Potassium in PDB 4x3z: Inosine 5'-Monophosphate Dehydrogenase From Vibrio Cholerae, Deletion Mutant, in Complex with Xmp and Nad

All present enzymatic activity of Inosine 5'-Monophosphate Dehydrogenase From Vibrio Cholerae, Deletion Mutant, in Complex with Xmp and Nad:
1.1.1.205;

The structure of Inosine 5'-Monophosphate Dehydrogenase From Vibrio Cholerae, Deletion Mutant, in Complex with Xmp and Nad, PDB code: 4x3z was solved by J.Osipiuk, N.Maltseva, Y.Kim, R.Mulligan, M.Makowska-Grzyska, M.Gu, W.F.Anderson, A.Joachimiak, Center For Structural Genomics Ofinfectious Diseases (Csgid), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	44.20 / 1.62
Space group	P 4 21 2
Cell size a, b, c (Å), α, β, γ (°)	91.262, 91.262, 171.214, 90.00, 90.00, 90.00
R / Rfree (%)	15.2 / 18.2

The binding sites of Potassium atom in the Inosine 5'-Monophosphate Dehydrogenase From Vibrio Cholerae, Deletion Mutant, in Complex with Xmp and Nad (pdb code 4x3z). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 2 binding sites of Potassium where determined in the Inosine 5'-Monophosphate Dehydrogenase From Vibrio Cholerae, Deletion Mutant, in Complex with Xmp and Nad, PDB code: 4x3z:
Jump to Potassium binding site number: 1; 2;

Potassium binding site 1 out of 2 in the Inosine 5'-Monophosphate Dehydrogenase From Vibrio Cholerae, Deletion Mutant, in Complex with Xmp and Nad


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Inosine 5'-Monophosphate Dehydrogenase From Vibrio Cholerae, Deletion Mutant, in Complex with Xmp and Nad within 5.0Å range: probe atom residue distance (Å) B Occ A:K502 b:15.5 occ:0.65 O A:GLU471 2.7 22.8 1.0 O A:HIS473 2.7 23.5 1.0 O A:SER472 2.9 22.5 1.0 C A:SER472 3.4 25.4 1.0 C A:HIS473 3.6 25.4 1.0 C A:GLU471 3.8 23.6 1.0 CA A:SER472 4.0 22.4 1.0 CD2 A:HIS475 4.0 23.4 1.0 N A:HIS473 4.1 22.4 1.0 NE2 A:HIS475 4.3 24.2 1.0 N A:SER472 4.3 24.1 1.0 N A:VAL474 4.3 23.6 1.0 CA A:HIS473 4.4 23.8 1.0 CA A:VAL474 4.6 26.6 1.0 CA A:GLU471 5.0 23.5 1.0

Potassium binding site 2 out of 2 in the Inosine 5'-Monophosphate Dehydrogenase From Vibrio Cholerae, Deletion Mutant, in Complex with Xmp and Nad


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Inosine 5'-Monophosphate Dehydrogenase From Vibrio Cholerae, Deletion Mutant, in Complex with Xmp and Nad within 5.0Å range: probe atom residue distance (Å) B Occ B:K502 b:12.9 occ:0.70 O B:GLY304 2.6 19.1 1.0 O B:CYS307 2.7 21.4 1.0 O B:GLY302 2.9 18.1 1.0 O B:HOH633 3.4 17.1 1.0 SG B:CYS307 3.5 49.1 1.0 C B:CYS307 3.7 21.3 1.0 C B:GLY304 3.8 17.3 1.0 C B:PRO303 3.9 17.0 1.0 O B:PRO303 4.0 17.1 1.0 N B:GLY304 4.1 17.4 1.0 C B:GLY302 4.1 18.3 1.0 N B:CYS307 4.2 23.8 1.0 CA B:CYS307 4.3 25.4 1.0 CB B:CYS307 4.4 31.5 1.0 CA B:PRO303 4.4 17.3 1.0 CA B:GLY304 4.5 17.8 1.0 O B:SER305 4.6 19.9 1.0 N B:THR308 4.7 18.8 1.0 N B:SER305 4.7 17.2 1.0 C B:SER305 4.8 19.6 1.0 N B:PRO303 4.8 17.3 1.0 CA B:SER305 4.9 17.7 1.0

J.Osipiuk, N.Maltseva, Y.Kim, R.Mulligan, M.Makowska-Grzyska, M.Gu, W.F.Anderson, A.Joachimiak, Center For Structural Genomics Of Infectious Diseases(Csgid). Inosine 5'-Monophosphate Dehydrogenase From Vibrio Cholerae, Deletion Mutant, in Complex with Xmp and Nad To Be Published.