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Potassium in PDB 5x24: Crystal Structure of CYP2C9 Genetic Variant I359L (*3) in Complex with Multiple Losartan Molecules
Enzymatic activity of Crystal Structure of CYP2C9 Genetic Variant I359L (*3) in Complex with Multiple Losartan Molecules
All present enzymatic activity of Crystal Structure of CYP2C9 Genetic Variant I359L (*3) in Complex with Multiple Losartan Molecules:
1.14.13.48; 1.14.13.49; 1.14.13.80; 1.14.99.38;
1.14.13.48; 1.14.13.49; 1.14.13.80; 1.14.99.38;
Protein crystallography data
The structure of Crystal Structure of CYP2C9 Genetic Variant I359L (*3) in Complex with Multiple Losartan Molecules, PDB code: 5x24
was solved by
K.Maekawa,
M.Adachi,
M.B.Shah,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 35.78 / 2.48 |
| Space group | I 2 2 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 74.858, 141.777, 160.656, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 22.9 / 27 |
Other elements in 5x24:
The structure of Crystal Structure of CYP2C9 Genetic Variant I359L (*3) in Complex with Multiple Losartan Molecules also contains other interesting chemical elements:
| Iron | (Fe) | 1 atom |
| Chlorine | (Cl) | 2 atoms |
Potassium Binding Sites:
The binding sites of Potassium atom in the Crystal Structure of CYP2C9 Genetic Variant I359L (*3) in Complex with Multiple Losartan Molecules
(pdb code 5x24). This binding sites where shown within
5.0 Angstroms radius around Potassium atom.
In total only one binding site of Potassium was determined in the Crystal Structure of CYP2C9 Genetic Variant I359L (*3) in Complex with Multiple Losartan Molecules, PDB code: 5x24:
In total only one binding site of Potassium was determined in the Crystal Structure of CYP2C9 Genetic Variant I359L (*3) in Complex with Multiple Losartan Molecules, PDB code: 5x24:
Potassium binding site 1 out of 1 in 5x24
Go back to
Potassium Binding Sites List in 5x24
Potassium binding site 1 out
of 1 in the Crystal Structure of CYP2C9 Genetic Variant I359L (*3) in Complex with Multiple Losartan Molecules
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 1 of Crystal Structure of CYP2C9 Genetic Variant I359L (*3) in Complex with Multiple Losartan Molecules within 5.0Å range:
|
Reference:
K.Maekawa,
M.Adachi,
Y.Matsuzawa,
Q.Zhang,
R.Kuroki,
Y.Saito,
M.B.Shah.
Structural Basis of Single-Nucleotide Polymorphisms in Cytochrome P450 2C9 Biochemistry V. 56 5476 2017.
ISSN: ISSN 1520-4995
PubMed: 28972767
DOI: 10.1021/ACS.BIOCHEM.7B00795
Page generated: Mon Aug 12 15:09:24 2024
ISSN: ISSN 1520-4995
PubMed: 28972767
DOI: 10.1021/ACS.BIOCHEM.7B00795
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