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Potassium in PDB 5uuv: Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase From Bacillus Anthracis in the Complex with A Product Imp and the Inhibitor P182

Enzymatic activity of Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase From Bacillus Anthracis in the Complex with A Product Imp and the Inhibitor P182

All present enzymatic activity of Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase From Bacillus Anthracis in the Complex with A Product Imp and the Inhibitor P182:
1.1.1.205;

Protein crystallography data

The structure of Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase From Bacillus Anthracis in the Complex with A Product Imp and the Inhibitor P182, PDB code: 5uuv was solved by Y.Kim, N.Maltseva, R.Mulligan, M.Makowska-Grzyska, M.Gu, D.Gollapalli, L.Hedstrom, W.F.Anderson, A.Joachimiak, Center For Structural Genomicsof Infectious Diseases (Csgid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 46.67 / 2.75
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 85.281, 89.164, 164.297, 90.00, 90.00, 90.00
R / Rfree (%) 19.4 / 24.2

Other elements in 5uuv:

The structure of Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase From Bacillus Anthracis in the Complex with A Product Imp and the Inhibitor P182 also contains other interesting chemical elements:

Fluorine (F) 12 atoms
Chlorine (Cl) 4 atoms

Potassium Binding Sites:

The binding sites of Potassium atom in the Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase From Bacillus Anthracis in the Complex with A Product Imp and the Inhibitor P182 (pdb code 5uuv). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 4 binding sites of Potassium where determined in the Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase From Bacillus Anthracis in the Complex with A Product Imp and the Inhibitor P182, PDB code: 5uuv:
Jump to Potassium binding site number: 1; 2; 3; 4;

Potassium binding site 1 out of 4 in 5uuv

Go back to Potassium Binding Sites List in 5uuv
Potassium binding site 1 out of 4 in the Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase From Bacillus Anthracis in the Complex with A Product Imp and the Inhibitor P182


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase From Bacillus Anthracis in the Complex with A Product Imp and the Inhibitor P182 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K503

b:98.6
occ:1.00
O D:GLU470 2.8 90.7 1.0
O A:GLY303 2.9 47.2 1.0
O A:CYS308 2.9 50.5 1.0
O A:GLY305 3.0 57.6 1.0
O D:SER471 3.0 80.8 1.0
C D:SER471 3.4 77.5 1.0
O D:HIS472 3.6 65.8 1.0
C A:CYS308 3.7 44.8 1.0
CB A:CYS308 3.8 47.7 1.0
CA D:SER471 3.9 80.6 1.0
C D:HIS472 3.9 62.6 1.0
C D:GLU470 3.9 88.1 1.0
C A:GLY303 4.1 45.5 1.0
N D:HIS472 4.1 69.8 1.0
CA A:CYS308 4.2 41.1 1.0
C A:GLY305 4.2 52.7 1.0
SG A:CYS308 4.2 57.7 1.0
C A:PRO304 4.3 45.0 1.0
CE1 D:HIS474 4.3 71.0 1.0
N A:CYS308 4.4 37.4 1.0
N D:PRO473 4.4 61.6 1.0
N A:GLY305 4.4 45.9 1.0
N D:SER471 4.4 86.3 1.0
CA D:HIS472 4.4 63.4 1.0
ND1 D:HIS474 4.5 71.8 1.0
CA A:PRO304 4.5 45.4 1.0
O A:PRO304 4.6 42.0 1.0
N A:THR309 4.7 42.2 1.0
N A:PRO304 4.8 48.1 1.0
CA D:PRO473 4.8 63.0 1.0
CA A:GLY305 4.9 48.9 1.0
CA A:THR309 5.0 40.1 1.0

Potassium binding site 2 out of 4 in 5uuv

Go back to Potassium Binding Sites List in 5uuv
Potassium binding site 2 out of 4 in the Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase From Bacillus Anthracis in the Complex with A Product Imp and the Inhibitor P182


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase From Bacillus Anthracis in the Complex with A Product Imp and the Inhibitor P182 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K504

b:87.9
occ:1.00
O C:GLY305 2.8 48.7 1.0
O C:CYS308 2.8 41.9 1.0
O A:GLU470 2.9 66.2 1.0
O C:GLY303 2.9 41.2 1.0
O A:SER471 3.0 69.9 1.0
O A:HIS472 3.4 46.3 1.0
C A:SER471 3.4 61.1 1.0
C C:CYS308 3.7 38.8 1.0
C A:HIS472 3.7 45.3 1.0
CB C:CYS308 3.8 42.5 1.0
C A:GLU470 4.0 65.8 1.0
C C:GLY305 4.0 45.2 1.0
N A:HIS472 4.0 51.1 1.0
C C:GLY303 4.0 43.4 1.0
CA A:SER471 4.0 61.5 1.0
C C:PRO304 4.1 44.8 1.0
CA C:CYS308 4.1 36.8 1.0
N A:PRO473 4.2 43.9 1.0
N C:GLY305 4.2 45.6 1.0
CA A:HIS472 4.2 46.2 1.0
N C:CYS308 4.3 35.9 1.0
O C:PRO304 4.4 44.7 1.0
SG C:CYS308 4.4 48.1 1.0
CA C:PRO304 4.4 41.1 1.0
N A:SER471 4.5 64.6 1.0
CD2 A:HIS474 4.5 45.5 1.0
CA A:PRO473 4.6 43.7 1.0
NE2 A:HIS474 4.6 38.4 1.0
CA C:GLY305 4.7 45.3 1.0
N C:PRO304 4.7 42.6 1.0
N C:THR309 4.7 38.4 1.0
CD A:PRO473 4.9 42.0 1.0
CA C:GLY303 5.0 42.2 1.0

