0
C B:THR142 3.8 0.2 1.0
C A:THR251 3.8 0.6 1.0
CA A:ILE252 3.8 0.9 1.0
C A:THR142 3.8 0.3 1.0
CA B:ILE143 4.0 0.1 1.0
CA A:ILE143 4.0 0.1 1.0
C B:THR251 4.1 1.0 1.0
CA B:ILE252 4.1 0.8 1.0
N A:ILE252 4.3 0.5 1.0
N B:ILE143 4.4 0.5 1.0
N A:ILE143 4.4 0.1 1.0
N B:ILE252 4.5 0.3 1.0
OG1 A:THR251 4.5 0.9 1.0
OG1 B:THR251 4.6 0.2 1.0
N A:GLY253 4.6 0.5 1.0
N B:GLY144 4.7 0.6 1.0
N B:GLY253 4.8 0.7 1.0
N A:GLY144 4.9 0.3 1.0
CA B:THR142 5.0 0.5 1.0
CA A:THR251 5.0 0.1 1.0

Potassium binding site 4 out of 6 in 6v36

Go back to Potassium Binding Sites List in 6v36
Potassium binding site 4 out of 6 in the K2P2.1(Trek-1)I110D Apo Channel Structure


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of K2P2.1(Trek-1)I110D Apo Channel Structure within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K408

b:0.8
occ:1.00
 O B:GLY253 2.7 0.3 1.0
O A:ILE143 2.7 0.4 1.0
O A:ILE252 2.7 0.9 1.0
O A:GLY253 2.8 0.7 1.0
O B:GLY144 2.8 0.2 1.0
O B:ILE143 2.8 0.5 1.0
O B:ILE252 2.8 0.7 1.0
O A:GLY144 2.8 0.2 1.0
K A:K409 2.9 0.8 0.4
K A:K407 3.2 0.3 1.0
C B:GLY253 3.6 0.6 1.0
C B:GLY144 3.6 0.6 1.0
C A:GLY253 3.6 0.9 1.0
C A:GLY144 3.7 0.2 1.0
C A:ILE143 3.9 0.5 1.0
C A:ILE252 3.9 0.6 1.0
C B:ILE143 4.0 0.1 1.0
C B:ILE252 4.0 0.2 1.0
CA B:GLY253 4.2 0.1 1.0
CA A:GLY253 4.2 0.8 1.0
CA A:GLY144 4.3 0.5 1.0
CA B:GLY144 4.3 0.5 1.0
N B:PHE145 4.5 0.2 1.0
N A:GLY253 4.5 0.5 1.0
N B:GLY253 4.5 0.7 1.0
N A:PHE145 4.6 0.2 1.0
N A:GLY144 4.6 0.3 1.0
N B:PHE254 4.6 0.5 1.0
N B:GLY144 4.6 0.6 1.0
N A:PHE254 4.6 0.3 1.0
CA B:PHE145 4.7 0.8 1.0
CA A:PHE145 4.8 0.1 1.0
CA B:PHE254 4.9 0.1 1.0
CA A:PHE254 5.0 0.2 1.0
O B:PHE254 5.0 0.3 1.0
C B:PHE145 5.0 0.4 1.0

Potassium binding site 5 out of 6 in 6v36

Go back to Potassium Binding Sites List in 6v36
Potassium binding site 5 out of 6 in the K2P2.1(Trek-1)I110D Apo Channel Structure


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 5 of K2P2.1(Trek-1)I110D Apo Channel Structure within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K409

b:0.8
occ:0.40
 O A:PHE254 2.7 0.9 1.0
O A:GLY253 2.8 0.7 1.0
O B:PHE254 2.8 0.3 1.0
O B:PHE145 2.8 0.1 1.0
O A:PHE145 2.9 0.2 1.0
O A:GLY144 2.9 0.2 1.0
O B:GLY144 2.9 0.2 1.0
O B:GLY253 2.9 0.3 1.0
K A:K408 2.9 0.8 1.0
C B:PHE145 3.3 0.4 1.0
C A:PHE145 3.4 0.0 1.0
C A:PHE254 3.5 0.4 1.0
C B:PHE254 3.6 0.3 1.0
C A:GLY253 3.9 0.9 1.0
CA A:PHE254 3.9 0.2 1.0
CA A:PHE145 3.9 0.1 1.0
CA B:PHE145 3.9 0.8 1.0
C A:GLY144 4.0 0.2 1.0
C B:GLY144 4.0 0.6 1.0
CA B:PHE254 4.0 0.1 1.0
C B:GLY253 4.1 0.6 1.0
N B:GLY146 4.1 0.2 1.0
N A:GLY146 4.2 0.5 1.0
N A:PHE254 4.4 0.3 1.0
CA B:GLY146 4.4 0.3 1.0
N A:PHE145 4.4 0.2 1.0
N B:PHE145 4.5 0.2 1.0
N A:GLY255 4.5 0.1 1.0
N B:PHE254 4.6 0.5 1.0
N B:GLY255 4.6 0.7 1.0
CA A:GLY146 4.6 0.7 1.0
O A:ILE143 4.9 0.4 1.0
O A:ILE252 5.0 0.9 1.0
CA A:GLY255 5.0 0.7 1.0

Potassium binding site 6 out of 6 in 6v36

Go back to Potassium Binding Sites List in 6v36
Potassium binding site 6 out of 6 in the K2P2.1(Trek-1)I110D Apo Channel Structure


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 6 of K2P2.1(Trek-1)I110D Apo Channel Structure within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K405

b:0.1
occ:1.00
 O B:HOH502 2.9 0.4 1.0
O A:HOH501 3.5 0.9 1.0
OG1 A:THR142 4.4 0.9 1.0
OG1 B:THR251 4.5 0.2 1.0
K A:K406 4.6 0.7 1.0
OG1 A:THR251 4.6 0.9 1.0
CG2 B:THR251 4.8 1.0 1.0
OG1 B:THR142 4.8 0.6 1.0

Reference:

L.Pope, M.Lolicato, D.L.Minor Jr.. Polynuclear Ruthenium Amines Inhibit K2PCHANNELS Via A "Finger in the Dam" Mechanism. Cell Chem Biol 2020.
ISSN: ESSN 2451-9456
PubMed: 32059793
DOI: 10.1016/J.CHEMBIOL.2020.01.011
Page generated: Mon Aug 12 17:53:23 2024

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