Potassium in PDB 6rv4: Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237
Protein crystallography data
The structure of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237, PDB code: 6rv4
was solved by
K.E.J.Rodstrom,
A.C.W.Pike,
W.Zhang,
A.Quigley,
D.Speedman,
S.M.M.Mukhopadhyay,
L.Shrestha,
R.Chalk,
S.Venkaya,
S.R.Bushell,
A.Tessitore,
N.Burgess-Brown,
C.H.Arrowsmith,
A.M.Edwards,
C.Bountra,
E.P.Carpenter,
Structural Genomics Consortium (Sgc),
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Resolution Low / High (Å)
|
41.16 /
3.10
|
Space group
|
P 2 21 21
|
Cell size a, b, c (Å), α, β, γ (°)
|
45.100,
201.330,
238.570,
90.00,
90.00,
90.00
|
R / Rfree (%)
|
25 /
25.6
|
Other elements in 6rv4:
The structure of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237 also contains other interesting chemical elements:
Potassium Binding Sites:
The binding sites of Potassium atom in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237
(pdb code 6rv4). This binding sites where shown within
5.0 Angstroms radius around Potassium atom.
In total 8 binding sites of Potassium where determined in the
Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237, PDB code: 6rv4:
Jump to Potassium binding site number:
1;
2;
3;
4;
5;
6;
7;
8;
Potassium binding site 1 out
of 8 in 6rv4
Go back to
Potassium Binding Sites List in 6rv4
Potassium binding site 1 out
of 8 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237
Mono view
Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 1 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:K302
b:49.5
occ:1.00
|
O
|
A:GLY201
|
2.6
|
18.2
|
1.0
|
O
|
A:ILE94
|
2.7
|
22.0
|
1.0
|
O
|
A:ILE200
|
2.7
|
17.2
|
1.0
|
O
|
A:GLY95
|
2.7
|
24.9
|
1.0
|
O
|
B:GLY201
|
2.8
|
22.8
|
1.0
|
O
|
B:ILE94
|
2.8
|
17.6
|
1.0
|
O
|
B:GLY95
|
2.8
|
20.1
|
1.0
|
K
|
A:K303
|
2.8
|
32.5
|
1.0
|
O
|
B:ILE200
|
2.8
|
19.5
|
1.0
|
K
|
A:K309
|
3.0
|
19.9
|
1.0
|
C
|
A:GLY201
|
3.5
|
18.5
|
1.0
|
C
|
A:GLY95
|
3.6
|
25.3
|
1.0
|
C
|
B:GLY95
|
3.6
|
20.3
|
1.0
|
C
|
B:GLY201
|
3.6
|
23.5
|
1.0
|
C
|
A:ILE200
|
3.8
|
16.7
|
1.0
|
C
|
A:ILE94
|
3.8
|
22.8
|
1.0
|
C
|
B:ILE94
|
3.9
|
17.8
|
1.0
|
C
|
B:ILE200
|
3.9
|
19.7
|
1.0
|
CA
|
A:GLY201
|
4.0
|
13.3
|
1.0
|
CA
|
A:GLY95
|
4.2
|
20.4
|
1.0
|
CA
|
B:GLY201
|
4.2
|
18.2
|
1.0
|
CA
|
B:GLY95
|
4.2
|
14.8
|
1.0
|
N
|
A:GLY201
|
4.3
|
13.0
|
1.0
|
N
|
A:GLY95
