Potassium in PDB 5yfn: Human Isocitrate Dehydrogenase 1 Bound with Isocitrate

All present enzymatic activity of Human Isocitrate Dehydrogenase 1 Bound with Isocitrate:
1.1.1.42;

The structure of Human Isocitrate Dehydrogenase 1 Bound with Isocitrate, PDB code: 5yfn was solved by P.Nordlund, D.Chen, A.Jansson, A.Larsson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	41.80 / 2.50
Space group	I 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	111.560, 92.000, 138.835, 90.00, 109.94, 90.00
R / Rfree (%)	17.3 / 22.6

The structure of Human Isocitrate Dehydrogenase 1 Bound with Isocitrate also contains other interesting chemical elements:

Magnesium

(Mg)

2 atoms

The binding sites of Potassium atom in the Human Isocitrate Dehydrogenase 1 Bound with Isocitrate (pdb code 5yfn). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Human Isocitrate Dehydrogenase 1 Bound with Isocitrate, PDB code: 5yfn:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in the Human Isocitrate Dehydrogenase 1 Bound with Isocitrate


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Human Isocitrate Dehydrogenase 1 Bound with Isocitrate within 5.0Å range: probe atom residue distance (Å) B Occ A:K504 b:30.6 occ:1.00 HO7 A:ICT505 2.9 20.0 1.0 H42 A:ICT505 3.4 20.0 1.0 O7 A:ICT505 3.6 20.0 1.0 OD1 A:ASP252 3.7 26.3 1.0 OD1 A:ASP253 3.8 34.9 1.0 OD2 A:ASP252 3.9 29.3 1.0 NZ A:LYS212 3.9 21.4 1.0 H2 A:ICT505 4.0 20.0 1.0 CD1 A:LEU250 4.1 19.6 1.0 H41 A:ICT505 4.1 20.0 1.0 C4 A:ICT505 4.2 20.0 1.0 CG A:ASP252 4.2 24.0 1.0 C2 A:ICT505 4.3 20.0 1.0 OD2 A:ASP253 4.6 34.4 1.0 CG A:ASP253 4.6 29.7 1.0 C3 A:ICT505 4.8 20.0 1.0 CB A:LEU250 4.9 23.9 1.0

Potassium binding site 2 out of 2 in the Human Isocitrate Dehydrogenase 1 Bound with Isocitrate


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Human Isocitrate Dehydrogenase 1 Bound with Isocitrate within 5.0Å range: probe atom residue distance (Å) B Occ B:K501 b:38.7 occ:1.00 HO7 A:ICT502 3.3 20.0 1.0 H42 A:ICT502 3.4 20.0 1.0 O A:HOH614 3.7 24.2 1.0 OD2 B:ASP252 3.8 29.2 1.0 OD1 B:ASP253 3.8 48.4 1.0 OD1 B:ASP252 3.9 23.6 1.0 H2 A:ICT502 4.0 20.0 1.0 NZ B:LYS212 4.1 23.4 1.0 CD1 B:LEU250 4.1 21.4 1.0 O7 A:ICT502 4.1 20.0 1.0 CG B:ASP252 4.3 23.8 1.0 OD2 B:ASP253 4.3 44.0 1.0 C4 A:ICT502 4.3 20.0 1.0 C2 A:ICT502 4.4 20.0 1.0 O B:HOH675 4.5 37.1 1.0 CG B:ASP253 4.5 37.1 1.0 H41 A:ICT502 4.6 20.0 1.0 C3 A:ICT502 4.7 20.0 1.0 CB B:LEU250 4.8 23.5 1.0

P.Nordlund, D.Chen, A.Jansson, A.Larsson. Human Isocitrate Dehydrogenase 1 Bound with Isocitrate To Be Published.