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Potassium in PDB 6evv: X-Ray Structure of the Complex Between Human Alpha Thrombin and NU172, A Duplex/Quadruplex 26-Mer Dna Aptamer, in the Presence of Potassium Ions.

Enzymatic activity of X-Ray Structure of the Complex Between Human Alpha Thrombin and NU172, A Duplex/Quadruplex 26-Mer Dna Aptamer, in the Presence of Potassium Ions.

All present enzymatic activity of X-Ray Structure of the Complex Between Human Alpha Thrombin and NU172, A Duplex/Quadruplex 26-Mer Dna Aptamer, in the Presence of Potassium Ions.:
3.4.21.5;

Protein crystallography data

The structure of X-Ray Structure of the Complex Between Human Alpha Thrombin and NU172, A Duplex/Quadruplex 26-Mer Dna Aptamer, in the Presence of Potassium Ions., PDB code: 6evv was solved by R.Troisi, I.Russo Krauss, F.Sica, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 104.02 / 2.50
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 67.875, 113.595, 208.034, 90.00, 90.00, 90.00
R / Rfree (%) 16.9 / 20.5

Other elements in 6evv:

The structure of X-Ray Structure of the Complex Between Human Alpha Thrombin and NU172, A Duplex/Quadruplex 26-Mer Dna Aptamer, in the Presence of Potassium Ions. also contains other interesting chemical elements:

Sodium (Na) 1 atom

Potassium Binding Sites:

The binding sites of Potassium atom in the X-Ray Structure of the Complex Between Human Alpha Thrombin and NU172, A Duplex/Quadruplex 26-Mer Dna Aptamer, in the Presence of Potassium Ions. (pdb code 6evv). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total only one binding site of Potassium was determined in the X-Ray Structure of the Complex Between Human Alpha Thrombin and NU172, A Duplex/Quadruplex 26-Mer Dna Aptamer, in the Presence of Potassium Ions., PDB code: 6evv:

Potassium binding site 1 out of 1 in 6evv

Go back to Potassium Binding Sites List in 6evv
Potassium binding site 1 out of 1 in the X-Ray Structure of the Complex Between Human Alpha Thrombin and NU172, A Duplex/Quadruplex 26-Mer Dna Aptamer, in the Presence of Potassium Ions.


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of X-Ray Structure of the Complex Between Human Alpha Thrombin and NU172, A Duplex/Quadruplex 26-Mer Dna Aptamer, in the Presence of Potassium Ions. within 5.0Å range:
probe atom residue distance (Å) B Occ
E:K101

b:65.4
occ:1.00
O6 E:DG16 2.6 51.4 1.0
O6 E:DG12 2.6 51.6 1.0
O6 E:DG7 2.7 64.8 1.0
O6 E:DG21 2.7 77.0 1.0
O6 E:DG11 2.8 58.4 1.0
O6 E:DG20 2.8 54.1 1.0
O6 E:DG8 3.0 66.0 1.0
O6 E:DG17 3.0 58.8 1.0
C6 E:DG16 3.4 57.8 1.0
C6 E:DG12 3.5 50.0 1.0
C6 E:DG7 3.5 59.2 1.0
C6 E:DG20 3.6 81.1 1.0
C6 E:DG11 3.6 47.4 1.0
N1 E:DG16 3.6 57.6 1.0
C6 E:DG21 3.7 89.9 1.0
N1 E:DG12 3.7 41.4 1.0
N1 E:DG7 3.7 53.9 1.0
C6 E:DG17 3.8 58.2 1.0
N1 E:DG20 3.9 63.4 1.0
C6 E:DG8 3.9 59.3 1.0
N1 E:DG21 3.9 75.9 1.0
O E:HOH201 4.0 64.3 1.0
N1 E:DG11 4.1 50.2 1.0
N1 E:DG17 4.1 50.2 1.0
N1 E:DG8 4.2 53.7 1.0
N1 E:DA6 4.4 54.6 1.0
N6 E:DA6 4.4 68.7 1.0
C6 E:DA6 4.5 62.5 1.0
C5 E:DG16 4.7 42.7 1.0
C5 E:DG11 4.8 41.3 1.0
C5 E:DG20 4.8 62.4 1.0
C5 E:DG7 4.9 53.4 1.0
C5 E:DG12 4.9 41.3 1.0
O4 E:DT22 4.9 0.2 1.0
C2 E:DG16 4.9 62.4 1.0

Reference:

R.Troisi, V.Napolitano, V.Spiridonova, I.Russo Krauss, F.Sica. Several Structural Motifs Cooperate in Determining the Highly Effective Anti-Thrombin Activity of NU172 Aptamer. Nucleic Acids Res. V. 46 12177 2018.
ISSN: ESSN 1362-4962
PubMed: 30357392
DOI: 10.1093/NAR/GKY990
Page generated: Mon Dec 14 00:36:58 2020

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