|
4.4
|
20.1
|
1.0
|
N
|
B:GLY201
|
4.5
|
17.7
|
1.0
|
N
|
A:TYR96
|
4.5
|
22.4
|
1.0
|
N
|
B:GLY95
|
4.5
|
14.4
|
1.0
|
N
|
A:PHE202
|
4.5
|
16.0
|
1.0
|
N
|
B:TYR96
|
4.6
|
17.6
|
1.0
|
N
|
B:PHE202
|
4.6
|
21.4
|
1.0
|
CA
|
A:TYR96
|
4.8
|
22.6
|
1.0
|
O
|
A:THR199
|
4.9
|
15.8
|
1.0
|
CA
|
A:PHE202
|
4.9
|
16.1
|
1.0
|
CA
|
B:TYR96
|
4.9
|
17.3
|
1.0
|
O
|
A:THR93
|
4.9
|
23.1
|
1.0
|
O
|
B:THR93
|
4.9
|
17.6
|
1.0
|
O
|
B:THR199
|
4.9
|
14.8
|
1.0
|
CA
|
B:PHE202
|
5.0
|
21.8
|
1.0
|
|
Potassium binding site 2 out
of 8 in 6rv4
Go back to
Potassium Binding Sites List in 6rv4
Potassium binding site 2 out
of 8 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237
Mono view
Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 2 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:K303
b:32.5
occ:1.00
|
O
|
B:THR93
|
2.7
|
17.6
|
1.0
|
O
|
A:THR199
|
2.7
|
15.8
|
1.0
|
O
|
B:THR199
|
2.7
|
14.8
|
1.0
|
O
|
A:THR93
|
2.7
|
23.1
|
1.0
|
O
|
B:ILE94
|
2.7
|
17.6
|
1.0
|
O
|
A:ILE94
|
2.7
|
22.0
|
1.0
|
K
|
A:K302
|
2.8
|
49.5
|
1.0
|
O
|
B:ILE200
|
2.8
|
19.5
|
1.0
|
O
|
A:ILE200
|
2.8
|
17.2
|
1.0
|
C
|
B:ILE94
|
3.5
|
17.8
|
1.0
|
C
|
A:ILE94
|
3.5
|
22.8
|
1.0
|
C
|
B:ILE200
|
3.6
|
19.7
|
1.0
|
C
|
A:ILE200
|
3.6
|
16.7
|
1.0
|
K
|
A:K304
|
3.6
|
20.9
|
1.0
|
C
|
A:THR199
|
3.8
|
16.3
|
1.0
|
C
|
B:THR93
|
3.8
|
17.8
|
1.0
|
C
|
B:THR199
|
3.8
|
16.1
|
1.0
|
C
|
A:THR93
|
3.8
|
23.3
|
1.0
|
CA
|
B:ILE94
|
4.0
|
13.4
|
1.0
|
CA
|
A:ILE94
|
4.0
|
18.0
|
1.0
|
CA
|
A:ILE200
|
4.1
|
11.3
|
1.0
|
CA
|
B:ILE200
|
4.1
|
14.1
|
1.0
|
N
|
A:ILE200
|
4.4
|
11.8
|
1.0
|
N
|
B:ILE200
|
4.4
|
13.9
|
1.0
|
N
|
B:ILE94
|
4.4
|
13.7
|
1.0
|
N
|
A:ILE94
|
4.4
|
18.6
|
1.0
|
N
|
B:GLY201
|
4.5
|
17.7
|
1.0
|
N
|
A:GLY201
|
4.5
|
13.0
|
1.0
|
N
|
A:GLY95
|
4.5
|
20.1
|
1.0
|
N
|
B:GLY95
|
4.5
|
14.4
|
1.0
|
O
|
B:GLY201
|
4.8
|
22.8
|
1.0
|
O
|
A:GLY201
|
4.8
|
18.2
|
1.0
|
O
|
A:GLY95
|
4.8
|
24.9
|
1.0
|
O
|
B:GLY95
|
4.8
|
20.1
|
1.0
|
CA
|
B:GLY201
|
4.9
|
18.2
|
1.0
|
CA
|
A:GLY201
|
4.9
|
13.3
|
1.0
|
CA
|
A:GLY95
|
5.0
|
20.4
|
1.0
|
CA
|
B:GLY95
|
5.0
|
14.8
|
1.0
|
|
Potassium binding site 3 out
of 8 in 6rv4
Go back to
Potassium Binding Sites List in 6rv4
Potassium binding site 3 out
of 8 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237
Mono view
Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 3 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:K304
