Potassium in PDB 6dxz: Rabbit N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) in Complex with Non-Covalent Benzothiazole-Piperazine Inhibitor ARN19702, in Presence of Triton X-100

Enzymatic activity of Rabbit N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) in Complex with Non-Covalent Benzothiazole-Piperazine Inhibitor ARN19702, in Presence of Triton X-100

All present enzymatic activity of Rabbit N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) in Complex with Non-Covalent Benzothiazole-Piperazine Inhibitor ARN19702, in Presence of Triton X-100:
3.5.1.60;

Protein crystallography data

The structure of Rabbit N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) in Complex with Non-Covalent Benzothiazole-Piperazine Inhibitor ARN19702, in Presence of Triton X-100, PDB code: 6dxz was solved by A.Gorelik, A.Gebai, K.Illes, D.Piomelli, B.Nagar, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 45.94 / 2.70
Space group P 43 3 2
Cell size a, b, c (Å), α, β, γ (°) 159.143, 159.143, 159.143, 90.00, 90.00, 90.00
R / Rfree (%) 18.2 / 22.2

Other elements in 6dxz:

The structure of Rabbit N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) in Complex with Non-Covalent Benzothiazole-Piperazine Inhibitor ARN19702, in Presence of Triton X-100 also contains other interesting chemical elements:

Fluorine (F) 1 atom

Potassium Binding Sites:

The binding sites of Potassium atom in the Rabbit N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) in Complex with Non-Covalent Benzothiazole-Piperazine Inhibitor ARN19702, in Presence of Triton X-100 (pdb code 6dxz). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total only one binding site of Potassium was determined in the Rabbit N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) in Complex with Non-Covalent Benzothiazole-Piperazine Inhibitor ARN19702, in Presence of Triton X-100, PDB code: 6dxz:

Potassium binding site 1 out of 1 in 6dxz

Go back to Potassium Binding Sites List in 6dxz
Potassium binding site 1 out of 1 in the Rabbit N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) in Complex with Non-Covalent Benzothiazole-Piperazine Inhibitor ARN19702, in Presence of Triton X-100


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Rabbit N-Acylethanolamine-Hydrolyzing Acid Amidase (Naaa) in Complex with Non-Covalent Benzothiazole-Piperazine Inhibitor ARN19702, in Presence of Triton X-100 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K203

b:82.5
occ:1.00
 O A:ARG55 2.7 56.3 1.0
O A:HOH329 3.0 43.8 1.0
O A:TYR57 3.2 44.5 1.0
C A:ARG55 3.8 34.8 1.0
HA A:ARG55 3.9 54.5 0.6
HA A:ARG55 3.9 52.7 0.4
C A:TYR57 3.9 39.1 1.0
H A:TYR57 4.0 39.1 1.0
HA A:ASP58 4.0 49.7 1.0
HG23 A:VAL59 4.2 84.8 1.0
N A:TYR57 4.3 32.5 1.0
H A:VAL59 4.3 45.5 1.0
HG2 A:ARG55 4.4 47.8 0.6
CA A:ARG55 4.4 45.3 0.6
CA A:ARG55 4.4 43.8 0.4
O A:LEU54 4.5 36.3 1.0
HG3 A:ARG55 4.5 47.8 0.4
N A:ASP58 4.6 37.5 1.0
HG2 A:ARG55 4.7 47.8 0.4
C A:HIS56 4.7 31.3 1.0
CA A:ASP58 4.7 41.4 1.0
CA A:TYR57 4.7 38.7 1.0
N A:HIS56 4.8 39.1 1.0
HA A:HIS56 4.8 36.3 1.0
HG3 A:ARG55 4.9 47.8 0.6
N A:VAL59 4.9 37.9 1.0

Reference:

A.Gorelik, A.Gebai, K.Illes, D.Piomelli, B.Nagar. Molecular Mechanism of Activation of the Immunoregulatory Amidase Naaa. Proc. Natl. Acad. Sci. V. 115 10032 2018U.S.A..
ISSN: ESSN 1091-6490
PubMed: 30301806
DOI: 10.1073/PNAS.1811759115
Page generated: Mon Dec 14 00:35:11 2020

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