Atomistry » Potassium » PDB 4wpz-4xs4 » 4xdl
Atomistry »
  Potassium »
    PDB 4wpz-4xs4 »
      4xdl »

Potassium in PDB 4xdl: Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) in Complex with A Brominated Fluoxetine Derivative.

Protein crystallography data

The structure of Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) in Complex with A Brominated Fluoxetine Derivative., PDB code: 4xdl was solved by A.Mackenzie, A.C.W.Pike, Y.Y.Dong, S.Mukhopadhyay, G.F.Ruda, P.E.Brennan, C.H.Arrowsmith, A.M.Edwards, C.Bountra, N.A.Burgess-Brown, E.P.Carpenter, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 35.00 / 3.50
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 101.710, 109.840, 166.740, 90.00, 90.00, 90.00
R / Rfree (%) 23.5 / 26.3

Other elements in 4xdl:

The structure of Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) in Complex with A Brominated Fluoxetine Derivative. also contains other interesting chemical elements:

Fluorine (F) 12 atoms
Cadmium (Cd) 2 atoms
Bromine (Br) 4 atoms

Potassium Binding Sites:

The binding sites of Potassium atom in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) in Complex with A Brominated Fluoxetine Derivative. (pdb code 4xdl). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 6 binding sites of Potassium where determined in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) in Complex with A Brominated Fluoxetine Derivative., PDB code: 4xdl:
Jump to Potassium binding site number: 1; 2; 3; 4; 5; 6;

Potassium binding site 1 out of 6 in 4xdl

Go back to Potassium Binding Sites List in 4xdl
Potassium binding site 1 out of 6 in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) in Complex with A Brominated Fluoxetine Derivative.


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) in Complex with A Brominated Fluoxetine Derivative. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K601

b:0.5
occ:1.00
 O B:GLY283 2.3 0.7 1.0
O A:GLY283 2.3 0.5 1.0
O B:GLY174 2.8 0.3 1.0
O A:GLY174 2.8 0.8 1.0
O A:ILE173 2.9 0.1 1.0
O A:VAL282 3.0 0.2 1.0
O B:VAL282 3.0 0.1 1.0
O B:ILE173 3.0 96.8 1.0
C B:GLY283 3.4 0.6 1.0
C A:GLY283 3.4 0.4 1.0
K B:K401 3.4 0.9 1.0
C A:GLY174 3.5 0.1 1.0
C B:GLY174 3.6 0.1 1.0
O B:TYR175 3.9 0.2 1.0
O A:TYR175 4.0 0.3 1.0
C A:ILE173 4.0 0.9 1.0
CA B:GLY283 4.1 0.2 1.0
C A:VAL282 4.1 0.3 1.0
CA A:GLY283 4.1 0.8 1.0
C B:VAL282 4.1 0.5 1.0
CA A:GLY174 4.1 0.6 1.0
C B:ILE173 4.2 97.4 1.0
N A:TYR175 4.2 0.7 1.0
CA B:GLY174 4.3 95.1 1.0
N B:TYR175 4.3 98.8 1.0
C B:TYR175 4.4 0.8 1.0
N B:PHE284 4.4 0.5 1.0
C A:TYR175 4.4 0.4 1.0
N A:PHE284 4.4 99.7 1.0
CA A:TYR175 4.5 0.8 1.0
N A:GLY174 4.5 0.5 1.0
N B:GLY283 4.5 0.7 1.0
N A:GLY283 4.5 0.2 1.0
CA B:TYR175 4.5 99.9 1.0
N B:GLY174 4.7 94.9 1.0
CA B:PHE284 4.7 0.4 1.0
CA A:PHE284 4.7 99.1 1.0

Potassium binding site 2 out of 6 in 4xdl

Go back to Potassium Binding Sites List in 4xdl
Potassium binding site 2 out of 6 in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) in Complex with A Brominated Fluoxetine Derivative.


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) in Complex with A Brominated Fluoxetine Derivative. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K602

b:0.3
occ:1.00
 O B:THR281 2.7 0.5 1.0
OG1 A:THR172 2.8 0.2 1.0
O A:THR172 2.8 0.7 1.0
O B:THR172 2.8 98.8 1.0
OG1 B:THR172 2.9 98.8 1.0
OG1 B:THR281 2.9 0.6 1.0
O A:THR281 3.0 0.2 1.0
OG1 A:THR281 3.0 0.7 1.0
CB A:THR172 3.4 0.3 1.0
CB B:THR281 3.5 0.9 1.0
K B:K401 3.6 0.9 1.0
CB A:THR281 3.6 0.8 1.0
C B:THR281 3.7 0.5 1.0
CB B:THR172 3.7 98.7 1.0
C A:THR172 3.7 0.7 1.0
C B:THR172 3.8 98.7 1.0
C A:THR281 3.9 0.9 1.0
CA A:THR172 4.2 0.9 1.0
CA B:THR281 4.2 0.8 1.0
CA B:THR172 4.4 94.5 1.0
CA A:THR281 4.4 0.8 1.0
CG2 A:THR172 4.6 0.0 1.0
N B:ILE173 4.8 94.2 1.0
CG2 B:THR281 4.8 0.3 1.0
N B:VAL282 4.8 0.6 1.0
N A:ILE173 4.9 0.6 1.0
CG2 A:THR281 4.9 0.8 1.0
O B:THR171 4.9 0.5 1.0
O B:THR280 5.0 0.8 1.0
CG2 B:THR172 5.0 96.1 1.0

Potassium binding site 3 out of 6 in 4xdl

Go back to Potassium Binding Sites List in 4xdl
Potassium binding site 3 out of 6 in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) in Complex with A Brominated Fluoxetine Derivative.