b:20.9
occ:1.00
|
OG1
|
B:THR93
|
2.8
|
15.4
|
1.0
|
OG1
|
A:THR93
|
2.8
|
28.4
|
1.0
|
O
|
A:THR199
|
2.8
|
15.8
|
1.0
|
OG1
|
A:THR199
|
2.8
|
22.0
|
1.0
|
O
|
A:THR93
|
2.9
|
23.1
|
1.0
|
O
|
B:THR93
|
2.9
|
17.6
|
1.0
|
O
|
B:THR199
|
2.9
|
14.8
|
1.0
|
OG1
|
B:THR199
|
3.0
|
16.6
|
1.0
|
CB
|
B:THR93
|
3.3
|
17.5
|
1.0
|
CB
|
A:THR93
|
3.3
|
27.6
|
1.0
|
CB
|
A:THR199
|
3.4
|
22.1
|
1.0
|
CB
|
B:THR199
|
3.5
|
17.7
|
1.0
|
K
|
A:K303
|
3.6
|
32.5
|
1.0
|
C
|
A:THR199
|
3.7
|
16.3
|
1.0
|
C
|
A:THR93
|
3.7
|
23.3
|
1.0
|
C
|
B:THR93
|
3.7
|
17.8
|
1.0
|
C
|
B:THR199
|
3.8
|
16.1
|
1.0
|
C2
|
A:KKZ307
|
3.9
|
45.5
|
1.0
|
CA
|
B:THR93
|
4.1
|
14.2
|
1.0
|
CA
|
A:THR93
|
4.2
|
20.5
|
1.0
|
CA
|
A:THR199
|
4.2
|
13.7
|
1.0
|
CA
|
B:THR199
|
4.3
|
11.7
|
1.0
|
CG2
|
B:THR93
|
4.4
|
14.5
|
1.0
|
N1
|
A:KKZ307
|
4.5
|
45.2
|
1.0
|
CG2
|
A:THR93
|
4.5
|
26.1
|
1.0
|
CG2
|
A:THR199
|
4.6
|
20.7
|
1.0
|
CG2
|
B:THR199
|
4.7
|
14.7
|
1.0
|
N
|
A:ILE200
|
4.8
|
11.8
|
1.0
|
N
|
A:ILE94
|
4.8
|
18.6
|
1.0
|
N
|
B:ILE94
|
4.8
|
13.7
|
1.0
|
N
|
B:ILE200
|
4.9
|
13.9
|
1.0
|
O
|
A:THR92
|
5.0
|
25.5
|
1.0
|
O
|
A:THR198
|
5.0
|
17.7
|
1.0
|
|
Potassium binding site 4 out
of 8 in 6rv4
Go back to
Potassium Binding Sites List in 6rv4
Potassium binding site 4 out
of 8 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237
Mono view
Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 4 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:K309
b:19.9
occ:1.00
|
O
|
B:GLY201
|
2.7
|
22.8
|
1.0
|
O
|
B:PHE202
|
2.8
|
27.7
|
1.0
|
O
|
A:GLY201
|
2.8
|
18.2
|
1.0
|
O
|
A:GLY95
|
2.8
|
24.9
|
1.0
|
O
|
A:TYR96
|
2.8
|
29.4
|
1.0
|
O
|
B:GLY95
|
2.8
|
20.1
|
1.0
|
O
|
B:TYR96
|
2.9
|
22.1
|
1.0
|
O
|
A:PHE202
|
2.9
|
21.2
|
1.0
|
K
|
A:K302
|
3.0
|
49.5
|
1.0
|
C
|
A:TYR96
|
3.4
|
29.6
|
1.0
|
C
|
B:TYR96
|
3.4
|
22.3
|
1.0
|
C
|
B:PHE202
|
3.4
|
27.4
|
1.0
|
C
|
A:PHE202
|
3.6
|
21.1
|
1.0
|
C
|
B:GLY201
|
3.8
|
23.5
|
1.0
|
CA
|
B:TYR96
|
3.8
|
17.3
|
1.0
|
CA
|
A:TYR96
|
3.8
|
22.6
|
1.0
|
C
|
A:GLY95
|
3.9
|
25.3
|
1.0
|
CA
|
B:PHE202
|
3.9
|
21.8
|
1.0
|
C
|
B:GLY95
|
3.9
|
20.3
|
1.0
|
C
|
A:GLY201
|
3.9
|
18.5
|
1.0
|
CA
|
A:PHE202
|
4.0
|
16.1
|
1.0
|
N
|
A:GLY97
|
4.2
|
28.1
|
1.0
|
N
|
B:GLY97
|
4.3
|
19.8
|
1.0
|
N
|
A:TYR96
|
4.3
|
22.4
|
1.0
|
N
|
B:PHE202
|
4.3
|
21.4
|
1.0
|
N
|
B:TYR96
