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Atomistry » Potassium » PDB 5dkp-5f0g » 5drt » |
Potassium in PDB 5drt: Crystal Structure of DOT1L in Complex with Inhibitor CPD2 [2-(2-(5- ((2-Chlorophenoxy)Methyl)-1H-Tetrazol-1-Yl)Acetyl)-N-(4- Chlorophenyl)Hydrazinecarboxamide]Enzymatic activity of Crystal Structure of DOT1L in Complex with Inhibitor CPD2 [2-(2-(5- ((2-Chlorophenoxy)Methyl)-1H-Tetrazol-1-Yl)Acetyl)-N-(4- Chlorophenyl)Hydrazinecarboxamide]
All present enzymatic activity of Crystal Structure of DOT1L in Complex with Inhibitor CPD2 [2-(2-(5- ((2-Chlorophenoxy)Methyl)-1H-Tetrazol-1-Yl)Acetyl)-N-(4- Chlorophenyl)Hydrazinecarboxamide]:
2.1.1.43; Protein crystallography data
The structure of Crystal Structure of DOT1L in Complex with Inhibitor CPD2 [2-(2-(5- ((2-Chlorophenoxy)Methyl)-1H-Tetrazol-1-Yl)Acetyl)-N-(4- Chlorophenyl)Hydrazinecarboxamide], PDB code: 5drt
was solved by
C.Scheufler,
C.Gaul,
C.Be,
H.Moebitz,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5drt:
The structure of Crystal Structure of DOT1L in Complex with Inhibitor CPD2 [2-(2-(5- ((2-Chlorophenoxy)Methyl)-1H-Tetrazol-1-Yl)Acetyl)-N-(4- Chlorophenyl)Hydrazinecarboxamide] also contains other interesting chemical elements:
Potassium Binding Sites:
The binding sites of Potassium atom in the Crystal Structure of DOT1L in Complex with Inhibitor CPD2 [2-(2-(5- ((2-Chlorophenoxy)Methyl)-1H-Tetrazol-1-Yl)Acetyl)-N-(4- Chlorophenyl)Hydrazinecarboxamide]
(pdb code 5drt). This binding sites where shown within
5.0 Angstroms radius around Potassium atom.
In total only one binding site of Potassium was determined in the Crystal Structure of DOT1L in Complex with Inhibitor CPD2 [2-(2-(5- ((2-Chlorophenoxy)Methyl)-1H-Tetrazol-1-Yl)Acetyl)-N-(4- Chlorophenyl)Hydrazinecarboxamide], PDB code: 5drt: Potassium binding site 1 out of 1 in 5drtGo back to Potassium Binding Sites List in 5drt
Potassium binding site 1 out
of 1 in the Crystal Structure of DOT1L in Complex with Inhibitor CPD2 [2-(2-(5- ((2-Chlorophenoxy)Methyl)-1H-Tetrazol-1-Yl)Acetyl)-N-(4- Chlorophenyl)Hydrazinecarboxamide]
Mono view Stereo pair view
Reference:
C.Chen,
H.Zhu,
F.Stauffer,
G.Caravatti,
S.Vollmer,
R.Machauer,
P.Holzer,
H.Mobitz,
C.Scheufler,
M.Klumpp,
R.Tiedt,
K.S.Beyer,
K.Calkins,
D.Guthy,
M.Kiffe,
J.Zhang,
C.Gaul.
Discovery of Novel DOT1L Inhibitors Through A Structure-Based Fragmentation Approach. Acs Med.Chem.Lett. V. 7 735 2016.
Page generated: Sun Dec 13 23:56:32 2020
ISSN: ISSN 1948-5875 PubMed: 27563395 DOI: 10.1021/ACSMEDCHEMLETT.6B00167 |
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