Potassium in PDB 6sbi: X-Ray Structure of Murine Fumarylacetoacetate Hydrolase Domain Containing Protein 1 (FAHD1) in Complex with Inhibitor Oxalate

Enzymatic activity of X-Ray Structure of Murine Fumarylacetoacetate Hydrolase Domain Containing Protein 1 (FAHD1) in Complex with Inhibitor Oxalate

All present enzymatic activity of X-Ray Structure of Murine Fumarylacetoacetate Hydrolase Domain Containing Protein 1 (FAHD1) in Complex with Inhibitor Oxalate:
3.7.1.5; 4.1.1.112;

Protein crystallography data

The structure of X-Ray Structure of Murine Fumarylacetoacetate Hydrolase Domain Containing Protein 1 (FAHD1) in Complex with Inhibitor Oxalate, PDB code: 6sbi was solved by B.Rupp, A.Naschberger, A.K.H.Weiss, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 44.37 / 2.70
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 52.603, 103.348, 86.597, 90.00, 90.21, 90.00
R / Rfree (%) 18.7 / 23.4

Other elements in 6sbi:

The structure of X-Ray Structure of Murine Fumarylacetoacetate Hydrolase Domain Containing Protein 1 (FAHD1) in Complex with Inhibitor Oxalate also contains other interesting chemical elements:

Magnesium (Mg) 4 atoms
Chlorine (Cl) 9 atoms

Potassium Binding Sites:

The binding sites of Potassium atom in the X-Ray Structure of Murine Fumarylacetoacetate Hydrolase Domain Containing Protein 1 (FAHD1) in Complex with Inhibitor Oxalate (pdb code 6sbi). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the X-Ray Structure of Murine Fumarylacetoacetate Hydrolase Domain Containing Protein 1 (FAHD1) in Complex with Inhibitor Oxalate, PDB code: 6sbi:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in 6sbi

Go back to Potassium Binding Sites List in 6sbi
Potassium binding site 1 out of 2 in the X-Ray Structure of Murine Fumarylacetoacetate Hydrolase Domain Containing Protein 1 (FAHD1) in Complex with Inhibitor Oxalate


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of X-Ray Structure of Murine Fumarylacetoacetate Hydrolase Domain Containing Protein 1 (FAHD1) in Complex with Inhibitor Oxalate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K302

b:27.8
occ:1.00
 O B:LYS21 2.8 14.7 1.0
O A:HOH402 2.8 23.8 1.0
OD1 B:ASN22 3.1 21.0 1.0
O A:LYS21 3.1 16.0 1.0
O B:HOH412 3.1 32.9 1.0
OD1 A:ASN22 3.2 22.9 1.0
CA B:ASN22 3.7 19.9 1.0
C B:LYS21 3.8 16.8 1.0
CG B:ASN22 4.0 20.9 1.0
C A:LYS21 4.1 18.0 1.0
CA A:ASN22 4.1 19.4 1.0
O B:LYS50 4.2 14.4 1.0
CB B:ASN22 4.2 21.4 1.0
CG A:ASN22 4.2 23.6 1.0
N B:ASN22 4.2 18.9 1.0
CA B:PRO51 4.3 13.3 1.0
N B:SER52 4.4 14.4 1.0
O A:LYS50 4.4 14.8 1.0
CA A:PRO51 4.5 13.9 1.0
CB A:ASN22 4.5 21.5 1.0
N A:SER52 4.6 13.8 1.0
N A:ASN22 4.6 18.9 1.0
N B:ILE23 4.7 17.3 1.0
C B:PRO51 4.7 13.9 1.0
C B:ASN22 4.8 18.1 1.0
C A:PRO51 5.0 13.4 1.0

Potassium binding site 2 out of 2 in 6sbi

Go back to Potassium Binding Sites List in 6sbi
Potassium binding site 2 out of 2 in the X-Ray Structure of Murine Fumarylacetoacetate Hydrolase Domain Containing Protein 1 (FAHD1) in Complex with Inhibitor Oxalate


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of X-Ray Structure of Murine Fumarylacetoacetate Hydrolase Domain Containing Protein 1 (FAHD1) in Complex with Inhibitor Oxalate within 5.0Å range:
probe atom residue distance (Å) B Occ
C:K302

b:41.5
occ:1.00
 O D:HOH404 2.7 28.5 1.0
O C:HOH405 2.8 14.7 1.0
O C:LYS21 2.8 14.8 1.0
OD1 C:ASN22 3.0 17.7 1.0
O D:LYS21 3.1 17.3 1.0
OD1 D:ASN22 3.2 23.6 1.0
CA C:ASN22 3.8 16.4 1.0
C C:LYS21 3.8 16.7 1.0
CG C:ASN22 3.9 18.8 1.0
C D:LYS21 4.1 16.5 1.0
CA D:ASN22 4.1 16.7 1.0
CB C:ASN22 4.2 17.3 1.0
CG D:ASN22 4.2 22.5 1.0
N C:ASN22 4.2 17.1 1.0
O C:LYS50 4.2 18.8 1.0
O D:LYS50 4.3 12.6 1.0
CA D:PRO51 4.4 13.0 1.0
CA C:PRO51 4.4 14.8 1.0
N C:SER52 4.4 15.7 1.0
N D:SER52 4.5 14.1 1.0
CB D:ASN22 4.5 19.3 1.0
N D:ASN22 4.6 16.2 1.0
N C:ILE23 4.8 14.8 1.0
C C:PRO51 4.8 15.2 1.0
C C:ASN22 4.8 14.8 1.0
C D:PRO51 4.9 13.0 1.0

Reference:

A.K.H.Weiss, A.Naschberger, E.Cappuccio, C.Metzger, L.Mottes, M.Holzknecht, J.Von Velsen, M.W.Bowler, B.Rupp, P.Jansen-Durr. Structural and Functional Comparison of Fumarylacetoacetate Domain Containing Protein 1 in Human and Mouse. Biosci.Rep. V. 40 2020.
ISSN: ISSN 0144-8463
PubMed: 32068790
DOI: 10.1042/BSR20194431
Page generated: Mon Dec 14 01:31:07 2020

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