Potassium in PDB 4u76: Hsmetap (F309M) Holo Form

All present enzymatic activity of Hsmetap (F309M) Holo Form:
3.4.11.18;

The structure of Hsmetap (F309M) Holo Form, PDB code: 4u76 was solved by T.Arya, A.Addlagatta, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	18.72 / 1.87
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	47.067, 77.469, 46.990, 90.00, 92.43, 90.00
R / Rfree (%)	17.7 / 22.3

The structure of Hsmetap (F309M) Holo Form also contains other interesting chemical elements:

Cobalt

(Co)

2 atoms

The binding sites of Potassium atom in the Hsmetap (F309M) Holo Form (pdb code 4u76). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total only one binding site of Potassium was determined in the Hsmetap (F309M) Holo Form, PDB code: 4u76:

Potassium binding site 1 out of 1 in the Hsmetap (F309M) Holo Form


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Hsmetap (F309M) Holo Form within 5.0Å range: probe atom residue distance (Å) B Occ A:K502 b:38.4 occ:1.00 O A:HOH780 2.2 57.9 1.0 O A:VAL209 2.4 22.9 1.0 O A:SER363 2.5 27.1 1.0 O A:HOH628 2.7 29.7 1.0 O A:ASN207 2.8 27.2 1.0 O A:SER205 3.2 25.6 1.0 C A:VAL209 3.5 22.2 1.0 C A:SER363 3.6 24.5 1.0 C A:ASN207 3.6 24.5 1.0 N A:ASN207 3.6 26.1 1.0 C A:VAL206 3.8 23.5 1.0 C A:SER205 3.8 22.7 1.0 CA A:ASN207 4.0 23.5 1.0 O A:VAL206 4.0 25.5 1.0 O A:HOH643 4.2 21.8 1.0 N A:VAL206 4.2 26.4 1.0 N A:SER363 4.3 31.0 1.0 N A:VAL209 4.3 27.1 1.0 CB A:SER205 4.3 21.0 1.0 CA A:SER363 4.3 28.7 1.0 CA A:VAL206 4.4 26.9 1.0 CA A:VAL209 4.4 23.9 1.0 CB A:SER363 4.5 25.9 1.0 N A:ILE210 4.5 22.5 1.0 CD1 A:ILE225 4.5 35.0 1.0 N A:ALA364 4.5 26.1 1.0 N A:GLU208 4.6 26.4 1.0 CG1 A:ILE225 4.7 33.5 1.0 CA A:SER205 4.7 20.3 1.0 CA A:ALA364 4.7 25.5 1.0 CA A:ILE210 4.7 27.1 1.0 CB A:VAL209 4.8 22.9 1.0 O A:ILE225 4.8 25.8 1.0 C A:GLU208 4.9 25.8 1.0 O A:HOH684 4.9 21.8 1.0

T.Arya, R.Reddi, C.Kishor, R.J.Ganji, S.Bhukya, R.Gumpena, S.Mcgowan, M.Drag, A.Addlagatta. Identification of the Molecular Basis of Inhibitor Selectivity Between the Human and Streptococcal Type I Methionine Aminopeptidases J.Med.Chem. V. 58 2350 2015.
ISSN: ISSN 0022-2623
PubMed: 25699713
DOI: 10.1021/JM501790E