Potassium in PDB 5kum: Crystal Structure of Inward Rectifier KIR2.2 K62W Mutant in Complex with PIP2

The structure of Crystal Structure of Inward Rectifier KIR2.2 K62W Mutant in Complex with PIP2, PDB code: 5kum was solved by S.-J.Lee, F.Ren, S.Heyman, P.Yuan, C.G.Nichols, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	91.95 / 2.80
Space group	I 4
Cell size a, b, c (Å), α, β, γ (°)	81.303, 81.303, 183.572, 90.00, 90.00, 90.00
R / Rfree (%)	19.8 / 25.8

The binding sites of Potassium atom in the Crystal Structure of Inward Rectifier KIR2.2 K62W Mutant in Complex with PIP2 (pdb code 5kum). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 8 binding sites of Potassium where determined in the Crystal Structure of Inward Rectifier KIR2.2 K62W Mutant in Complex with PIP2, PDB code: 5kum:
Jump to Potassium binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Potassium binding site 1 out of 8 in the Crystal Structure of Inward Rectifier KIR2.2 K62W Mutant in Complex with PIP2


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of Inward Rectifier KIR2.2 K62W Mutant in Complex with PIP2 within 5.0Å range: probe atom residue distance (Å) B Occ A:K402 b:82.5 occ:0.25 K A:K403 2.6 67.6 0.2 O A:GLY145 2.9 53.0 1.0 O A:TYR146 3.1 54.4 1.0 C A:TYR146 3.6 54.0 1.0 C A:GLY145 4.1 54.9 1.0 CA A:TYR146 4.1 52.7 1.0 N A:GLY147 4.4 57.8 1.0 CA A:GLY147 4.6 62.4 1.0 N A:TYR146 4.6 55.9 1.0

Potassium binding site 2 out of 8 in the Crystal Structure of Inward Rectifier KIR2.2 K62W Mutant in Complex with PIP2


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystal Structure of Inward Rectifier KIR2.2 K62W Mutant in Complex with PIP2 within 5.0Å range: probe atom residue distance (Å) B Occ A:K403 b:67.6 occ:0.25 O A:GLY145 2.6 53.0 1.0 K A:K402 2.6 82.5 0.2 O A:ILE144 3.1 46.9 1.0 K A:K404 3.3 80.4 0.2 C A:GLY145 3.6 54.9 1.0 C A:ILE144 4.2 44.9 1.0 CA A:GLY145 4.3 52.1 1.0 N A:TYR146 4.5 55.9 1.0 N A:GLY145 4.7 49.2 1.0 CA A:TYR146 4.7 52.7 1.0 O A:TYR146 4.9 54.4 1.0 C A:TYR146 5.0 54.0 1.0

Potassium binding site 3 out of 8 in the Crystal Structure of Inward Rectifier KIR2.2 K62W Mutant in Complex with PIP2


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Crystal Structure of Inward Rectifier KIR2.2 K62W Mutant in Complex with PIP2 within 5.0Å range: probe atom residue distance (Å) B Occ A:K404 b:80.4 occ:0.25 O A:THR143 2.7 36.9 1.0 K A:K405 2.8 57.4 0.2 O A:ILE144 3.0 46.9 1.0 K A:K403 3.3 67.6 0.2 C A:ILE144 3.7 44.9 1.0 C A:THR143 3.9 40.0 1.0 CA A:ILE144 4.1 42.9 1.0 N A:ILE144 4.6 40.6 1.0 N A:GLY145 4.6 49.2 1.0 OG1 A:THR143 4.7 35.4 1.0 O A:GLY145 4.9 53.0 1.0

Potassium binding site 4 out of 8 in the Crystal Structure of Inward Rectifier KIR2.2 K62W Mutant in Complex with PIP2


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Crystal Structure of Inward Rectifier KIR2.2 K62W Mutant in Complex with PIP2 within 5.0Å range: probe atom residue distance (Å) B Occ A:K405 b:57.4 occ:0.25 O A:THR143 2.7 36.9 1.0 K A:K404 2.8 80.4 0.2 OG1 A:THR143 2.8 35.4 1.0 C A:THR143 3.8 40.0 1.0 CB A:THR143 3.8 39.5 1.0 CA A:THR143 4.5 40.6 1.0 N A:ILE144 4.7 40.6 1.0 CA A:ILE144 4.8 42.9 1.0 O A:THR142 5.0 44.6 1.0

Potassium binding site 5 out of 8 in the Crystal Structure of Inward Rectifier KIR2.2 K62W Mutant in Complex with PIP2


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 5 of Crystal Structure of Inward Rectifier KIR2.2 K62W Mutant in Complex with PIP2 within 5.0Å range: probe atom residue distance (Å) B Occ A:K406 b:0.4 occ:0.25 O A:HOH537 4.8 75.4 1.0

Potassium binding site 6 out of 8 in the Crystal Structure of Inward Rectifier KIR2.2 K62W Mutant in Complex with PIP2


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 6 of Crystal Structure of Inward Rectifier KIR2.2 K62W Mutant in Complex with PIP2 within 5.0Å range: probe atom residue distance (Å) B Occ A:K407 b:0.1 occ:0.25 O A:HOH538 3.5 55.4 1.0

Potassium binding site 7 out of 8 in the Crystal Structure of Inward Rectifier KIR2.2 K62W Mutant in Complex with PIP2


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 7 of Crystal Structure of Inward Rectifier KIR2.2 K62W Mutant in Complex with PIP2 within 5.0Å range:

Potassium binding site 8 out of 8 in the Crystal Structure of Inward Rectifier KIR2.2 K62W Mutant in Complex with PIP2


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 8 of Crystal Structure of Inward Rectifier KIR2.2 K62W Mutant in Complex with PIP2 within 5.0Å range: probe atom residue distance (Å) B Occ A:K409 b:0.1 occ:0.25 O A:ASP256 4.9 79.1 1.0

S.J.Lee, F.Ren, E.M.Zangerl-Plessl, S.Heyman, A.Stary-Weinzinger, P.Yuan, C.G.Nichols. Structural Basis of Control of Inward Rectifier KIR2 Channel Gating By Bulk Anionic Phospholipids. J.Gen.Physiol. V. 148 227 2016.
ISSN: ESSN 1540-7748
PubMed: 27527100
DOI: 10.1085/JGP.201611616