Atomistry » Potassium » PDB 6qml-6rv4 » 6rv3
Atomistry »
  Potassium »
    PDB 6qml-6rv4 »
      6rv3 »

Potassium in PDB 6rv3: Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 1000493

Protein crystallography data

The structure of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 1000493, PDB code: 6rv3 was solved by K.E.J.Rodstrom, A.C.W.Pike, W.Zhang, A.Quigley, D.Speedman, S.M.M.Mukhopadhyay, L.Shrestha, R.Chalk, S.Venkaya, S.R.Bushell, A.Tessitore, N.Burgess-Brown, C.H.Arrowsmith, A.M.Edwards, C.Bountra, E.P.Carpenter, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 41.31 / 2.90
Space group P 2 21 21
Cell size a, b, c (Å), α, β, γ (°) 45.070, 204.500, 239.320, 90.00, 90.00, 90.00
R / Rfree (%) 23.5 / 24.2

Other elements in 6rv3:

The structure of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 1000493 also contains other interesting chemical elements:

Fluorine (F) 4 atoms
Bromine (Br) 4 atoms

Potassium Binding Sites:

The binding sites of Potassium atom in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 1000493 (pdb code 6rv3). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 8 binding sites of Potassium where determined in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 1000493, PDB code: 6rv3:
Jump to Potassium binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Potassium binding site 1 out of 8 in 6rv3

Go back to Potassium Binding Sites List in 6rv3
Potassium binding site 1 out of 8 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 1000493


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 1000493 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K301

b:37.9
occ:1.00
 O A:GLY201 2.6 15.5 1.0
O A:ILE200 2.7 15.0 1.0
O A:ILE94 2.7 23.1 1.0
O B:GLY95 2.7 17.3 1.0
O B:GLY201 2.8 21.9 1.0
K A:K303 2.8 19.7 1.0
O A:GLY95 2.8 26.4 1.0
O B:ILE94 2.8 15.8 1.0
O B:ILE200 2.8 21.5 1.0
K A:K309 3.1 28.0 1.0
C A:GLY201 3.5 16.4 1.0
C A:GLY95 3.6 25.8 1.0
C B:GLY95 3.6 17.0 1.0
C B:GLY201 3.6 21.7 1.0
C A:ILE200 3.8 14.9 1.0
C A:ILE94 3.9 23.0 1.0
C B:ILE94 3.9 15.5 1.0
C B:ILE200 3.9 21.1 1.0
CA A:GLY201 4.0 11.2 1.0
CA B:GLY201 4.1 16.9 1.0
CA B:GLY95 4.1 11.9 1.0
CA A:GLY95 4.2 20.3 1.0
N A:GLY201 4.3 11.1 1.0
N A:GLY95 4.4 20.3 1.0
N B:GLY95 4.4 11.7 1.0
N B:GLY201 4.4 17.0 1.0
N A:PHE202 4.4 14.3 1.0
N A:TYR96 4.5 21.9 1.0
N B:TYR96 4.5 13.3 1.0
N B:PHE202 4.6 17.8 1.0
CA A:TYR96 4.8 21.1 1.0
O A:THR199 4.8 18.0 1.0
O A:THR93 4.9 24.6 1.0
CA A:PHE202 4.9 14.5 1.0
O B:THR93 4.9 17.1 1.0
CA B:TYR96 4.9 13.8 1.0
O B:THR199 4.9 18.0 1.0
CA B:PHE202 5.0 16.8 1.0

Potassium binding site 2 out of 8 in 6rv3

Go back to Potassium Binding Sites List in 6rv3
Potassium binding site 2 out of 8 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 1000493


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 1000493 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K303

b:19.7
occ:1.00
 O A:THR199 2.6 18.0 1.0
O B:THR93 2.7 17.1 1.0
O A:THR93 2.7 24.6 1.0
O B:THR199 2.7 18.0 1.0
K A:K301 2.8 37.9 1.0
O A:ILE200 2.8 15.0 1.0
O A:ILE94 2.8 23.1 1.0
O B:ILE94 2.8 15.8 1.0
O B:ILE200 2.9 21.5 1.0
K A:K304 3.5 23.1 1.0
C A:ILE200 3.5 14.9 1.0
C A:ILE94 3.5 23.0 1.0
C B:ILE94 3.6 15.5 1.0
C B:ILE200 3.6 21.1 1.0
C A:THR199 3.7 18.0 1.0
C A:THR93 3.8 24.6 1.0
C B:THR93 3.8 17.5 1.0
C B:THR199 3.9 19.5 1.0
CA A:ILE200 4.0 9.9 1.0
CA A:ILE94 4.0 16.8 1.0
CA B:ILE94 4.1 10.3 1.0
CA B:ILE200 4.2 16.5 1.0
N A:ILE200 4.3 11.3 1.0
N A:GLY201 4.4 11.1 1.0
N A:ILE94 4.4 18.1 1.0
N B:ILE94 4.4 11.7 1.0
N B:GLY95 4.4 11.7 1.0
N A:GLY95 4.5 20.3 1.0
N B:ILE200 4.5 16.6 1.0
N B:GLY201 4.5 17.0 1.0
O A:GLY201 4.8 15.5 1.0
CA A:GLY201 4.8 11.2 1.0
O B:GLY95 4.8 17.3 1.0
O A:GLY95 4.8 26.4 1.0
O B:GLY201 4.8 21.9 1.0
CA B:GLY95 4.9 11.9 1.0
CA B:GLY201 4.9 16.9 1.0
CA A:GLY95 4.9 20.3 1.0
CA A:THR199 4.9 16.4 1.0

