Potassium in PDB 5un2: Crystal Structure of Mouse Cadherin-23 EC19-21 with Non-Syndromic Deafness (DFNB12) Associated Mutation R2029W

The structure of Crystal Structure of Mouse Cadherin-23 EC19-21 with Non-Syndromic Deafness (DFNB12) Associated Mutation R2029W, PDB code: 5un2 was solved by A.Jaiganesh, M.Sotomayor, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 2.96
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	189.475, 73.908, 49.375, 90.00, 96.62, 90.00
R / Rfree (%)	19.6 / 23.6

The structure of Crystal Structure of Mouse Cadherin-23 EC19-21 with Non-Syndromic Deafness (DFNB12) Associated Mutation R2029W also contains other interesting chemical elements:

Calcium

(Ca)

8 atoms

The binding sites of Potassium atom in the Crystal Structure of Mouse Cadherin-23 EC19-21 with Non-Syndromic Deafness (DFNB12) Associated Mutation R2029W (pdb code 5un2). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Crystal Structure of Mouse Cadherin-23 EC19-21 with Non-Syndromic Deafness (DFNB12) Associated Mutation R2029W, PDB code: 5un2:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in the Crystal Structure of Mouse Cadherin-23 EC19-21 with Non-Syndromic Deafness (DFNB12) Associated Mutation R2029W


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of Mouse Cadherin-23 EC19-21 with Non-Syndromic Deafness (DFNB12) Associated Mutation R2029W within 5.0Å range: probe atom residue distance (Å) B Occ A:K2309 b:38.7 occ:1.00 O A:HOH2401 2.5 40.0 1.0 OD1 A:ASP1966 2.5 42.2 1.0 O A:ASP1968 2.7 45.0 1.0 O A:VAL1971 2.8 47.6 1.0 OD2 A:ASP1966 3.1 41.8 1.0 CG A:ASP1966 3.2 41.7 1.0 C A:ASP1968 3.9 44.8 1.0 C A:VAL1971 4.0 49.5 1.0 CA A:TYR1972 4.2 51.2 1.0 CA A:GLU1969 4.3 46.7 1.0 C A:GLU1969 4.5 48.5 1.0 N A:TYR1972 4.6 51.2 1.0 N A:GLU1969 4.6 45.5 1.0 O A:ASP1966 4.6 43.3 1.0 CB A:ASP1966 4.7 41.3 1.0 O A:GLU1969 4.7 51.4 1.0 N A:ASP1970 5.0 48.2 1.0 N A:ALA1973 5.0 47.5 1.0

Potassium binding site 2 out of 2 in the Crystal Structure of Mouse Cadherin-23 EC19-21 with Non-Syndromic Deafness (DFNB12) Associated Mutation R2029W


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystal Structure of Mouse Cadherin-23 EC19-21 with Non-Syndromic Deafness (DFNB12) Associated Mutation R2029W within 5.0Å range: probe atom residue distance (Å) B Occ A:K2310 b:37.6 occ:1.00 OD1 A:ASP2022 2.6 44.9 1.0 O A:ILE2023 2.6 47.7 1.0 CG A:ASP2022 3.7 43.5 1.0 C A:ILE2023 3.8 48.8 1.0 OD2 A:ASP2022 4.2 42.8 1.0 N A:ILE2023 4.2 46.4 1.0 O A:HOH2408 4.3 48.3 1.0 CB A:ALA1973 4.4 44.9 1.0 CA A:ILE2023 4.4 48.9 1.0 C A:ASP2022 4.7 45.0 1.0 CG A:GLN2025 4.7 43.7 1.0 CB A:ILE2023 4.7 51.6 1.0 NE2 A:GLN2025 4.9 45.3 1.0 N A:GLY2024 4.9 49.9 1.0

A.Jaiganesh, P.De-La-Torre, A.A.Patel, D.J.Termine, F.Velez-Cortes, C.Chen, M.Sotomayor. Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness. Structure V. 26 1210 2018.
ISSN: ISSN 1878-4186
PubMed: 30033219
DOI: 10.1016/J.STR.2018.06.003