Potassium in PDB 4twk: Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK1 (K2P2.1)

The structure of Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK1 (K2P2.1), PDB code: 4twk was solved by A.C.W.Pike, Y.Y.Dong, A.Tessitore, S.Goubin, C.Strain-Damerell, S.Mukhopadhyay, K.Kupinska, D.Wang, R.Chalk, G.Berridge, M.Grieben, L.Shrestha, J.H.Ang, A.Mackenzie, A.Quigley, S.R.Bushell, C.A.Shintre, B.Faust, A.Chu, L.Dong, F.Von Delft, C.H.Arrowsmith, A.M.Edwards, C.Bountra, N.A.Burgess-Brown, E.P.Carpenter, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	33.94 / 2.60
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	74.470, 105.975, 128.270, 90.00, 90.00, 90.00
R / Rfree (%)	23.1 / 25.8

The structure of Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK1 (K2P2.1) also contains other interesting chemical elements:

Magnesium

(Mg)

1 atom

The binding sites of Potassium atom in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK1 (K2P2.1) (pdb code 4twk). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 3 binding sites of Potassium where determined in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK1 (K2P2.1), PDB code: 4twk:
Jump to Potassium binding site number: 1; 2; 3;

Potassium binding site 1 out of 3 in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK1 (K2P2.1)


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK1 (K2P2.1) within 5.0Å range: probe atom residue distance (Å) B Occ A:K401 b:64.1 occ:1.00 O B:THR142 2.6 66.3 1.0 OG1 A:THR142 2.7 62.1 1.0 OG1 B:THR251 2.7 58.9 1.0 O A:THR251 2.7 68.9 1.0 O A:THR142 2.7 66.2 1.0 O B:THR251 2.8 65.0 1.0 OG1 A:THR251 2.9 65.7 1.0 OG1 B:THR142 3.0 66.3 1.0 CB B:THR251 3.4 60.5 1.0 CB A:THR251 3.5 68.5 1.0 CB A:THR142 3.5 66.7 1.0 CB B:THR142 3.5 67.9 1.0 C B:THR251 3.6 65.1 1.0 C B:THR142 3.6 66.8 1.0 C A:THR142 3.6 65.9 1.0 C A:THR251 3.7 68.7 1.0 K B:K403 3.7 61.9 1.0 CA B:THR251 4.1 60.8 1.0 CA A:THR142 4.2 63.2 1.0 CA A:THR251 4.2 64.5 1.0 CA B:THR142 4.2 62.1 1.0 N B:ILE252 4.6 61.4 1.0 CG2 B:THR251 4.7 50.9 1.0 N A:ILE143 4.7 61.2 1.0 N B:ILE143 4.7 64.2 1.0 N A:ILE252 4.7 65.5 1.0 CG2 B:THR142 4.7 64.5 1.0 CG2 A:THR251 4.7 66.2 1.0 CG2 A:THR142 4.8 60.5 1.0 O B:THR250 5.0 70.3 1.0

Potassium binding site 2 out of 3 in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK1 (K2P2.1)


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK1 (K2P2.1) within 5.0Å range: probe atom residue distance (Å) B Occ A:K402 b:0.6 occ:1.00 O A:HOH509 2.8 82.2 1.0 O B:HOH511 3.2 77.5 1.0 O A:HOH510 3.3 92.5 1.0 O B:PHE145 3.4 81.0 1.0 O A:ILE143 3.4 64.1 1.0 N A:GLY146 3.4 73.3 1.0 O B:HOH507 3.7 68.6 1.0 O B:ILE252 3.8 65.3 1.0 O A:ILE252 3.9 75.9 1.0 C A:GLY144 3.9 72.4 1.0 CA A:GLY146 3.9 72.7 1.0 CA A:GLY144 3.9 64.8 1.0 N A:PHE145 4.0 72.8 1.0 K B:K403 4.1 61.9 1.0 CA A:GLY255 4.2 0.4 1.0 N B:PHE145 4.3 73.0 1.0 O B:ILE143 4.4 73.4 1.0 C B:PHE145 4.4 81.1 1.0 C A:ILE143 4.4 65.0 1.0 O A:GLY144 4.4 72.3 1.0 N A:GLY255 4.5 0.9 1.0 C A:PHE145 4.5 78.9 1.0 CA A:GLY253 4.5 81.7 1.0 CA A:PHE145 4.7 74.6 1.0 N A:GLY144 4.7 63.9 1.0 O A:GLY146 4.7 76.5 1.0 C A:GLY253 4.8 94.6 1.0 O A:GLY253 4.8 94.8 1.0 C A:GLY146 4.8 77.1 1.0 CA B:GLY144 4.8 68.8 1.0 C B:GLY144 4.9 75.3 1.0 C A:ILE252 4.9 76.5 1.0 CA B:PHE145 5.0 74.6 1.0

Potassium binding site 3 out of 3 in the Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK1 (K2P2.1)


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK1 (K2P2.1) within 5.0Å range: probe atom residue distance (Å) B Occ B:K403 b:61.9 occ:1.00 O B:ILE143 2.6 73.4 1.0 O B:THR251 2.8 65.0 1.0 O B:ILE252 2.9 65.3 1.0 O B:THR142 2.9 66.3 1.0 O A:ILE252 3.0 75.9 1.0 O A:ILE143 3.0 64.1 1.0 O A:THR251 3.0 68.9 1.0 O A:THR142 3.1 66.2 1.0 C B:ILE143 3.3 72.3 1.0 C B:ILE252 3.5 65.1 1.0 C A:ILE252 3.6 76.5 1.0 K A:K401 3.7 64.1 1.0 C A:ILE143 3.7 65.0 1.0 C B:THR251 3.9 65.1 1.0 C B:THR142 4.0 66.8 1.0 CA B:ILE143 4.0 65.2 1.0 N B:GLY144 4.0 68.6 1.0 CA A:ILE252 4.1 65.8 1.0 K A:K402 4.1 0.6 1.0 CA B:ILE252 4.1 60.2 1.0 C A:THR251 4.1 68.7 1.0 C A:THR142 4.2 65.9 1.0 CA B:GLY144 4.2 68.8 1.0 CA A:ILE143 4.3 59.8 1.0 N B:GLY253 4.4 62.5 1.0 N B:ILE143 4.4 64.2 1.0 N A:GLY253 4.4 78.8 1.0 N A:GLY144 4.5 63.9 1.0 N B:ILE252 4.5 61.4 1.0 N A:ILE252 4.6 65.5 1.0 CA B:GLY253 4.7 63.2 1.0 N A:ILE143 4.7 61.2 1.0 CA A:GLY144 4.8 64.8 1.0 O A:HOH509 4.8 82.2 1.0 CA A:GLY253 4.9 81.7 1.0

A.C.W.Pike, Y.Y.Dong, A.Tessitore, S.Goubin, C.Strain-Damerell, S.Mukhopadhyay, K.Kupinska, D.Wang, R.Chalk, G.Berridge, M.Grieben, L.Shrestha, J.H.Ang, A.Mackenzie, A.Quigley, S.R.Bushell, C.A.Shintre, B.Faust, A.Chu, L.Dong, F.Von Delft, C.H.Arrowsmith, A.M.Edwards, C.Bountra, N.A.Burgess-Brown, E.P.Carpenter. Crystal Structure of Human Two Pore Domain Potassium Ion Channel TREK1 (K2P2.1) To Be Published.