Potassium binding site 3 out of 8 in 6rv3

Go back to Potassium Binding Sites List in 6rv3
Potassium binding site 3 out of 8 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 1000493


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 1000493 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K304

b:23.1
occ:1.00
 OG1 B:THR93 2.7 21.7 1.0
O A:THR199 2.8 18.0 1.0
OG1 A:THR93 2.8 24.0 1.0
O B:THR93 2.8 17.1 1.0
O B:THR199 2.8 18.0 1.0
O A:THR93 2.9 24.6 1.0
OG1 A:THR199 2.9 17.3 1.0
OG1 B:THR199 3.0 24.2 1.0
CB B:THR93 3.3 21.0 1.0
CB A:THR93 3.3 27.5 1.0
CB A:THR199 3.4 21.4 1.0
K A:K303 3.5 19.7 1.0
CB B:THR199 3.5 24.1 1.0
C A:THR199 3.7 18.0 1.0
C B:THR93 3.7 17.5 1.0
C A:THR93 3.7 24.6 1.0
C B:THR199 3.8 19.5 1.0
CA B:THR93 4.1 16.6 1.0
C2 A:KKQ300 4.1 48.7 0.5
CA A:THR93 4.1 23.8 1.0
CA A:THR199 4.1 16.4 1.0
C2 A:KKQ300 4.2 53.0 0.5
CA B:THR199 4.3 16.1 1.0
CG2 B:THR93 4.5 16.6 1.0
CG2 A:THR93 4.6 26.6 1.0
CG2 A:THR199 4.7 20.2 1.0
N A:ILE200 4.7 11.3 1.0
N B:ILE94 4.7 11.7 1.0
N A:ILE94 4.7 18.1 1.0
N1 A:KKQ300 4.7 48.6 0.5
CG2 B:THR199 4.8 21.9 1.0
N B:ILE200 4.8 16.6 1.0
N1 A:KKQ300 4.9 52.6 0.5
O A:THR92 5.0 29.0 1.0
O A:THR198 5.0 21.7 1.0
O B:THR92 5.0 21.7 1.0

Potassium binding site 4 out of 8 in 6rv3

Go back to Potassium Binding Sites List in 6rv3
Potassium binding site 4 out of 8 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 1000493


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 1000493 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K309

b:28.0
occ:1.00
 O A:TYR96 2.7 27.2 1.0
O B:TYR96 2.8 20.8 1.0
O B:GLY201 2.8 21.9 1.0
O A:GLY201 2.8 15.5 1.0
O B:PHE202 2.8 25.5 1.0
O A:PHE202 2.9 21.1 1.0
O A:GLY95 2.9 26.4 1.0
O B:GLY95 2.9 17.3 1.0
K A:K301 3.1 37.9 1.0
C A:TYR96 3.4 27.0 1.0
C B:TYR96 3.4 21.1 1.0
C B:PHE202 3.5 23.9 1.0
C A:PHE202 3.5 19.6 1.0
CA A:TYR96 3.9 21.1 1.0
C B:GLY201 3.9 21.7 1.0
C A:GLY201 3.9 16.4 1.0
CA B:TYR96 3.9 13.8 1.0
CA B:PHE202 3.9 16.8 1.0
C A:GLY95 4.0 25.8 1.0
CA A:PHE202 4.0 14.5 1.0
C B:GLY95 4.0 17.0 1.0
N A:GLY97 4.2 24.7 1.0
N B:GLY97 4.3 20.1 1.0
N B:GLY203 4.4 20.8 1.0
N A:GLY203 4.4 15.4 1.0
N B:PHE202 4.4 17.8 1.0
N A:TYR96 4.4 21.9 1.0
N A:PHE202 4.4 14.3 1.0
N B:TYR96 4.4 13.3 1.0
CA A:GLY97 4.7 25.4 1.0
CA B:GLY97 4.7 21.0 1.0
CA B:GLY203 4.8 21.1 1.0
CA A:GLY203 4.8 15.8 1.0

