Potassium in PDB 5wie: Crystal Structure of A KV1.2-2.1 Chimera K+ Channel V406W Mutant in An Inactivated State

The structure of Crystal Structure of A KV1.2-2.1 Chimera K+ Channel V406W Mutant in An Inactivated State, PDB code: 5wie was solved by V.Pau, Y.Zhou, Y.Ramu, Y.Xu, Z.Lu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	40.00 / 3.30
Space group	P 4 21 2
Cell size a, b, c (Å), α, β, γ (°)	143.124, 143.124, 284.510, 90.00, 90.00, 90.00
R / Rfree (%)	23.6 / 24.3

The binding sites of Potassium atom in the Crystal Structure of A KV1.2-2.1 Chimera K+ Channel V406W Mutant in An Inactivated State (pdb code 5wie). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 8 binding sites of Potassium where determined in the Crystal Structure of A KV1.2-2.1 Chimera K+ Channel V406W Mutant in An Inactivated State, PDB code: 5wie:
Jump to Potassium binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Potassium binding site 1 out of 8 in the Crystal Structure of A KV1.2-2.1 Chimera K+ Channel V406W Mutant in An Inactivated State


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of A KV1.2-2.1 Chimera K+ Channel V406W Mutant in An Inactivated State within 5.0Å range: probe atom residue distance (Å) B Occ B:K506 b:60.3 occ:0.25 O B:VAL371 2.7 42.1 1.0 O B:GLY372 2.8 44.0 1.0 K B:K507 3.2 38.7 0.2 C B:GLY372 3.6 42.8 1.0 C B:VAL371 3.9 41.9 1.0 CA B:GLY372 4.1 42.2 1.0 N B:GLY372 4.5 42.5 1.0 N B:TYR373 4.5 42.5 1.0 O B:TYR373 4.6 41.0 1.0 CA B:TYR373 4.8 40.8 1.0 C B:TYR373 5.0 41.1 1.0

Potassium binding site 2 out of 8 in the Crystal Structure of A KV1.2-2.1 Chimera K+ Channel V406W Mutant in An Inactivated State


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystal Structure of A KV1.2-2.1 Chimera K+ Channel V406W Mutant in An Inactivated State within 5.0Å range: probe atom residue distance (Å) B Occ B:K507 b:38.7 occ:0.25 O B:THR370 2.7 39.5 1.0 O B:VAL371 2.7 42.1 1.0 K B:K506 3.2 60.3 0.2 K B:K508 3.2 33.6 0.2 C B:VAL371 3.5 41.9 1.0 C B:THR370 3.8 39.9 1.0 CA B:VAL371 3.9 40.5 1.0 N B:VAL371 4.4 40.0 1.0 N B:GLY372 4.6 42.5 1.0

Potassium binding site 3 out of 8 in the Crystal Structure of A KV1.2-2.1 Chimera K+ Channel V406W Mutant in An Inactivated State


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Crystal Structure of A KV1.2-2.1 Chimera K+ Channel V406W Mutant in An Inactivated State within 5.0Å range: probe atom residue distance (Å) B Occ B:K508 b:33.6 occ:0.25 O B:THR370 2.9 39.5 1.0 OG1 B:THR370 3.0 34.2 1.0 K B:K507 3.2 38.7 0.2 CB B:THR370 3.7 37.5 1.0 C B:THR370 3.8 39.9 1.0 CA B:THR370 4.4 39.3 1.0 N B:VAL371 4.8 40.0 1.0 O B:THR369 4.9 40.5 1.0 CG2 B:THR370 4.9 35.7 1.0

Potassium binding site 4 out of 8 in the Crystal Structure of A KV1.2-2.1 Chimera K+ Channel V406W Mutant in An Inactivated State


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Crystal Structure of A KV1.2-2.1 Chimera K+ Channel V406W Mutant in An Inactivated State within 5.0Å range:

Potassium binding site 5 out of 8 in the Crystal Structure of A KV1.2-2.1 Chimera K+ Channel V406W Mutant in An Inactivated State


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 5 of Crystal Structure of A KV1.2-2.1 Chimera K+ Channel V406W Mutant in An Inactivated State within 5.0Å range: probe atom residue distance (Å) B Occ H:K502 b:62.5 occ:0.25 O H:TYR373 2.7 58.0 1.0 O H:GLY372 3.3 58.4 1.0 K H:K503 3.4 84.8 0.2 C H:TYR373 3.5 58.3 1.0 CA H:TYR373 4.1 58.0 1.0 N H:GLY374 4.3 59.0 1.0 C H:GLY372 4.4 57.7 1.0 CA H:GLY374 4.5 60.7 1.0 N H:TYR373 4.8 58.2 1.0

Potassium binding site 6 out of 8 in the Crystal Structure of A KV1.2-2.1 Chimera K+ Channel V406W Mutant in An Inactivated State


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 6 of Crystal Structure of A KV1.2-2.1 Chimera K+ Channel V406W Mutant in An Inactivated State within 5.0Å range: probe atom residue distance (Å) B Occ H:K503 b:84.8 occ:0.25 O H:GLY372 2.6 58.4 1.0 O H:VAL371 3.0 56.0 1.0 C H:GLY372 3.4 57.7 1.0 K H:K502 3.4 62.5 0.2 CA H:GLY372 4.0 56.8 1.0 C H:VAL371 4.1 56.7 1.0 K H:K504 4.2 59.0 0.2 N H:TYR373 4.3 58.2 1.0 N H:GLY372 4.5 56.5 1.0 CA H:TYR373 4.6 58.0 1.0 C H:TYR373 4.8 58.3 1.0 O H:TYR373 4.9 58.0 1.0

Potassium binding site 7 out of 8 in the Crystal Structure of A KV1.2-2.1 Chimera K+ Channel V406W Mutant in An Inactivated State


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 7 of Crystal Structure of A KV1.2-2.1 Chimera K+ Channel V406W Mutant in An Inactivated State within 5.0Å range: probe atom residue distance (Å) B Occ H:K504 b:59.0 occ:0.25 O H:THR370 2.5 58.9 1.0 K H:K505 2.8 68.3 0.2 O H:VAL371 3.3 56.0 1.0 C H:THR370 3.7 58.1 1.0 C H:VAL371 3.8 56.7 1.0 CA H:VAL371 4.1 56.7 1.0 K H:K503 4.2 84.8 0.2 OG1 H:THR370 4.3 54.5 1.0 N H:VAL371 4.4 57.1 1.0 CB H:THR370 4.6 56.9 1.0 N H:GLY372 4.8 56.5 1.0 CA H:THR370 4.8 57.7 1.0

Potassium binding site 8 out of 8 in the Crystal Structure of A KV1.2-2.1 Chimera K+ Channel V406W Mutant in An Inactivated State


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 8 of Crystal Structure of A KV1.2-2.1 Chimera K+ Channel V406W Mutant in An Inactivated State within 5.0Å range: probe atom residue distance (Å) B Occ H:K505 b:68.3 occ:0.25 OG1 H:THR370 2.8 54.5 1.0 K H:K504 2.8 59.0 0.2 O H:THR370 3.5 58.9 1.0 CB H:THR370 3.6 56.9 1.0 C H:THR370 4.2 58.1 1.0 CA H:THR370 4.6 57.7 1.0 CG2 H:THR370 4.7 56.5 1.0 O H:THR369 4.9 56.2 1.0

V.Pau, Y.Zhou, Y.Ramu, Y.Xu, Z.Lu. Crystal Structure of An Inactivated Mutant Mammalian Voltage-Gated K(+) Channel. Nat. Struct. Mol. Biol. V. 24 857 2017.
ISSN: ESSN 1545-9985
PubMed: 28846092
DOI: 10.1038/NSMB.3457