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Potassium in PDB 5wsc: Crystal of Pyruvate Kinase (Pyk) From Mycobacterium Tuberculosis in Complex with Oxalate, Soaked with Allosteric Activators Amp and Glucose 6-Phosphate

Enzymatic activity of Crystal of Pyruvate Kinase (Pyk) From Mycobacterium Tuberculosis in Complex with Oxalate, Soaked with Allosteric Activators Amp and Glucose 6-Phosphate

All present enzymatic activity of Crystal of Pyruvate Kinase (Pyk) From Mycobacterium Tuberculosis in Complex with Oxalate, Soaked with Allosteric Activators Amp and Glucose 6-Phosphate:
2.7.1.40;

Protein crystallography data

The structure of Crystal of Pyruvate Kinase (Pyk) From Mycobacterium Tuberculosis in Complex with Oxalate, Soaked with Allosteric Activators Amp and Glucose 6-Phosphate, PDB code: 5wsc was solved by W.Zhong, Q.Cai, A.El Sahili, J.Lescar, P.C.Dedon, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 53.85 / 2.40
Space group P 31
Cell size a, b, c (Å), α, β, γ (°) 124.370, 124.370, 144.192, 90.00, 90.00, 120.00
R / Rfree (%) 17.9 / 22.7

Other elements in 5wsc:

The structure of Crystal of Pyruvate Kinase (Pyk) From Mycobacterium Tuberculosis in Complex with Oxalate, Soaked with Allosteric Activators Amp and Glucose 6-Phosphate also contains other interesting chemical elements:

Magnesium (Mg) 4 atoms

Potassium Binding Sites:

The binding sites of Potassium atom in the Crystal of Pyruvate Kinase (Pyk) From Mycobacterium Tuberculosis in Complex with Oxalate, Soaked with Allosteric Activators Amp and Glucose 6-Phosphate (pdb code 5wsc). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total only one binding site of Potassium was determined in the Crystal of Pyruvate Kinase (Pyk) From Mycobacterium Tuberculosis in Complex with Oxalate, Soaked with Allosteric Activators Amp and Glucose 6-Phosphate, PDB code: 5wsc:

Potassium binding site 1 out of 1 in 5wsc

Go back to Potassium Binding Sites List in 5wsc
Potassium binding site 1 out of 1 in the Crystal of Pyruvate Kinase (Pyk) From Mycobacterium Tuberculosis in Complex with Oxalate, Soaked with Allosteric Activators Amp and Glucose 6-Phosphate


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal of Pyruvate Kinase (Pyk) From Mycobacterium Tuberculosis in Complex with Oxalate, Soaked with Allosteric Activators Amp and Glucose 6-Phosphate within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K505

b:23.8
occ:1.00
 OD1 B:ASN35 2.7 29.1 1.0
OG B:SER37 3.0 27.2 1.0
OD1 B:ASP67 3.0 28.7 1.0
OG B:SER191 3.6 21.9 1.0
CG B:ASP67 3.6 27.0 1.0
CA B:GLN69 3.7 28.1 1.0
O B:LEU68 3.7 24.6 1.0
CG B:ASN35 3.8 30.1 1.0
NZ B:LYS218 3.8 20.6 1.0
OD2 B:ASP67 4.0 27.0 1.0
C B:LEU68 4.0 26.8 1.0
N B:GLN69 4.1 27.7 1.0
O B:ASP67 4.1 24.7 1.0
ND2 B:ASN35 4.2 26.6 1.0
CB B:SER37 4.3 30.2 1.0
C B:ASP67 4.4 24.6 1.0
CB B:ASP67 4.4 26.2 1.0
NH2 B:ARG33 4.5 30.4 1.0
CB B:GLN69 4.5 28.7 1.0
O B:GLN69 4.6 29.7 1.0
C B:GLN69 4.6 29.4 1.0
N B:SER37 4.7 29.6 1.0
CB B:SER191 4.7 21.6 1.0
N B:LEU68 4.8 24.8 1.0
O B:HOH629 4.9 14.8 1.0
CA B:LEU68 4.9 27.9 1.0
CB B:ASN35 5.0 30.4 1.0

Reference:

W.Zhong, L.Cui, B.C.Goh, Q.Cai, P.Ho, Y.H.Chionh, M.Yuan, A.E.Sahili, L.A.Fothergill-Gilmore, M.D.Walkinshaw, J.Lescar, P.C.Dedon. Allosteric Pyruvate Kinase-Based "Logic Gate" Synergistically Senses Energy and Sugar Levels in Mycobacterium Tuberculosis. Nat Commun V. 8 1986 2017.
ISSN: ESSN 2041-1723
PubMed: 29215013
DOI: 10.1038/S41467-017-02086-Y
Page generated: Mon Aug 12 15:00:37 2024

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