Potassium binding site 5 out of 8 in 6rv3

Go back to Potassium Binding Sites List in 6rv3
Potassium binding site 5 out of 8 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 1000493


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 5 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 1000493 within 5.0Å range:
probe atom residue distance (Å) B Occ
C:K301

b:20.2
occ:1.00
 O C:TYR96 2.7 27.1 1.0
O D:TYR96 2.8 27.4 1.0
O C:GLY201 2.8 18.0 1.0
O D:GLY201 2.8 21.9 1.0
O D:PHE202 2.8 20.8 1.0
O C:PHE202 2.9 18.5 1.0
O C:GLY95 2.9 21.8 1.0
O D:GLY95 2.9 24.1 1.0
K C:K302 3.1 76.2 1.0
C C:TYR96 3.4 27.0 1.0
C D:TYR96 3.4 27.2 1.0
C D:PHE202 3.5 20.8 1.0
C C:PHE202 3.5 19.1 1.0
CA C:TYR96 3.9 21.2 1.0
C C:GLY201 3.9 18.0 1.0
C D:GLY201 3.9 22.4 1.0
CA D:PHE202 3.9 16.9 1.0
CA D:TYR96 4.0 22.1 1.0
C C:GLY95 4.0 22.2 1.0
CA C:PHE202 4.0 12.9 1.0
C D:GLY95 4.0 24.7 1.0
N C:GLY97 4.2 24.6 1.0
N D:GLY97 4.3 24.0 1.0
N C:GLY203 4.4 17.6 1.0
N C:TYR96 4.4 20.5 1.0
N D:GLY203 4.4 17.1 1.0
N C:PHE202 4.4 13.6 1.0
N D:PHE202 4.4 18.1 1.0
N D:TYR96 4.5 22.0 1.0
CA C:GLY97 4.7 25.5 1.0
CA D:GLY97 4.7 24.4 1.0
CA C:GLY203 4.8 18.2 1.0
CA D:GLY203 4.8 17.2 1.0

Potassium binding site 6 out of 8 in 6rv3

Go back to Potassium Binding Sites List in 6rv3
Potassium binding site 6 out of 8 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 1000493


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 6 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 1000493 within 5.0Å range:
probe atom residue distance (Å) B Occ
C:K302

b:76.2
occ:1.00
 O C:GLY201 2.6 18.0 1.0
O C:ILE200 2.7 19.4 1.0
O D:GLY95 2.7 24.1 1.0
O C:ILE94 2.8 21.6 1.0
K C:K303 2.8 26.5 1.0
O C:GLY95 2.8 21.8 1.0
O D:GLY201 2.8 21.9 1.0
O D:ILE94 2.8 23.6 1.0
O D:ILE200 2.8 24.8 1.0
K C:K301 3.1 20.2 1.0
C C:GLY201 3.5 18.0 1.0
C D:GLY95 3.6 24.7 1.0
C C:GLY95 3.6 22.2 1.0
C D:GLY201 3.6 22.4 1.0
C C:ILE200 3.8 18.7 1.0
C C:ILE94 3.9 21.3 1.0
C D:ILE94 3.9 23.1 1.0
C D:ILE200 3.9 24.0 1.0
CA C:GLY201 4.0 13.8 1.0
CA D:GLY95 4.1 20.4 1.0
CA D:GLY201 4.1 19.9 1.0
CA C:GLY95 4.2 17.1 1.0
N C:GLY201 4.3 13.8 1.0
N C:GLY95 4.4 17.4 1.0
N C:PHE202 4.4 13.6 1.0
N D:GLY95 4.4 20.3 1.0
N D:GLY201 4.5 20.5 1.0
N C:TYR96 4.5 20.5 1.0
N D:TYR96 4.5 22.0 1.0
N D:PHE202 4.6 18.1 1.0
CA C:TYR96 4.8 21.2 1.0
CA C:PHE202 4.9 12.9 1.0
O C:THR199 4.9 18.0 1.0
O D:THR93 4.9 19.4 1.0
O C:THR93 4.9 19.1 1.0
CA D:TYR96 4.9 22.1 1.0
O D:THR199 4.9 23.3 1.0
CA D:PHE202 5.0 16.9 1.0

Potassium binding site 7 out of 8 in 6rv3

Go back to Potassium Binding Sites List in 6rv3
Potassium binding site 7 out of 8 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 1000493