Potassium binding site 3 out of 4 in 5uuv

Go back to Potassium Binding Sites List in 5uuv
Potassium binding site 3 out of 4 in the Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase From Bacillus Anthracis in the Complex with A Product Imp and the Inhibitor P182


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase From Bacillus Anthracis in the Complex with A Product Imp and the Inhibitor P182 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K503

b:0.5
occ:1.00
O B:GLY305 2.8 53.8 1.0
O B:GLY303 2.9 56.9 1.0
O B:CYS308 2.9 41.5 1.0
O C:SER471 3.1 82.0 1.0
O C:GLU470 3.1 90.7 1.0
C C:SER471 3.6 78.5 1.0
O C:HIS472 3.6 81.1 1.0
C B:CYS308 3.6 39.1 1.0
CB B:CYS308 3.7 43.0 1.0
C C:HIS472 3.9 78.3 1.0
C B:GLY305 4.0 45.2 1.0
C B:GLY303 4.0 54.3 1.0
CA B:CYS308 4.0 40.8 1.0
N C:HIS472 4.2 78.0 1.0
C B:PRO304 4.2 48.2 1.0
CA C:SER471 4.2 76.1 1.0
N B:CYS308 4.2 46.1 1.0
C C:GLU470 4.2 90.7 1.0
SG B:CYS308 4.2 54.2 1.0
N B:GLY305 4.2 43.1 1.0
N C:PRO473 4.3 73.7 1.0
CA C:HIS472 4.4 76.9 1.0
CA B:PRO304 4.5 47.8 1.0
O B:PRO304 4.5 53.9 1.0
CE1 C:HIS474 4.5 77.2 1.0
CA C:PRO473 4.7 76.1 1.0
ND1 C:HIS474 4.7 78.4 1.0
N B:THR309 4.7 43.6 1.0
N C:SER471 4.7 81.0 1.0
CA B:GLY305 4.7 44.2 1.0
N B:PRO304 4.7 53.4 1.0
CD C:PRO473 4.9 65.8 1.0
CA B:GLY303 5.0 51.1 1.0

Potassium binding site 4 out of 4 in 5uuv

Go back to Potassium Binding Sites List in 5uuv
Potassium binding site 4 out of 4 in the Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase From Bacillus Anthracis in the Complex with A Product Imp and the Inhibitor P182


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase From Bacillus Anthracis in the Complex with A Product Imp and the Inhibitor P182 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K505

b:77.8
occ:1.00
O D:GLY305 2.8 40.8 1.0
O D:CYS308 2.8 41.3 1.0
O B:GLU470 2.8 65.3 1.0
O B:SER471 2.9 65.0 1.0
O D:GLY303 3.1 55.7 1.0
C B:SER471 3.3 56.1 1.0
O B:HIS472 3.5 60.8 1.0
C B:HIS472 3.6 58.3 1.0
C D:CYS308 3.7 38.2 1.0
N B:HIS472 3.8 51.6 1.0
CB D:CYS308 3.8 39.3 1.0
CA B:SER471 3.9 56.1 1.0
C B:GLU470 3.9 61.3 1.0
C D:GLY305 4.0 37.0 1.0
N B:PRO473 4.1 56.7 1.0
CA B:HIS472 4.1 53.9 1.0
CA D:CYS308 4.1 36.4 1.0
C D:GLY303 4.2 50.0 1.0
C D:PRO304 4.2 42.4 1.0
N D:CYS308 4.2 38.0 1.0
N D:GLY305 4.2 43.7 1.0
N B:SER471 4.4 56.6 1.0
SG D:CYS308 4.4 52.0 1.0
O D:PRO304 4.4 33.5 1.0
CA B:PRO473 4.5 55.9 1.0
CA D:PRO304 4.5 43.7 1.0
CD2 B:HIS474 4.6 45.9 1.0
CA D:GLY305 4.7 40.3 1.0
N D:THR309 4.7 34.5 1.0
CD B:PRO473 4.8 52.2 1.0
NE2 B:HIS474 4.8 45.9 1.0
N D:PRO304 4.8 47.6 1.0

Reference:

Y.Kim, N.Maltseva, R.Mulligan, M.Makowska-Grzyska, M.Gu, D.Gollapalli, L.Hedstrom, W.F.Anderson, A.Joachimiak, Center For Structural Genomics Of Infectious Diseases(Csgid). Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase From Bacillus Anthracis in the Complex with A Product Imp and the Inhibitor P182 To Be Published.
Page generated: Mon Dec 14 00:08:39 2020

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