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Potassium in PDB 5fog: Crystal Structure of Hte Cryptosporidium Muris Cytosolic Leucyl-Trna Synthetase Editing Domain Complex with A Post- Transfer Editing Analogue of Norvaline (NV2AA)

Enzymatic activity of Crystal Structure of Hte Cryptosporidium Muris Cytosolic Leucyl-Trna Synthetase Editing Domain Complex with A Post- Transfer Editing Analogue of Norvaline (NV2AA)

All present enzymatic activity of Crystal Structure of Hte Cryptosporidium Muris Cytosolic Leucyl-Trna Synthetase Editing Domain Complex with A Post- Transfer Editing Analogue of Norvaline (NV2AA):
6.1.1.4;

Protein crystallography data

The structure of Crystal Structure of Hte Cryptosporidium Muris Cytosolic Leucyl-Trna Synthetase Editing Domain Complex with A Post- Transfer Editing Analogue of Norvaline (NV2AA), PDB code: 5fog was solved by A.Palencia, R.J.Liu, M.Lukarska, J.Gut, A.Bougdour, B.Touquet, E.D.Wang, M.R.K.Alley, P.J.Rosenthal, M.A.Hakimi, S.Cusack, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 101.76 / 2.30
Space group P 41 21 2
Cell size a, b, c (Å), α, β, γ (°) 107.730, 107.730, 309.510, 90.00, 90.00, 90.00
R / Rfree (%) 20.087 / 23.607

Potassium Binding Sites:

The binding sites of Potassium atom in the Crystal Structure of Hte Cryptosporidium Muris Cytosolic Leucyl-Trna Synthetase Editing Domain Complex with A Post- Transfer Editing Analogue of Norvaline (NV2AA) (pdb code 5fog). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Crystal Structure of Hte Cryptosporidium Muris Cytosolic Leucyl-Trna Synthetase Editing Domain Complex with A Post- Transfer Editing Analogue of Norvaline (NV2AA), PDB code: 5fog:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in 5fog

Go back to Potassium Binding Sites List in 5fog
Potassium binding site 1 out of 2 in the Crystal Structure of Hte Cryptosporidium Muris Cytosolic Leucyl-Trna Synthetase Editing Domain Complex with A Post- Transfer Editing Analogue of Norvaline (NV2AA)


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of Hte Cryptosporidium Muris Cytosolic Leucyl-Trna Synthetase Editing Domain Complex with A Post- Transfer Editing Analogue of Norvaline (NV2AA) within 5.0Å range:
probe atom residue distance (Å) B Occ
C:K1545

b:46.5
occ:1.00
 O C:HOH2046 2.6 30.5 1.0
O C:THR401 2.8 32.7 1.0
O C:ALA398 2.8 32.4 1.0
O C:HOH2049 3.0 43.8 1.0
O C:TYR403 3.1 31.1 1.0
O C:HOH2044 3.6 29.7 1.0
C C:THR401 3.9 31.9 1.0
C C:ALA398 4.0 31.3 1.0
CG2 C:THR401 4.0 34.3 1.0
C C:TYR403 4.1 28.9 1.0
N C:ALA398 4.3 28.6 1.0
O C:HOH2052 4.4 54.1 1.0
CA C:SER404 4.4 31.5 1.0
O C:SER404 4.5 30.2 1.0
N C:THR401 4.6 35.8 1.0
N C:SER404 4.6 30.2 1.0
CA C:THR401 4.7 33.4 1.0
CA C:ALA398 4.7 29.6 1.0
C C:PRO402 4.7 30.6 1.0
C C:SER404 4.7 30.8 1.0
N C:TYR403 4.8 29.8 1.0
OG C:SER397 4.8 34.2 1.0
N C:PRO402 4.9 29.6 1.0
CA C:PRO402 4.9 29.8 1.0
C C:PRO399 4.9 33.5 1.0
N C:MET400 4.9 35.8 1.0
N C:PRO399 4.9 34.3 1.0
CB C:THR401 5.0 34.4 1.0
CA C:PRO399 5.0 34.8 1.0

Potassium binding site 2 out of 2 in 5fog

Go back to Potassium Binding Sites List in 5fog
Potassium binding site 2 out of 2 in the Crystal Structure of Hte Cryptosporidium Muris Cytosolic Leucyl-Trna Synthetase Editing Domain Complex with A Post- Transfer Editing Analogue of Norvaline (NV2AA)


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystal Structure of Hte Cryptosporidium Muris Cytosolic Leucyl-Trna Synthetase Editing Domain Complex with A Post- Transfer Editing Analogue of Norvaline (NV2AA) within 5.0Å range:
probe atom residue distance (Å) B Occ
D:K1543

b:40.3
occ:1.00
 O D:HOH2034 2.7 39.4 1.0
O D:THR401 2.7 33.1 1.0
O D:ALA398 2.8 29.6 1.0
O D:HOH2035 2.9 52.4 1.0
O D:HOH2038 2.9 43.4 1.0
O D:TYR403 2.9 34.9 1.0
O D:HOH2032 3.6 31.2 1.0
O D:HOH2037 3.7 54.6 1.0
C D:THR401 3.9 33.6 1.0
C D:TYR403 4.0 34.7 1.0
C D:ALA398 4.0 30.6 1.0
CG2 D:THR401 4.0 30.7 1.0
N D:ALA398 4.3 31.8 1.0
N D:THR401 4.5 34.6 1.0
O D:SER404 4.5 31.9 1.0
CA D:SER404 4.5 36.0 1.0
CA D:THR401 4.6 33.0 1.0
C D:PRO402 4.6 34.5 1.0
N D:SER404 4.7 35.1 1.0
N D:TYR403 4.7 34.1 1.0
CA D:ALA398 4.7 30.4 1.0
C D:SER404 4.8 33.2 1.0
N D:PRO402 4.9 34.4 1.0
O D:PRO402 4.9 36.0 1.0
CB D:THR401 4.9 31.9 1.0
C D:PRO399 4.9 34.3 1.0
N D:MET400 4.9 35.7 1.0
CA D:PRO402 4.9 34.1 1.0
OG D:SER397 5.0 34.1 1.0
CA D:TYR403 5.0 32.7 1.0
N D:PRO399 5.0 32.6 1.0

Reference:

A.Palencia, R.Liu, M.Lukarska, J.Gut, A.Bougdour, B.Touquet, E.Wang, X.Li, M.R.K.Alley, Y.R.Freund, P.J.Rosenthal, M.Hakimi, S.Cusack. Cryptosporidium and Toxoplasma Parasites Are Inhibited By A Benzoxaborole Targeting Leucyl-Trna Synthetase. Antimicrob.Agents Chemother. V. 60 5817 2016.
ISSN: ISSN 0066-4804
PubMed: 27431220
DOI: 10.1128/AAC.00873-16
Page generated: Mon Aug 12 13:34:34 2024

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