|
4.3
|
17.6
|
1.0
|
N
|
B:GLY203
|
4.4
|
24.6
|
1.0
|
N
|
A:PHE202
|
4.4
|
16.0
|
1.0
|
N
|
A:GLY203
|
4.5
|
18.1
|
1.0
|
CA
|
A:GLY97
|
4.7
|
28.9
|
1.0
|
CA
|
B:GLY97
|
4.8
|
20.4
|
1.0
|
CA
|
B:GLY203
|
4.8
|
24.8
|
1.0
|
O
|
B:ILE200
|
4.9
|
19.5
|
1.0
|
O
|
B:ILE94
|
4.9
|
17.6
|
1.0
|
O
|
A:ILE94
|
4.9
|
22.0
|
1.0
|
CA
|
A:GLY203
|
4.9
|
18.2
|
1.0
|
O
|
A:ILE200
|
4.9
|
17.2
|
1.0
|
|
Potassium binding site 5 out
of 8 in 6rv4
Go back to
Potassium Binding Sites List in 6rv4
Potassium binding site 5 out
of 8 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237
Mono view
Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 5 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:K302
b:0.5
occ:1.00
|
O
|
C:GLY201
|
2.6
|
30.3
|
1.0
|
O
|
C:ILE94
|
2.7
|
21.2
|
1.0
|
O
|
C:ILE200
|
2.7
|
30.0
|
1.0
|
O
|
D:GLY95
|
2.7
|
22.1
|
1.0
|
O
|
C:GLY95
|
2.7
|
24.6
|
1.0
|
O
|
D:GLY201
|
2.7
|
32.1
|
1.0
|
O
|
D:ILE94
|
2.8
|
21.6
|
1.0
|
K
|
C:K303
|
2.8
|
10.2
|
1.0
|
O
|
D:ILE200
|
2.8
|
31.7
|
1.0
|
K
|
C:K307
|
3.0
|
25.3
|
1.0
|
C
|
C:GLY201
|
3.5
|
30.6
|
1.0
|
C
|
C:GLY95
|
3.6
|
25.1
|
1.0
|
C
|
D:GLY95
|
3.6
|
22.8
|
1.0
|
C
|
D:GLY201
|
3.6
|
32.7
|
1.0
|
C
|
C:ILE200
|
3.8
|
29.9
|
1.0
|
C
|
C:ILE94
|
3.8
|
21.4
|
1.0
|
C
|
D:ILE94
|
3.9
|
21.5
|
1.0
|
C
|
D:ILE200
|
3.9
|
31.8
|
1.0
|
CA
|
C:GLY201
|
4.1
|
26.3
|
1.0
|
CA
|
C:GLY95
|
4.2
|
19.4
|
1.0
|
CA
|
D:GLY201
|
4.2
|
28.7
|
1.0
|
CA
|
D:GLY95
|
4.2
|
18.2
|
1.0
|
N
|
C:GLY201
|
4.3
|
26.3
|
1.0
|
N
|
C:GLY95
|
4.4
|
19.0
|
1.0
|
N
|
D:GLY95
|
4.5
|
18.1
|
1.0
|
N
|
C:TYR96
|
4.5
|
23.7
|
1.0
|
N
|
D:GLY201
|
4.5
|
28.8
|
1.0
|
N
|
C:PHE202
|
4.5
|
27.2
|
1.0
|
N
|
D:TYR96
|
4.5
|
20.3
|
1.0
|
N
|
D:PHE202
|
4.6
|
29.5
|
1.0
|
CA
|
C:TYR96
|
4.8
|
24.5
|
1.0
|
CA
|
D:TYR96
|
4.9
|
20.6
|
1.0
|
CA
|
C:PHE202
|
4.9
|
27.1
|
1.0
|
O
|
C:THR199
|
4.9
|
29.4
|
1.0
|
O
|
C:THR93
|
4.9
|
17.9
|
1.0
|
O
|
D:THR93
|
4.9
|
20.1
|
1.0
|
CA
|
D:PHE202
|
5.0
|
29.1
|
1.0
|
O
|
D:THR199
|
5.0
|
31.5
|
1.0
|
|
Potassium binding site 6 out
of 8 in 6rv4
Go back to
Potassium Binding Sites List in 6rv4
Potassium binding site 6 out
of 8 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237
Mono view
Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 6 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:K303
b:10.2
occ:1.00
|
O
|
C:THR93
|
2.7
|
17.9
|
1.0
|
O
|
