Potassium in PDB 5ew7: Crystal Structure of C9ORF72 Antisense Ccccgg Repeat Rna Associated with Lou Gehrig'S Disease and Frontotemporal Dementia, Crystallized with BA2+

The structure of Crystal Structure of C9ORF72 Antisense Ccccgg Repeat Rna Associated with Lou Gehrig'S Disease and Frontotemporal Dementia, Crystallized with BA2+, PDB code: 5ew7 was solved by D.R.Tomchick, D.W.Dodd, K.T.Gagnon, D.R.Corey, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	37.20 / 1.75
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	41.134, 47.659, 59.495, 90.00, 90.00, 90.00
R / Rfree (%)	23.5 / 25.8

The structure of Crystal Structure of C9ORF72 Antisense Ccccgg Repeat Rna Associated with Lou Gehrig'S Disease and Frontotemporal Dementia, Crystallized with BA2+ also contains other interesting chemical elements:

Magnesium	(Mg)	4 atoms
Barium	(Ba)	1 atom

The binding sites of Potassium atom in the Crystal Structure of C9ORF72 Antisense Ccccgg Repeat Rna Associated with Lou Gehrig'S Disease and Frontotemporal Dementia, Crystallized with BA2+ (pdb code 5ew7). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 4 binding sites of Potassium where determined in the Crystal Structure of C9ORF72 Antisense Ccccgg Repeat Rna Associated with Lou Gehrig'S Disease and Frontotemporal Dementia, Crystallized with BA2+, PDB code: 5ew7:
Jump to Potassium binding site number: 1; 2; 3; 4;

Potassium binding site 1 out of 4 in the Crystal Structure of C9ORF72 Antisense Ccccgg Repeat Rna Associated with Lou Gehrig'S Disease and Frontotemporal Dementia, Crystallized with BA2+


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of C9ORF72 Antisense Ccccgg Repeat Rna Associated with Lou Gehrig'S Disease and Frontotemporal Dementia, Crystallized with BA2+ within 5.0Å range: probe atom residue distance (Å) B Occ A:K101 b:27.2 occ:1.00 N7 A:G5 2.6 28.8 1.0 O A:HOH206 2.7 13.8 1.0 O A:HOH242 2.7 29.1 1.0 O A:HOH220 2.8 34.9 1.0 O A:HOH209 2.8 25.1 1.0 O A:HOH208 2.8 26.7 1.0 O A:HOH224 2.8 27.0 1.0 O6 A:G5 2.8 25.0 1.0 C5 A:G5 3.2 27.4 1.0 C6 A:G5 3.3 25.7 1.0 H5 A:C4 3.7 39.1 1.0 C8 A:G5 3.7 29.8 1.0 C5 A:C4 4.1 32.6 1.0 H8 A:G5 4.1 35.8 1.0 H41 A:C4 4.1 40.1 1.0 O A:HOH227 4.2 32.0 1.0 O A:HOH221 4.4 34.4 1.0 N4 A:C4 4.4 33.4 1.0 O6 A:G6 4.4 21.8 1.0 C4 A:C4 4.5 33.0 1.0 N7 A:G6 4.5 23.7 1.0 C4 A:G5 4.5 28.0 1.0 OP2 A:C4 4.5 33.9 1.0 H42 B:C20 4.7 27.2 1.0 N1 A:G5 4.7 25.3 1.0 C6 A:C4 4.7 32.9 1.0 N9 A:G5 4.8 29.7 1.0 H6 A:C4 4.9 39.4 1.0 O A:HOH244 4.9 23.2 1.0 H42 A:C4 5.0 40.1 1.0 OP2 A:C3 5.0 42.2 1.0

Potassium binding site 2 out of 4 in the Crystal Structure of C9ORF72 Antisense Ccccgg Repeat Rna Associated with Lou Gehrig'S Disease and Frontotemporal Dementia, Crystallized with BA2+


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystal Structure of C9ORF72 Antisense Ccccgg Repeat Rna Associated with Lou Gehrig'S Disease and Frontotemporal Dementia, Crystallized with BA2+ within 5.0Å range: probe atom residue distance (Å) B Occ B:K102 b:19.3 occ:1.00 OP2 B:G17 2.7 17.0 1.0 O B:HOH207 2.7 26.5 1.0 O B:HOH204 2.8 29.6 1.0 O B:HOH216 2.8 33.3 1.0 O B:HOH251 3.2 21.1 1.0 O A:HOH244 3.6 23.2 1.0 P B:G17 3.8 17.4 1.0 O5' B:G17 4.0 12.7 1.0 OP2 B:G18 4.2 15.1 1.0 H8 B:G17 4.2 15.6 1.0 O B:HOH215 4.3 30.4 1.0 H3' B:G17 4.5 17.5 1.0 O B:HOH220 4.5 27.5 1.0 N7 B:G17 4.5 12.7 1.0 C8 B:G17 4.6 13.0 1.0 OP1 B:G17 4.6 16.2 1.0 H3' B:C16 4.6 20.4 1.0 O B:HOH226 4.7 27.0 1.0 OP2 B:C16 4.8 20.6 1.0 O B:HOH241 5.0 27.4 1.0 O B:HOH230 5.0 29.6 1.0

Potassium binding site 3 out of 4 in the Crystal Structure of C9ORF72 Antisense Ccccgg Repeat Rna Associated with Lou Gehrig'S Disease and Frontotemporal Dementia, Crystallized with BA2+


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Crystal Structure of C9ORF72 Antisense Ccccgg Repeat Rna Associated with Lou Gehrig'S Disease and Frontotemporal Dementia, Crystallized with BA2+ within 5.0Å range: probe atom residue distance (Å) B Occ B:K103 b:28.8 occ:1.00 N7 B:G5 2.6 31.7 1.0 O B:HOH214 2.6 10.5 1.0 O B:HOH211 2.8 28.4 1.0 O B:HOH253 2.8 36.3 1.0 O6 B:G5 2.8 28.5 1.0 O B:HOH238 2.8 29.8 1.0 O B:HOH234 3.1 32.6 1.0 C5 B:G5 3.2 31.2 1.0 C6 B:G5 3.3 29.7 1.0 H5 B:C4 3.4 45.2 1.0 C8 B:G5 3.8 33.3 1.0 H41 B:C4 3.8 43.9 1.0 C5 B:C4 3.8 37.7 1.0 H8 B:G5 4.1 40.0 1.0 N4 B:C4 4.2 36.6 1.0 C4 B:C4 4.3 37.7 1.0 OP2 B:C4 4.4 33.2 1.0 C4 B:G5 4.5 32.5 1.0 C6 B:C4 4.6 38.9 1.0 H42 A:C20 4.6 32.6 1.0 O6 B:G6 4.6 25.4 1.0 N1 B:G5 4.7 29.8 1.0 H6 B:C4 4.7 46.7 1.0 N7 B:G6 4.7 28.8 1.0 H42 B:C4 4.8 43.9 1.0 N9 B:G5 4.8 33.9 1.0 OP2 B:C3 4.9 31.6 1.0

Potassium binding site 4 out of 4 in the Crystal Structure of C9ORF72 Antisense Ccccgg Repeat Rna Associated with Lou Gehrig'S Disease and Frontotemporal Dementia, Crystallized with BA2+


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Crystal Structure of C9ORF72 Antisense Ccccgg Repeat Rna Associated with Lou Gehrig'S Disease and Frontotemporal Dementia, Crystallized with BA2+ within 5.0Å range: probe atom residue distance (Å) B Occ B:K104 b:25.4 occ:1.00 OP1 B:G17 2.8 16.2 1.0 O3' B:C16 3.5 17.0 1.0 P B:G17 3.8 17.4 1.0 HO2' B:C16 4.3 22.5 1.0 H5' B:G17 4.3 16.4 1.0 H5'' B:G17 4.4 16.4 1.0 O B:HOH215 4.6 30.4 1.0 H4' B:C16 4.7 19.8 1.0 C5' B:G17 4.7 13.7 1.0 O B:HOH220 4.7 27.5 1.0 C3' B:C16 4.8 17.0 1.0 O5' B:G17 4.8 12.7 1.0 O2' B:C16 4.9 18.7 1.0 OP2 B:G17 4.9 17.0 1.0

D.W.Dodd, D.R.Tomchick, D.R.Corey, K.T.Gagnon. Pathogenic C9ORF72 Antisense Repeat Rna Forms A Double Helix with Tandem C:C Mismatches. Biochemistry V. 55 1283 2016.
ISSN: ISSN 0006-2960
PubMed: 26878348
DOI: 10.1021/ACS.BIOCHEM.6B00136