Potassium in PDB 6hfc: Influenza A Virus N9 Neuraminidase Native (Tern).

All present enzymatic activity of Influenza A Virus N9 Neuraminidase Native (Tern).:
3.2.1.18;

The structure of Influenza A Virus N9 Neuraminidase Native (Tern)., PDB code: 6hfc was solved by M.T.Salinger, J.R.Hobbs, J.W.Murray, W.G.Laver, P.Kuhn, E.F.Garman, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.89 / 1.29
Space group	I 4 3 2
Cell size a, b, c (Å), α, β, γ (°)	180.000, 180.000, 180.000, 90.00, 90.00, 90.00
R / Rfree (%)	14.1 / 16.4

The structure of Influenza A Virus N9 Neuraminidase Native (Tern). also contains other interesting chemical elements:

Calcium

(Ca)

2 atoms

The binding sites of Potassium atom in the Influenza A Virus N9 Neuraminidase Native (Tern). (pdb code 6hfc). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 3 binding sites of Potassium where determined in the Influenza A Virus N9 Neuraminidase Native (Tern)., PDB code: 6hfc:
Jump to Potassium binding site number: 1; 2; 3;

Potassium binding site 1 out of 3 in the Influenza A Virus N9 Neuraminidase Native (Tern).


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Influenza A Virus N9 Neuraminidase Native (Tern). within 5.0Å range: probe atom residue distance (Å) B Occ A:K524 b:32.6 occ:0.80 O5 A:NAG502 2.7 19.6 1.0 O3 A:NAG501 2.8 21.6 1.0 O A:HOH830 3.0 34.4 1.0 O A:HOH1031 3.0 55.9 1.0 O6 A:NAG502 3.1 29.7 1.0 O4 A:NAG501 3.4 18.3 1.0 O6 A:MAN508 3.5 31.8 1.0 C1 A:NAG502 3.6 18.1 1.0 O A:HOH887 3.7 48.3 1.0 C3 A:NAG501 3.7 20.1 1.0 C5 A:NAG502 3.8 20.2 1.0 C6 A:NAG502 3.9 24.6 1.0 C6 A:MAN508 4.0 35.3 1.0 C4 A:NAG501 4.1 18.9 1.0 C2 A:NAG502 4.1 17.7 1.0 O A:HOH632 4.2 39.2 1.0 C4 A:NAG502 4.4 18.2 1.0 O A:HOH997 4.5 42.2 1.0 O A:HOH1010 4.8 55.4 1.0 O7 A:NAG502 4.8 24.6 1.0 C3 A:NAG502 4.9 17.0 1.0

Potassium binding site 2 out of 3 in the Influenza A Virus N9 Neuraminidase Native (Tern).


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Influenza A Virus N9 Neuraminidase Native (Tern). within 5.0Å range: probe atom residue distance (Å) B Occ A:K525 b:52.4 occ:0.50 K A:K525 0.0 52.4 0.5 K A:K525 2.5 45.8 0.5 OE1 A:GLU278 2.7 34.4 0.8 OE2 A:GLU278 3.1 30.5 0.8 CD A:GLU278 3.2 34.9 0.8 O A:HOH1090 3.9 36.9 1.0 NH1 A:ARG294 3.9 19.0 1.0 OD1 A:ASN296 4.0 24.2 1.0 CG A:ASN296 4.0 19.3 1.0 CB A:ALA248 4.0 23.9 1.0 OE2 A:GLU278 4.0 12.8 0.2 ND2 A:ASN296 4.1 16.8 1.0 CD A:GLU278 4.1 13.8 0.2 CZ A:ARG294 4.2 18.3 1.0 OE1 A:GLU278 4.4 12.8 0.2 O A:HOH610 4.4 35.7 1.0 CG A:GLU278 4.5 13.8 0.2 CB A:ASN296 4.5 18.0 1.0 NE A:ARG294 4.6 17.6 1.0 CG A:GLU278 4.7 29.6 0.8 O A:HOH993 4.7 47.6 1.0 O2 A:GOL522 4.7 56.2 1.0 NH2 A:ARG294 4.8 18.0 1.0 NE A:ARG226 4.9 18.8 1.0

Potassium binding site 3 out of 3 in the Influenza A Virus N9 Neuraminidase Native (Tern).


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Influenza A Virus N9 Neuraminidase Native (Tern). within 5.0Å range: probe atom residue distance (Å) B Occ A:K525 b:45.8 occ:0.50 K A:K525 0.0 45.8 0.5 K A:K525 2.5 52.4 0.5 OE2 A:GLU279 3.2 22.6 1.0 O2 A:GOL522 3.4 56.2 1.0 O A:HOH610 3.5 35.7 1.0 NH2 A:ARG294 3.7 18.0 1.0 OE1 A:GLU278 3.7 34.4 0.8 CZ A:ARG294 3.8 18.3 1.0 OH A:TYR406 3.9 19.2 1.0 NH1 A:ARG294 3.9 19.0 1.0 O A:HOH1005 4.0 38.9 1.0 CD A:GLU279 4.0 20.0 1.0 OE1 A:GLU279 4.4 19.8 1.0 C2 A:GOL522 4.5 47.3 1.0 CD A:GLU278 4.5 34.9 0.8 C1 A:GOL522 4.5 56.1 1.0 NE A:ARG294 4.6 17.6 1.0 O1 A:GOL522 4.8 55.1 1.0 O A:HOH850 4.8 33.9 1.0 OE2 A:GLU278 4.8 30.5 0.8 CG A:GLU279 5.0 18.0 1.0 OE1 A:GLU278 5.0 12.8 0.2

M.T.Salinger, J.R.Hobbs, J.W.Murray, W.G.Laver, P.Kuhn, E.F.Garman. High Resolution Structures of Viral Neuraminidase with Drugs Bound in the Active Site. (in Preparation) To Be Published.