C:THR199
|
2.7
|
29.4
|
1.0
|
O
|
C:ILE94
|
2.7
|
21.2
|
1.0
|
O
|
D:THR93
|
2.7
|
20.1
|
1.0
|
O
|
D:THR199
|
2.7
|
31.5
|
1.0
|
O
|
D:ILE94
|
2.8
|
21.6
|
1.0
|
K
|
C:K302
|
2.8
|
0.5
|
1.0
|
O
|
C:ILE200
|
2.8
|
30.0
|
1.0
|
O
|
D:ILE200
|
2.8
|
31.7
|
1.0
|
C
|
C:ILE94
|
3.5
|
21.4
|
1.0
|
C
|
C:ILE200
|
3.5
|
29.9
|
1.0
|
C
|
D:ILE94
|
3.6
|
21.5
|
1.0
|
K
|
C:K304
|
3.6
|
39.6
|
1.0
|
C
|
D:ILE200
|
3.6
|
31.8
|
1.0
|
C
|
C:THR93
|
3.8
|
18.9
|
1.0
|
C
|
C:THR199
|
3.8
|
29.4
|
1.0
|
C
|
D:THR93
|
3.9
|
20.6
|
1.0
|
C
|
D:THR199
|
3.9
|
31.6
|
1.0
|
CA
|
C:ILE94
|
4.0
|
15.8
|
1.0
|
CA
|
C:ILE200
|
4.1
|
25.4
|
1.0
|
CA
|
D:ILE200
|
4.1
|
26.8
|
1.0
|
CA
|
D:ILE94
|
4.1
|
16.6
|
1.0
|
N
|
C:ILE94
|
4.4
|
16.1
|
1.0
|
N
|
C:ILE200
|
4.4
|
25.7
|
1.0
|
N
|
D:ILE200
|
4.4
|
27.4
|
1.0
|
N
|
D:ILE94
|
4.4
|
17.0
|
1.0
|
N
|
C:GLY201
|
4.4
|
26.3
|
1.0
|
N
|
C:GLY95
|
4.5
|
19.0
|
1.0
|
N
|
D:GLY201
|
4.5
|
28.8
|
1.0
|
N
|
D:GLY95
|
4.5
|
18.1
|
1.0
|
O
|
C:GLY201
|
4.8
|
30.3
|
1.0
|
O
|
D:GLY95
|
4.8
|
22.1
|
1.0
|
O
|
D:GLY201
|
4.8
|
32.1
|
1.0
|
O
|
C:GLY95
|
4.8
|
24.6
|
1.0
|
CA
|
C:GLY201
|
4.9
|
26.3
|
1.0
|
CA
|
D:GLY201
|
4.9
|
28.7
|
1.0
|
CA
|
C:GLY95
|
4.9
|
19.4
|
1.0
|
CA
|
D:GLY95
|
5.0
|
18.2
|
1.0
|
|
Potassium binding site 7 out
of 8 in 6rv4
Go back to
Potassium Binding Sites List in 6rv4
Potassium binding site 7 out
of 8 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237
Mono view
Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 7 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:K304
b:39.6
occ:1.00
|
OG1
|
D:THR93
|
2.8
|
19.1
|
1.0
|
OG1
|
C:THR93
|
2.8
|
18.2
|
1.0
|
O
|
C:THR199
|
2.8
|
29.4
|
1.0
|
O
|
D:THR93
|
2.8
|
20.1
|
1.0
|
O
|
C:THR93
|
2.9
|
17.9
|
1.0
|
OG1
|
C:THR199
|
2.9
|
27.7
|
1.0
|
O
|
D:THR199
|
2.9
|
31.5
|
1.0
|
OG1
|
D:THR199
|
3.0
|
34.0
|
1.0
|
CB
|
D:THR93
|
3.2
|
22.4
|
1.0
|
CB
|
C:THR93
|
3.3
|
21.1
|
1.0
|
CB
|
C:THR199
|
3.4
|
30.0
|
1.0
|
CB
|
D:THR199
|
3.5
|
33.6
|
1.0
|
K
|
C:K303
|
3.6
|
10.2
|
1.0
|
C
|
D:THR93
|
3.7
|
20.6
|
1.0
|
C
|
C:THR199
|
3.7
|
29.4
|
1.0
|
C
|
C:THR93
|
3.7
|
18.9
|
1.0
|
C
|
D:THR199
|
3.8
|
31.6
|
1.0
|
C2
|
D:KKZ302
|
3.9
|
76.0
|
1.0
|
CA
|
D:THR93
|
4.1
|
17.0
|
1.0
|
CA
|
C:THR93
|
4.1
|
15.2
|
1.0
|
CA
|
C:THR199
|
4.2
|
25.1
|
1.0
|
CA
|
D:THR199
|
4.3
|
28.3
|
1.0
|
CG2
|
D:THR93
|
4.4
|
21.1
|
1.0
|
CG2
|
C:THR93
