Potassium in PDB 4uuj: Potassium Channel Kcsa-Fab with Tetrahexylammonium

The structure of Potassium Channel Kcsa-Fab with Tetrahexylammonium, PDB code: 4uuj was solved by M.J.Lenaeus, D.Burdette, T.Wagner, P.J.Focia, A.Gross, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	28.64 / 2.40
Space group	I 4
Cell size a, b, c (Å), α, β, γ (°)	154.615, 154.615, 75.953, 90.00, 90.00, 90.00
R / Rfree (%)	19.148 / 24.823

The structure of Potassium Channel Kcsa-Fab with Tetrahexylammonium also contains other interesting chemical elements:

Cobalt

(Co)

1 atom

The binding sites of Potassium atom in the Potassium Channel Kcsa-Fab with Tetrahexylammonium (pdb code 4uuj). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 4 binding sites of Potassium where determined in the Potassium Channel Kcsa-Fab with Tetrahexylammonium, PDB code: 4uuj:
Jump to Potassium binding site number: 1; 2; 3; 4;

Potassium binding site 1 out of 4 in the Potassium Channel Kcsa-Fab with Tetrahexylammonium


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Potassium Channel Kcsa-Fab with Tetrahexylammonium within 5.0Å range: probe atom residue distance (Å) B Occ C:K1125 b:39.4 occ:0.25 O C:TYR78 2.9 38.1 1.0 O C:GLY77 3.2 44.0 1.0 K C:K1126 3.4 35.7 0.2 C C:TYR78 3.6 38.3 1.0 CA C:TYR78 4.2 37.5 1.0 N C:GLY79 4.2 37.7 1.0 C C:GLY77 4.3 40.4 1.0 CA C:GLY79 4.5 32.6 1.0 CAL C:XA71131 4.5 75.9 0.1 CAN C:XA71131 4.6 74.9 0.1 CAN C:XA71131 4.7 93.7 0.1 N C:TYR78 4.8 39.3 1.0 CAL C:XA71131 4.9 94.5 0.1

Potassium binding site 2 out of 4 in the Potassium Channel Kcsa-Fab with Tetrahexylammonium


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Potassium Channel Kcsa-Fab with Tetrahexylammonium within 5.0Å range: probe atom residue distance (Å) B Occ C:K1126 b:35.7 occ:0.25 O C:GLY77 2.7 44.0 1.0 O C:VAL76 2.9 39.4 1.0 K C:K1127 3.2 36.7 0.2 K C:K1125 3.4 39.4 0.2 C C:GLY77 3.6 40.4 1.0 C C:VAL76 4.1 40.6 1.0 CA C:GLY77 4.1 38.5 1.0 N C:GLY77 4.6 40.9 1.0 N C:TYR78 4.6 39.3 1.0 CA C:TYR78 4.9 37.5 1.0

Potassium binding site 3 out of 4 in the Potassium Channel Kcsa-Fab with Tetrahexylammonium


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Potassium Channel Kcsa-Fab with Tetrahexylammonium within 5.0Å range: probe atom residue distance (Å) B Occ C:K1127 b:36.7 occ:0.25 O C:THR75 2.7 41.1 1.0 O C:VAL76 3.0 39.4 1.0 K C:K1126 3.2 35.7 0.2 K C:K1128 3.3 44.8 0.2 C C:VAL76 3.7 40.6 1.0 C C:THR75 3.9 41.0 1.0 CA C:VAL76 4.0 40.7 1.0 N C:VAL76 4.4 43.4 1.0 N C:GLY77 4.7 40.9 1.0 OG1 C:THR75 5.0 39.5 1.0

Potassium binding site 4 out of 4 in the Potassium Channel Kcsa-Fab with Tetrahexylammonium


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Potassium Channel Kcsa-Fab with Tetrahexylammonium within 5.0Å range: probe atom residue distance (Å) B Occ C:K1128 b:44.8 occ:0.25 OG1 C:THR75 2.8 39.5 1.0 O C:THR75 3.1 41.1 1.0 K C:K1127 3.3 36.7 0.2 CB C:THR75 3.7 45.5 1.0 C C:THR75 3.9 41.0 1.0 CAF C:XA71132 4.2 11.5 0.1 CAN C:XA71132 4.3 11.7 0.1 CA C:THR75 4.4 41.5 1.0 CAL C:XA71132 4.5 36.9 0.1 CAT C:XA71132 4.6 37.0 0.1 N C:VAL76 4.8 43.4 1.0 O C:THR74 4.8 41.0 1.0 NAM C:XA71132 4.9 11.6 0.1 CG2 C:THR75 4.9 49.7 1.0

M.J.Lenaeus, D.Burdette, T.Wagner, P.J.Focia, A.Gross. Structures of Kcsa in Complex with Symmetrical Quaternary Ammonium Compounds Reveal A Hydrophobic Binding Site. Biochemistry V. 53 5365 2014.
ISSN: ISSN 0006-2960
PubMed: 25093676
DOI: 10.1021/BI500525S