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Potassium in PDB 5wsb: Pyruvate Kinase (Pyk) From Mycobacterium Tuberculosis in Complex with Oxalate, Allosteric Activators Amp and Glucose 6-Phosphate

Enzymatic activity of Pyruvate Kinase (Pyk) From Mycobacterium Tuberculosis in Complex with Oxalate, Allosteric Activators Amp and Glucose 6-Phosphate

All present enzymatic activity of Pyruvate Kinase (Pyk) From Mycobacterium Tuberculosis in Complex with Oxalate, Allosteric Activators Amp and Glucose 6-Phosphate:
2.7.1.40;

Protein crystallography data

The structure of Pyruvate Kinase (Pyk) From Mycobacterium Tuberculosis in Complex with Oxalate, Allosteric Activators Amp and Glucose 6-Phosphate, PDB code: 5wsb was solved by W.Zhong, Q.Cai, A.El Sahili, J.Lescar, P.C.Dedon, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 62.82 / 2.25
Space group P 31
Cell size a, b, c (Å), α, β, γ (°) 125.631, 125.631, 144.514, 90.00, 90.00, 120.00
R / Rfree (%) 18.7 / 22.8

Other elements in 5wsb:

The structure of Pyruvate Kinase (Pyk) From Mycobacterium Tuberculosis in Complex with Oxalate, Allosteric Activators Amp and Glucose 6-Phosphate also contains other interesting chemical elements:

Magnesium (Mg) 4 atoms

Potassium Binding Sites:

The binding sites of Potassium atom in the Pyruvate Kinase (Pyk) From Mycobacterium Tuberculosis in Complex with Oxalate, Allosteric Activators Amp and Glucose 6-Phosphate (pdb code 5wsb). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total only one binding site of Potassium was determined in the Pyruvate Kinase (Pyk) From Mycobacterium Tuberculosis in Complex with Oxalate, Allosteric Activators Amp and Glucose 6-Phosphate, PDB code: 5wsb:

Potassium binding site 1 out of 1 in 5wsb

Go back to Potassium Binding Sites List in 5wsb
Potassium binding site 1 out of 1 in the Pyruvate Kinase (Pyk) From Mycobacterium Tuberculosis in Complex with Oxalate, Allosteric Activators Amp and Glucose 6-Phosphate


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Pyruvate Kinase (Pyk) From Mycobacterium Tuberculosis in Complex with Oxalate, Allosteric Activators Amp and Glucose 6-Phosphate within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K505

b:37.6
occ:1.00
 OD1 B:ASN35 2.7 36.0 1.0
OD1 B:ASP67 2.9 40.8 1.0
OG B:SER37 3.1 40.5 1.0
O B:HOH642 3.2 19.2 1.0
CG B:ASP67 3.6 35.2 1.0
OG B:SER191 3.6 31.6 1.0
CG B:ASN35 3.7 37.4 1.0
CA B:GLN69 3.8 34.8 1.0
NZ B:LYS218 3.9 30.5 1.0
OD2 B:ASP67 3.9 31.3 1.0
O B:LEU68 4.0 31.8 1.0
O B:ASP67 4.1 31.1 1.0
C B:LEU68 4.1 33.8 1.0
N B:GLN69 4.1 32.8 1.0
CB B:SER37 4.2 41.2 1.0
ND2 B:ASN35 4.3 35.0 1.0
C B:ASP67 4.4 30.9 1.0
NH2 B:ARG33 4.4 37.6 1.0
N B:SER37 4.5 39.8 1.0
CB B:ASP67 4.5 33.6 1.0
CB B:GLN69 4.7 35.7 1.0
O B:HOH625 4.7 27.3 1.0
C B:GLN69 4.8 36.3 1.0
CB B:SER191 4.8 29.4 1.0
O B:GLN69 4.8 36.9 1.0
N B:LEU68 4.8 32.5 1.0
N B:PHE36 4.9 35.8 1.0
CA B:SER37 4.9 40.6 1.0
CB B:ASN35 5.0 36.5 1.0
CA B:LEU68 5.0 33.9 1.0

Reference:

W.Zhong, L.Cui, B.C.Goh, Q.Cai, P.Ho, Y.H.Chionh, M.Yuan, A.E.Sahili, L.A.Fothergill-Gilmore, M.D.Walkinshaw, J.Lescar, P.C.Dedon. Allosteric Pyruvate Kinase-Based "Logic Gate" Synergistically Senses Energy and Sugar Levels in Mycobacterium Tuberculosis. Nat Commun V. 8 1986 2017.
ISSN: ESSN 2041-1723
PubMed: 29215013
DOI: 10.1038/S41467-017-02086-Y
Page generated: Mon Aug 12 15:00:06 2024

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