|
4.5
|
20.6
|
1.0
|
N1
|
D:KKZ302
|
4.5
|
75.0
|
1.0
|
CG2
|
C:THR199
|
4.6
|
28.5
|
1.0
|
CG2
|
D:THR199
|
4.7
|
30.6
|
1.0
|
N
|
C:ILE200
|
4.8
|
25.7
|
1.0
|
N
|
C:ILE94
|
4.8
|
16.1
|
1.0
|
N
|
D:ILE94
|
4.8
|
17.0
|
1.0
|
N
|
D:ILE200
|
4.9
|
27.4
|
1.0
|
O
|
C:THR92
|
5.0
|
19.5
|
1.0
|
|
Potassium binding site 8 out
of 8 in 6rv4
Go back to
Potassium Binding Sites List in 6rv4
Potassium binding site 8 out
of 8 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237
Mono view
Stereo pair view
|
A full contact list of Potassium with other atoms in the K binding
site number 8 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 2341237 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:K307
b:25.3
occ:1.00
|
O
|
C:GLY201
|
2.8
|
30.3
|
1.0
|
O
|
D:GLY201
|
2.8
|
32.1
|
1.0
|
O
|
D:PHE202
|
2.8
|
33.5
|
1.0
|
O
|
C:GLY95
|
2.8
|
24.6
|
1.0
|
O
|
C:TYR96
|
2.8
|
29.4
|
1.0
|
O
|
C:PHE202
|
2.8
|
32.4
|
1.0
|
O
|
D:TYR96
|
2.8
|
25.2
|
1.0
|
O
|
D:GLY95
|
2.9
|
22.1
|
1.0
|
K
|
C:K302
|
3.0
|
0.5
|
1.0
|
C
|
C:TYR96
|
3.4
|
29.8
|
1.0
|
C
|
D:TYR96
|
3.4
|
25.4
|
1.0
|
C
|
D:PHE202
|
3.5
|
33.8
|
1.0
|
C
|
C:PHE202
|
3.5
|
32.7
|
1.0
|
CA
|
C:TYR96
|
3.8
|
24.5
|
1.0
|
CA
|
D:TYR96
|
3.9
|
20.6
|
1.0
|
C
|
C:GLY95
|
3.9
|
25.1
|
1.0
|
C
|
C:GLY201
|
3.9
|
30.6
|
1.0
|
C
|
D:GLY201
|
3.9
|
32.7
|
1.0
|
C
|
D:GLY95
|
3.9
|
22.8
|
1.0
|
CA
|
D:PHE202
|
4.0
|
29.1
|
1.0
|
CA
|
C:PHE202
|
4.0
|
27.1
|
1.0
|
N
|
C:GLY97
|
4.2
|
27.5
|
1.0
|
N
|
D:GLY97
|
4.3
|
22.5
|
1.0
|
N
|
C:TYR96
|
4.3
|
23.7
|
1.0
|
N
|
D:TYR96
|
4.3
|
20.3
|
1.0
|
N
|
D:PHE202
|
4.4
|
29.5
|
1.0
|
N
|
C:PHE202
|
4.4
|
27.2
|
1.0
|
N
|
D:GLY203
|
4.4
|
30.8
|
1.0
|
N
|
C:GLY203
|
4.4
|
30.2
|
1.0
|
CA
|
C:GLY97
|
4.7
|
27.9
|
1.0
|
CA
|
D:GLY97
|
4.7
|
22.8
|
1.0
|
CA
|
D:GLY203
|
4.9
|
31.1
|
1.0
|
CA
|
C:GLY203
|
4.9
|
30.5
|
1.0
|
O
|
C:ILE94
|
4.9
|
21.2
|
1.0
|
O
|
D:ILE200
|
4.9
|
31.7
|
1.0
|
O
|
C:ILE200
|
4.9
|
30.0
|
1.0
|
O
|
D:ILE94
|
5.0
|
21.6
|
1.0
|
|
Reference:
K.E.J.Rodstrom,
A.K.Kiper,
W.Zhang,
S.Rinne,
A.C.W.Pike,
M.Goldstein,
L.Conrad,
M.Delbeck,
M.Hahn,
H.Meier,
M.Platzk,
A.Quigley,
D.Speedman,
L.Shrestha,
S.M.M.Mukhopadhyay,
N.A.Burgess-Brown,
S.J.Tucker,
T.Mueller,
N.Decher,
E.P.Carpenter.
A Unique Lower X-Gate in Task Channels Sequesters Inhibitors Within the Vestibule To Be Published.
Page generated: Mon Aug 12 17:30:53 2024
|