Potassium in PDB 4u75: Hsmetap (F309M) in Complex with Methionine

All present enzymatic activity of Hsmetap (F309M) in Complex with Methionine:
3.4.11.18;

The structure of Hsmetap (F309M) in Complex with Methionine, PDB code: 4u75 was solved by T.Arya, A.Addlagatta, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	17.70 / 1.94
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	47.586, 77.398, 48.658, 90.00, 90.59, 90.00
R / Rfree (%)	16.8 / 21.8

The structure of Hsmetap (F309M) in Complex with Methionine also contains other interesting chemical elements:

Cobalt

(Co)

2 atoms

The binding sites of Potassium atom in the Hsmetap (F309M) in Complex with Methionine (pdb code 4u75). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total only one binding site of Potassium was determined in the Hsmetap (F309M) in Complex with Methionine, PDB code: 4u75:

Potassium binding site 1 out of 1 in the Hsmetap (F309M) in Complex with Methionine


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Hsmetap (F309M) in Complex with Methionine within 5.0Å range: probe atom residue distance (Å) B Occ A:K402 b:43.5 occ:1.00 O A:VAL209 2.6 18.5 1.0 O A:SER363 2.6 15.7 1.0 O A:ASN207 2.9 19.8 1.0 O A:HOH721 3.0 20.3 1.0 O A:SER205 3.3 15.9 1.0 N A:ASN207 3.5 18.5 1.0 C A:ASN207 3.7 18.2 1.0 C A:SER363 3.7 17.1 1.0 C A:VAL206 3.7 15.8 1.0 C A:VAL209 3.8 18.2 1.0 C A:SER205 3.9 15.6 1.0 CA A:ASN207 4.0 19.2 1.0 O A:VAL206 4.1 15.2 1.0 N A:VAL206 4.2 14.3 1.0 N A:VAL209 4.3 17.6 1.0 CB A:SER205 4.3 14.2 1.0 N A:SER363 4.3 17.6 1.0 CA A:VAL206 4.3 17.7 1.0 CA A:SER363 4.4 15.1 1.0 CA A:VAL209 4.5 17.4 1.0 CB A:SER363 4.6 17.2 1.0 CG1 A:ILE225 4.6 21.4 1.0 O A:HOH630 4.6 13.6 1.0 N A:ALA364 4.6 17.8 1.0 CA A:ALA364 4.7 17.7 1.0 CD1 A:ILE225 4.7 20.1 1.0 N A:GLU208 4.7 17.2 1.0 CA A:SER205 4.7 13.9 1.0 CB A:VAL209 4.8 16.3 1.0 N A:ILE210 4.8 18.4 1.0 O A:ILE225 4.8 16.7 1.0 C A:GLU208 4.9 17.2 1.0 O A:HOH579 4.9 16.5 1.0

T.Arya, R.Reddi, C.Kishor, R.J.Ganji, S.Bhukya, R.Gumpena, S.Mcgowan, M.Drag, A.Addlagatta. Identification of the Molecular Basis of Inhibitor Selectivity Between the Human and Streptococcal Type I Methionine Aminopeptidases J.Med.Chem. V. 58 2350 2015.
ISSN: ISSN 0022-2623
PubMed: 25699713
DOI: 10.1021/JM501790E