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Potassium in PDB 5scl: Structure of Liver Pyruvate Kinase in Complex with Anthraquinone Derivative 1
Enzymatic activity of Structure of Liver Pyruvate Kinase in Complex with Anthraquinone Derivative 1
All present enzymatic activity of Structure of Liver Pyruvate Kinase in Complex with Anthraquinone Derivative 1:
2.7.1.40;
2.7.1.40;
Protein crystallography data
The structure of Structure of Liver Pyruvate Kinase in Complex with Anthraquinone Derivative 1, PDB code: 5scl
was solved by
A.Lulla,
A.Foller,
A.Nain-Perez,
M.Grotli,
P.Brear,
M.Hyvonen,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 187.75 / 2.13 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 206.875, 112.269, 187.907, 90, 92.32, 90 |
| R / Rfree (%) | 19.8 / 22.2 |
Other elements in 5scl:
The structure of Structure of Liver Pyruvate Kinase in Complex with Anthraquinone Derivative 1 also contains other interesting chemical elements:
| Magnesium | (Mg) | 8 atoms |
Potassium Binding Sites:
The binding sites of Potassium atom in the Structure of Liver Pyruvate Kinase in Complex with Anthraquinone Derivative 1
(pdb code 5scl). This binding sites where shown within
5.0 Angstroms radius around Potassium atom.
In total 8 binding sites of Potassium where determined in the Structure of Liver Pyruvate Kinase in Complex with Anthraquinone Derivative 1, PDB code: 5scl:
Jump to Potassium binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
In total 8 binding sites of Potassium where determined in the Structure of Liver Pyruvate Kinase in Complex with Anthraquinone Derivative 1, PDB code: 5scl:
Jump to Potassium binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
Potassium binding site 1 out of 8 in 5scl
Go back to
Potassium Binding Sites List in 5scl
Potassium binding site 1 out
of 8 in the Structure of Liver Pyruvate Kinase in Complex with Anthraquinone Derivative 1
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 1 of Structure of Liver Pyruvate Kinase in Complex with Anthraquinone Derivative 1 within 5.0Å range:
|
Potassium binding site 2 out of 8 in 5scl
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Potassium Binding Sites List in 5scl
Potassium binding site 2 out
of 8 in the Structure of Liver Pyruvate Kinase in Complex with Anthraquinone Derivative 1
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 2 of Structure of Liver Pyruvate Kinase in Complex with Anthraquinone Derivative 1 within 5.0Å range:
|
Potassium binding site 3 out of 8 in 5scl
Go back to
Potassium Binding Sites List in 5scl
Potassium binding site 3 out
of 8 in the Structure of Liver Pyruvate Kinase in Complex with Anthraquinone Derivative 1
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 3 of Structure of Liver Pyruvate Kinase in Complex with Anthraquinone Derivative 1 within 5.0Å range:
|
Potassium binding site 4 out of 8 in 5scl
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Potassium Binding Sites List in 5scl
Potassium binding site 4 out
of 8 in the Structure of Liver Pyruvate Kinase in Complex with Anthraquinone Derivative 1
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 4 of Structure of Liver Pyruvate Kinase in Complex with Anthraquinone Derivative 1 within 5.0Å range:
|
Potassium binding site 5 out of 8 in 5scl
Go back to
Potassium Binding Sites List in 5scl
Potassium binding site 5 out
of 8 in the Structure of Liver Pyruvate Kinase in Complex with Anthraquinone Derivative 1
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 5 of Structure of Liver Pyruvate Kinase in Complex with Anthraquinone Derivative 1 within 5.0Å range:
|
Potassium binding site 6 out of 8 in 5scl
Go back to
Potassium Binding Sites List in 5scl
Potassium binding site 6 out
of 8 in the Structure of Liver Pyruvate Kinase in Complex with Anthraquinone Derivative 1
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 6 of Structure of Liver Pyruvate Kinase in Complex with Anthraquinone Derivative 1 within 5.0Å range:
|
Potassium binding site 7 out of 8 in 5scl
Go back to
Potassium Binding Sites List in 5scl
Potassium binding site 7 out
of 8 in the Structure of Liver Pyruvate Kinase in Complex with Anthraquinone Derivative 1
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 7 of Structure of Liver Pyruvate Kinase in Complex with Anthraquinone Derivative 1 within 5.0Å range:
|
Potassium binding site 8 out of 8 in 5scl
Go back to
Potassium Binding Sites List in 5scl
Potassium binding site 8 out
of 8 in the Structure of Liver Pyruvate Kinase in Complex with Anthraquinone Derivative 1
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Potassium with other atoms in the K binding
site number 8 of Structure of Liver Pyruvate Kinase in Complex with Anthraquinone Derivative 1 within 5.0Å range:
|
Reference:
A.Nain-Perez,
A.Foller Fuchtbauer,
L.Haversen,
A.Lulla,
C.Gao,
J.Matic,
L.Monjas,
A.Rodriguez,
P.Brear,
W.Kim,
M.Hyvonen,
J.Boren,
A.Mardinoglu,
M.Uhlen,
M.Grotli.
Anthraquinone Derivatives As Adp-Competitive Inhibitors of Liver Pyruvate Kinase. Eur.J.Med.Chem. V. 234 14270 2022.
ISSN: ISSN 0223-5234
PubMed: 35290845
DOI: 10.1016/J.EJMECH.2022.114270
Page generated: Sat Aug 9 09:45:17 2025
ISSN: ISSN 0223-5234
PubMed: 35290845
DOI: 10.1016/J.EJMECH.2022.114270
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