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) in Complex with A Brominated Fluoxetine Derivative. within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K401

b:0.9
occ:1.00
 O A:THR281 2.7 0.2 1.0
O B:VAL282 2.7 0.1 1.0
O B:ILE173 2.8 96.8 1.0
O A:VAL282 2.8 0.2 1.0
O A:THR172 2.8 0.7 1.0
O B:THR172 2.8 98.8 1.0
O B:THR281 2.8 0.5 1.0
O A:ILE173 2.9 0.1 1.0
K A:K601 3.4 0.5 1.0
C B:ILE173 3.4 97.4 1.0
C B:VAL282 3.5 0.5 1.0
C A:VAL282 3.6 0.3 1.0
C A:ILE173 3.6 0.9 1.0
K A:K602 3.6 0.3 1.0
C A:THR281 3.8 0.9 1.0
C B:THR172 3.8 98.7 1.0
C A:THR172 3.9 0.7 1.0
CA B:ILE173 3.9 93.2 1.0
C B:THR281 3.9 0.5 1.0
CA A:ILE173 4.0 0.2 1.0
CA A:VAL282 4.0 98.6 1.0
CA B:VAL282 4.1 0.3 1.0
N B:ILE173 4.3 94.2 1.0
N A:VAL282 4.4 0.8 1.0
N A:ILE173 4.4 0.6 1.0
N B:GLY283 4.4 0.7 1.0
N B:GLY174 4.4 94.9 1.0
N B:VAL282 4.4 0.6 1.0
N A:GLY174 4.5 0.5 1.0
N A:GLY283 4.5 0.2 1.0
O B:GLY283 4.7 0.7 1.0
CA B:GLY283 4.8 0.2 1.0
O A:GLY283 4.8 0.5 1.0
CA A:GLY283 4.9 0.8 1.0
CA A:GLY174 4.9 0.6 1.0
CA B:GLY174 4.9 95.1 1.0
CA A:THR281 5.0 0.8 1.0

Potassium binding site 4 out of 6 in 4xdl

Go back to Potassium Binding Sites List in 4xdl
Potassium binding site 4 out of 6 in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) in Complex with A Brominated Fluoxetine Derivative.


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) in Complex with A Brominated Fluoxetine Derivative. within 5.0Å range:
probe atom residue distance (Å) B Occ
C:K601

b:0.8
occ:1.00
 O C:GLY283 2.3 0.3 1.0
O D:GLY283 2.4 0.5 1.0
O D:GLY174 2.8 0.3 1.0
O C:GLY174 2.8 0.1 1.0
O C:ILE173 2.8 0.2 1.0
O D:ILE173 2.9 0.4 1.0
O C:VAL282 2.9 0.4 1.0
O D:VAL282 3.0 0.5 1.0
C C:GLY283 3.4 0.0 1.0
C D:GLY174 3.4 0.1 1.0
C C:GLY174 3.4 0.9 1.0
K C:K602 3.4 0.1 1.0
C D:GLY283 3.5 0.6 1.0
O C:TYR175 3.9 0.1 1.0
C C:ILE173 4.0 0.3 1.0
O D:TYR175 4.0 0.4 1.0
C C:VAL282 4.0 0.3 1.0
C D:ILE173 4.1 0.3 1.0
CA C:GLY283 4.1 0.8 1.0
C D:VAL282 4.1 0.1 1.0
CA D:GLY283 4.1 0.3 1.0
N C:TYR175 4.2 0.3 1.0
CA D:GLY174 4.2 0.1 1.0
CA C:GLY174 4.2 0.3 1.0
N D:TYR175 4.2 0.8 1.0
C C:TYR175 4.4 0.2 1.0
C D:TYR175 4.4 0.1 1.0
CA C:TYR175 4.4 0.1 1.0
N C:PHE284 4.4 0.5 1.0
CA D:TYR175 4.5 0.6 1.0
N C:GLY283 4.5 0.0 1.0
N C:GLY174 4.5 0.8 1.0
N D:PHE284 4.5 0.6 1.0
N D:GLY174 4.5 0.8 1.0
N D:GLY283 4.5 0.8 1.0
CA C:PHE284 4.7 0.9 1.0
CA D:PHE284 4.8 0.6 1.0

Potassium binding site 5 out of 6 in 4xdl

Go back to Potassium Binding Sites List in 4xdl
Potassium binding site 5 out of 6 in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) in Complex with A Brominated Fluoxetine Derivative.