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 7 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 1000493 within 5.0Å range:
probe atom residue distance (Å) B Occ
C:K303

b:26.5
occ:1.00
 O C:THR199 2.6 18.0 1.0
O C:THR93 2.7 19.1 1.0
O D:THR93 2.7 19.4 1.0
O C:ILE200 2.7 19.4 1.0
K C:K302 2.8 76.2 1.0
O C:ILE94 2.8 21.6 1.0
O D:THR199 2.8 23.3 1.0
O D:ILE200 2.9 24.8 1.0
O D:ILE94 2.9 23.6 1.0
K C:K304 3.5 38.0 1.0
C C:ILE200 3.5 18.7 1.0
C C:ILE94 3.5 21.3 1.0
C D:ILE94 3.6 23.1 1.0
C D:ILE200 3.7 24.0 1.0
C C:THR199 3.7 18.8 1.0
C C:THR93 3.8 19.6 1.0
C D:THR93 3.9 19.3 1.0
C D:THR199 3.9 24.4 1.0
CA C:ILE200 4.0 13.5 1.0
CA C:ILE94 4.0 15.8 1.0
CA D:ILE94 4.2 17.2 1.0
CA D:ILE200 4.2 18.3 1.0
N C:ILE200 4.3 13.9 1.0
N C:GLY201 4.3 13.8 1.0
N C:ILE94 4.4 16.3 1.0
N C:GLY95 4.4 17.4 1.0
N D:ILE94 4.5 16.4 1.0
N D:GLY95 4.5 20.3 1.0
N D:ILE200 4.5 19.1 1.0
N D:GLY201 4.6 20.5 1.0
CA C:GLY201 4.7 13.8 1.0
O C:GLY201 4.8 18.0 1.0
O D:GLY95 4.8 24.1 1.0
O C:GLY95 4.8 21.8 1.0
O D:GLY201 4.9 21.9 1.0
CA C:GLY95 4.9 17.1 1.0
CA D:GLY95 4.9 20.4 1.0
CA C:THR199 4.9 16.1 1.0
CA D:GLY201 5.0 19.9 1.0

Potassium binding site 8 out of 8 in 6rv3

Go back to Potassium Binding Sites List in 6rv3
Potassium binding site 8 out of 8 in the Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 1000493


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 8 of Crystal Structure of the Human Two Pore Domain Potassium Ion Channel Task-1 (K2P3.1) in A Closed Conformation with A Bound Inhibitor Bay 1000493 within 5.0Å range:
probe atom residue distance (Å) B Occ
C:K304

b:38.0
occ:1.00
 OG1 C:THR93 2.7 19.3 1.0
O C:THR199 2.8 18.0 1.0
OG1 D:THR93 2.8 12.7 1.0
O C:THR93 2.8 19.1 1.0
O D:THR199 2.8 23.3 1.0
O D:THR93 2.9 19.4 1.0
OG1 C:THR199 3.0 23.3 1.0
OG1 D:THR199 3.0 31.0 1.0
CB C:THR93 3.3 22.8 1.0
CB D:THR93 3.3 20.8 1.0
CB C:THR199 3.4 23.3 1.0
K C:K303 3.5 26.5 1.0
CB D:THR199 3.5 29.8 1.0
C C:THR93 3.6 19.6 1.0
C C:THR199 3.7 18.8 1.0
C D:THR93 3.7 19.3 1.0
C D:THR199 3.7 24.4 1.0
CA C:THR93 4.1 16.2 1.0
C2 C:KKQ306 4.1 69.9 0.5
C2 C:KKQ306 4.2 59.2 0.5
CA D:THR93 4.2 15.9 1.0
CA C:THR199 4.2 16.1 1.0
CA D:THR199 4.3 23.2 1.0
CG2 C:THR93 4.5 23.0 1.0
CG2 D:THR93 4.5 21.8 1.0
CG2 C:THR199 4.7 20.1 1.0
N C:ILE94 4.7 16.3 1.0
N1 C:KKQ306 4.7 68.8 0.5
CG2 D:THR199 4.8 26.7 1.0
N C:ILE200 4.8 13.9 1.0
N D:ILE94 4.8 16.4 1.0
N D:ILE200 4.8 19.1 1.0
N1 C:KKQ306 4.9 58.3 0.5
O C:THR92 5.0 22.8 1.0

Reference:

K.E.J.Rodstrom, A.K.Kiper, W.Zhang, S.Rinne, A.C.W.Pike, M.Goldstein, L.Conrad, M.Delbeck, M.Hahn, H.Meier, M.Platzk, A.Quigley, D.Speedman, L.Shrestha, S.M.M.Mukhopadhyay, N.A.Burgess-Brown, S.J.Tucker, T.Mueller, N.Decher, E.P.Carpenter. A Unique Lower X-Gate in Task Channels Sequesters Inhibitors Within the Vestibule To Be Published.
Page generated: Mon Aug 12 17:30:52 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy