Potassium in PDB 5ec2: Kcsa with V76ESTER+G77DA Mutations

The structure of Kcsa with V76ESTER+G77DA Mutations, PDB code: 5ec2 was solved by K.Matulef, F.I.Valiyaveetil, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	36.50 / 2.30
Space group	I 4
Cell size a, b, c (Å), α, β, γ (°)	154.870, 154.870, 75.703, 90.00, 90.00, 90.00
R / Rfree (%)	23 / 25.9

The binding sites of Potassium atom in the Kcsa with V76ESTER+G77DA Mutations (pdb code 5ec2). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 6 binding sites of Potassium where determined in the Kcsa with V76ESTER+G77DA Mutations, PDB code: 5ec2:
Jump to Potassium binding site number: 1; 2; 3; 4; 5; 6;

Potassium binding site 1 out of 6 in the Kcsa with V76ESTER+G77DA Mutations


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Kcsa with V76ESTER+G77DA Mutations within 5.0Å range: probe atom residue distance (Å) B Occ C:K1002 b:37.9 occ:0.25 OG1 C:THR75 3.0 26.1 1.0 O C:THR75 3.1 30.1 1.0 K C:K1003 3.5 47.3 0.2 CB C:THR75 3.6 24.8 1.0 C C:THR75 3.9 29.6 1.0 CA C:THR75 4.4 27.9 1.0 CG2 C:THR75 4.8 28.3 1.0 O C:THR74 4.9 21.0 1.0 OE C:LHV76 4.9 24.8 1.0

Potassium binding site 2 out of 6 in the Kcsa with V76ESTER+G77DA Mutations


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Kcsa with V76ESTER+G77DA Mutations within 5.0Å range: probe atom residue distance (Å) B Occ C:K1003 b:47.3 occ:0.25 O C:THR75 2.8 30.1 1.0 K C:K1004 2.8 26.4 0.2 O C:LHV76 3.0 23.4 1.0 K C:K1002 3.5 37.9 0.2 C C:LHV76 3.7 27.9 1.0 C C:THR75 3.9 29.6 1.0 CA C:LHV76 4.1 25.7 1.0 OE C:LHV76 4.5 24.8 1.0 N C:DAL77 4.7 28.4 1.0 O C:DAL77 4.9 26.6 1.0

Potassium binding site 3 out of 6 in the Kcsa with V76ESTER+G77DA Mutations


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Kcsa with V76ESTER+G77DA Mutations within 5.0Å range: probe atom residue distance (Å) B Occ C:K1004 b:26.4 occ:0.25 K C:K1003 2.8 47.3 0.2 O C:LHV76 2.9 23.4 1.0 O C:DAL77 2.9 26.6 1.0 K C:K1005 3.5 26.7 0.2 C C:DAL77 3.8 30.3 1.0 C C:LHV76 4.1 27.9 1.0 CA C:DAL77 4.3 29.2 1.0 N C:DAL77 4.7 28.4 1.0 N C:TYR78 4.9 19.2 1.0 O C:THR75 5.0 30.1 1.0

Potassium binding site 4 out of 6 in the Kcsa with V76ESTER+G77DA Mutations


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Kcsa with V76ESTER+G77DA Mutations within 5.0Å range: probe atom residue distance (Å) B Occ C:K1005 b:26.7 occ:0.25 O C:TYR78 3.0 22.1 1.0 O C:DAL77 3.1 26.6 1.0 K C:K1004 3.5 26.4 0.2 C C:TYR78 3.7 24.3 1.0 C C:DAL77 4.3 30.3 1.0 CA C:TYR78 4.4 27.8 1.0 N C:GLY79 4.4 24.2 1.0 CA C:GLY79 4.6 20.9 1.0 N C:TYR78 4.8 19.2 1.0 K C:K1007 4.9 84.2 0.2

Potassium binding site 5 out of 6 in the Kcsa with V76ESTER+G77DA Mutations


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 5 of Kcsa with V76ESTER+G77DA Mutations within 5.0Å range: probe atom residue distance (Å) B Occ C:K1006 b:47.1 occ:0.25 O C:HOH1118 3.3 30.0 1.0 O C:HOH1114 4.4 30.0 1.0

Potassium binding site 6 out of 6 in the Kcsa with V76ESTER+G77DA Mutations


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 6 of Kcsa with V76ESTER+G77DA Mutations within 5.0Å range: probe atom residue distance (Å) B Occ C:K1007 b:84.2 occ:0.25 O C:HOH1117 2.8 30.0 1.0 O C:TYR78 4.6 22.1 1.0 O C:GLY79 4.9 28.2 1.0 K C:K1005 4.9 26.7 0.2

K.Matulef, A.W.Annen, J.C.Nix, F.I.Valiyaveetil. Individual Ion Binding Sites in the K(+) Channel Play Distinct Roles in C-Type Inactivation and in Recovery From Inactivation. Structure V. 24 750 2016.
ISSN: ISSN 0969-2126
PubMed: 27150040
DOI: 10.1016/J.STR.2016.02.021