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 5 of Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) in Complex with A Brominated Fluoxetine Derivative. within 5.0Å range:
probe atom residue distance (Å) B Occ
C:K602

b:0.1
occ:1.00
 O D:THR281 2.6 0.7 1.0
O C:THR281 2.7 0.6 1.0
O C:ILE173 2.7 0.2 1.0
O C:THR172 2.7 0.9 1.0
O D:ILE173 2.8 0.4 1.0
O C:VAL282 2.8 0.4 1.0
O D:VAL282 2.8 0.5 1.0
O D:THR172 2.9 1.0 1.0
K C:K603 3.4 0.5 1.0
C C:ILE173 3.4 0.3 1.0
K C:K601 3.4 0.8 1.0
C D:ILE173 3.5 0.3 1.0
C C:VAL282 3.5 0.3 1.0
C D:VAL282 3.6 0.1 1.0
C C:THR281 3.8 0.7 1.0
C D:THR281 3.8 0.5 1.0
C C:THR172 3.8 0.1 1.0
CA C:ILE173 3.8 0.1 1.0
C D:THR172 3.9 0.4 1.0
CA D:ILE173 4.0 0.6 1.0
CA C:VAL282 4.0 0.4 1.0
CA D:VAL282 4.1 0.6 1.0
N C:ILE173 4.3 0.6 1.0
N C:VAL282 4.3 0.0 1.0
N D:VAL282 4.4 0.4 1.0
N D:ILE173 4.4 0.6 1.0
N C:GLY174 4.4 0.8 1.0
N D:GLY174 4.4 0.8 1.0
N C:GLY283 4.5 0.0 1.0
N D:GLY283 4.5 0.8 1.0
O C:GLY283 4.8 0.3 1.0
O D:GLY283 4.9 0.5 1.0
CA C:GLY283 4.9 0.8 1.0
CA D:GLY174 4.9 0.1 1.0
CA C:GLY174 4.9 0.3 1.0
CA C:THR281 4.9 0.7 1.0
CA D:THR281 5.0 0.8 1.0
CA D:GLY283 5.0 0.3 1.0

Potassium binding site 6 out of 6 in 4xdl

Go back to Potassium Binding Sites List in 4xdl
Potassium binding site 6 out of 6 in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) in Complex with A Brominated Fluoxetine Derivative.


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 6 of Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK2 (K2P10.1) in Complex with A Brominated Fluoxetine Derivative. within 5.0Å range:
probe atom residue distance (Å) B Occ
C:K603

b:0.5
occ:1.00
 O C:THR172 2.4 0.9 1.0
OG1 C:THR172 2.6 0.8 1.0
OG1 D:THR281 2.8 0.1 1.0
O D:THR281 2.8 0.7 1.0
O C:THR281 2.9 0.6 1.0
O D:THR172 2.9 1.0 1.0
OG1 C:THR281 3.1 0.3 1.0
CB C:THR172 3.3 0.3 1.0
OG1 D:THR172 3.4 0.3 1.0
K C:K602 3.4 0.1 1.0
C C:THR172 3.4 0.1 1.0
CB D:THR281 3.4 0.5 1.0
CB C:THR281 3.5 0.2 1.0
C D:THR281 3.6 0.5 1.0
C C:THR281 3.9 0.7 1.0
CA C:THR172 4.0 0.3 1.0
C D:THR172 4.0 0.4 1.0
CB D:THR172 4.0 0.8 1.0
CA D:THR281 4.2 0.8 1.0
CA C:THR281 4.3 0.7 1.0
N C:ILE173 4.5 0.6 1.0
CG2 C:THR172 4.6 0.7 1.0
CA D:THR172 4.7 0.9 1.0
N D:VAL282 4.7 0.4 1.0
CG2 C:THR281 4.7 0.6 1.0
CG2 D:THR281 4.7 0.1 1.0
O C:THR171 4.7 0.0 1.0
O D:THR280 4.8 0.9 1.0
CA C:ILE173 4.9 0.1 1.0
N D:ILE173 5.0 0.6 1.0
N C:VAL282 5.0 0.0 1.0

Reference:

A.C.W.Pike, A.Mackenzie, C.Mcclenaghan, P.Aryal, L.Dong, A.Quigley, M.Grieben, S.Goubin, S.Mukhopadhyay, G.F.Ruda, M.V.Clausen, L.Cao, P.E.Brennan, N.A.Burgess-Brown, M.S.P.Sansom, S.J.Tucker, E.P.Carpenter. K2P Channel Gating Mechanisms Revealed By Structures of Trek-2 and A Complex with Prozac Science V. 347 2015.
ISSN: ESSN 1095-9203
DOI: 10.1126/SCIENCE.1261512
Page generated: Sun Dec 13 23:51:54 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy