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Potassium in PDB 4zqo: Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase From Mycobacterium Tuberculosis in the Complex with Imp and the Inhibitor Q67

Enzymatic activity of Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase From Mycobacterium Tuberculosis in the Complex with Imp and the Inhibitor Q67

All present enzymatic activity of Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase From Mycobacterium Tuberculosis in the Complex with Imp and the Inhibitor Q67:
1.1.1.205;

Protein crystallography data

The structure of Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase From Mycobacterium Tuberculosis in the Complex with Imp and the Inhibitor Q67, PDB code: 4zqo was solved by Y.Kim, M.Makowska-Grzyska, M.Gu, M.Kavitha, L.Hedstrom, W.F.Anderson, A.Joachimiak, Center For Structural Genomics Of Infectious Diseases(Csgid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.47 / 1.76
Space group I 4
Cell size a, b, c (Å), α, β, γ (°) 88.252, 88.252, 84.268, 90.00, 90.00, 90.00
R / Rfree (%) 15.3 / 17.9

Other elements in 4zqo:

The structure of Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase From Mycobacterium Tuberculosis in the Complex with Imp and the Inhibitor Q67 also contains other interesting chemical elements:

Chlorine (Cl) 2 atoms

Potassium Binding Sites:

The binding sites of Potassium atom in the Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase From Mycobacterium Tuberculosis in the Complex with Imp and the Inhibitor Q67 (pdb code 4zqo). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total only one binding site of Potassium was determined in the Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase From Mycobacterium Tuberculosis in the Complex with Imp and the Inhibitor Q67, PDB code: 4zqo:

Potassium binding site 1 out of 1 in 4zqo

Go back to Potassium Binding Sites List in 4zqo
Potassium binding site 1 out of 1 in the Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase From Mycobacterium Tuberculosis in the Complex with Imp and the Inhibitor Q67


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase From Mycobacterium Tuberculosis in the Complex with Imp and the Inhibitor Q67 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K603

b:24.5
occ:1.00
O A:GLY338 2.7 21.5 1.0
O A:CYS341 2.8 21.5 1.0
O A:GLY336 2.8 23.1 1.0
O A:HOH762 3.3 24.4 1.0
C A:CYS341 3.7 21.6 1.0
C A:GLY338 3.8 20.5 1.0
CB A:CYS341 3.8 21.4 1.0
C A:PRO337 3.9 20.6 1.0
C A:GLY336 3.9 24.8 1.0
N A:GLY338 4.0 19.6 1.0
O A:PRO337 4.0 22.1 1.0
CA A:CYS341 4.1 21.3 1.0
N A:CYS341 4.2 19.2 1.0
SG A:CYS341 4.3 26.4 1.0
CA A:PRO337 4.4 20.6 1.0
CA A:GLY338 4.5 20.3 1.0
N A:PRO337 4.7 23.4 1.0
N A:THR342 4.8 21.4 1.0
N A:SER339 4.9 16.5 1.0
CA A:GLY336 4.9 23.8 1.0
C A:SER339 5.0 21.5 1.0

Reference:

M.Makowska-Grzyska, Y.Kim, S.K.Gorla, Y.Wei, K.Mandapati, M.Zhang, N.Maltseva, G.Modi, H.I.Boshoff, M.Gu, C.Aldrich, G.D.Cuny, L.Hedstrom, A.Joachimiak. Mycobacterium Tuberculosis Impdh in Complexes with Substrates, Products and Antitubercular Compounds. Plos One V. 10 38976 2015.
ISSN: ESSN 1932-6203
PubMed: 26440283
DOI: 10.1371/JOURNAL.PONE.0138976
Page generated: Mon Aug 12 12:47:47 2024

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