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Potassium in PDB 4rue: Human K2P4.1 (Traak) Potassium Channel, G124I Mutant

Protein crystallography data

The structure of Human K2P4.1 (Traak) Potassium Channel, G124I Mutant, PDB code: 4rue was solved by M.Lolicato, D.L.Jr.Minor, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 14.99 / 3.30
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 87.490, 118.697, 128.701, 90.00, 90.00, 90.00
R / Rfree (%) 29.1 / 32.3

Potassium Binding Sites:

The binding sites of Potassium atom in the Human K2P4.1 (Traak) Potassium Channel, G124I Mutant (pdb code 4rue). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 6 binding sites of Potassium where determined in the Human K2P4.1 (Traak) Potassium Channel, G124I Mutant, PDB code: 4rue:
Jump to Potassium binding site number: 1; 2; 3; 4; 5; 6;

Potassium binding site 1 out of 6 in 4rue

Go back to Potassium Binding Sites List in 4rue
Potassium binding site 1 out of 6 in the Human K2P4.1 (Traak) Potassium Channel, G124I Mutant


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Human K2P4.1 (Traak) Potassium Channel, G124I Mutant within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K401

b:0.1
occ:1.00
 O B:THR238 2.7 0.7 1.0
O A:THR238 2.8 0.7 1.0
K B:K401 2.8 0.3 1.0
O A:ILE130 2.8 0.1 1.0
O B:ILE130 2.8 0.9 1.0
O A:VAL239 2.8 0.8 1.0
O A:THR129 2.8 1.0 1.0
O B:THR129 2.8 0.9 1.0
O B:VAL239 2.9 0.2 1.0
C A:VAL239 3.4 0.1 1.0
C B:VAL239 3.5 0.9 1.0
C A:ILE130 3.5 0.3 1.0
C B:ILE130 3.5 0.3 1.0
C A:THR238 3.8 0.8 1.0
C B:THR238 3.8 0.7 1.0
C A:THR129 3.9 0.5 1.0
CA A:VAL239 3.9 0.4 1.0
C B:THR129 3.9 0.8 1.0
K A:K402 3.9 0.9 1.0
CA B:VAL239 4.0 1.0 1.0
CA A:ILE130 4.0 0.2 1.0
CA B:ILE130 4.1 0.9 1.0
N B:GLY240 4.3 0.7 1.0
N A:GLY240 4.3 0.5 1.0
N A:VAL239 4.3 0.8 1.0
N B:VAL239 4.4 0.3 1.0
N A:ILE130 4.4 0.5 1.0
N B:GLY131 4.5 0.6 1.0
N B:ILE130 4.5 0.5 1.0
N A:GLY131 4.5 0.8 1.0
CA B:GLY240 4.6 0.4 1.0
CA A:GLY240 4.6 0.4 1.0
O A:GLY131 4.7 0.8 1.0
O B:GLY131 4.7 0.2 1.0
CA B:GLY131 4.8 0.3 1.0
O A:GLY240 4.8 0.5 1.0
O B:GLY240 4.9 0.5 1.0
CA A:GLY131 4.9 0.8 1.0
CA A:THR238 5.0 0.3 1.0

Potassium binding site 2 out of 6 in 4rue

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Potassium binding site 2 out of 6 in the Human K2P4.1 (Traak) Potassium Channel, G124I Mutant


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Human K2P4.1 (Traak) Potassium Channel, G124I Mutant within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K402

b:0.9
occ:1.00
 OG1 B:THR238 2.9 0.8 1.0
OG1 A:THR238 2.9 1.0 1.0
O A:THR238 2.9 0.7 1.0
OG1 A:THR129 2.9 0.8 1.0
O A:THR129 3.0 1.0 1.0
OG1 B:THR129 3.0 0.5 1.0
O B:THR129 3.0 0.9 1.0
O B:THR238 3.1 0.7 1.0
CB A:THR129 3.4 0.2 1.0
CB A:THR238 3.4 0.4 1.0
CB B:THR129 3.4 0.4 1.0
CB B:THR238 3.5 0.5 1.0
C A:THR238 3.8 0.8 1.0
C A:THR129 3.8 0.5 1.0
C B:THR129 3.9 0.8 1.0
C B:THR238 3.9 0.7 1.0
K A:K401 3.9 0.1 1.0
CA A:THR129 4.3 0.4 1.0
CA A:THR238 4.3 0.3 1.0
CA B:THR129 4.3 0.8 1.0
CA B:THR238 4.4 0.1 1.0
K A:K403 4.4 0.4 1.0
CG2 A:THR129 4.6 0.3 1.0
CG2 B:THR238 4.6 0.5 1.0
CG2 B:THR129 4.6 0.7 1.0
CG2 A:THR238 4.6 0.1 1.0
O A:THR237 4.8 0.6 1.0
O B:THR237 4.8 0.8 1.0
N A:VAL239 4.9 0.8 1.0
N B:ILE130 4.9 0.5 1.0
N A:ILE130 4.9 0.5 1.0
O B:THR128 4.9 0.0 1.0
N B:VAL239 4.9 0.3 1.0
O A:THR128 5.0 0.9 1.0

Potassium binding site 3 out of 6 in 4rue

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Potassium binding site 3 out of 6 in the Human K2P4.1 (Traak) Potassium Channel, G124I Mutant


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Human K2P4.1 (Traak) Potassium Channel, G124I Mutant within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K403

b:0.4
occ:1.00
 OG1 B:THR129 4.4 0.5 1.0
OG1 A:THR238 4.4 1.0 1.0
K A:K402 4.4 0.9 1.0
OG1 A:THR129 4.6 0.8 1.0
OG1 B:THR238 4.8 0.8 1.0

Potassium binding site 4 out of 6 in 4rue

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Potassium binding site 4 out of 6 in the Human K2P4.1 (Traak) Potassium Channel, G124I Mutant


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Human K2P4.1 (Traak) Potassium Channel, G124I Mutant within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K404

b:0.4
occ:1.00
 NH1 A:ARG138 4.5 0.4 1.0

Potassium binding site 5 out of 6 in 4rue

Go back to Potassium Binding Sites List in 4rue
Potassium binding site 5 out of 6 in the Human K2P4.1 (Traak) Potassium Channel, G124I Mutant


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 5 of Human K2P4.1 (Traak) Potassium Channel, G124I Mutant within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K405

b:0.8
occ:1.00
 O A:GLY240 2.7 0.5 1.0
O B:GLY240 2.8 0.5 1.0
O B:GLY131 2.8 0.2 1.0
O B:TYR132 2.9 0.5 1.0
O A:TYR132 2.9 0.3 1.0
K B:K401 3.0 0.3 1.0
O A:GLY131 3.0 0.8 1.0
O A:PHE241 3.4 0.4 1.0
C B:TYR132 3.5 0.7 1.0
O B:PHE241 3.5 0.2 1.0
C A:TYR132 3.6 0.5 1.0
C A:PHE241 3.8 0.3 1.0
C B:PHE241 3.9 0.7 1.0
C A:GLY240 3.9 0.7 1.0
C B:GLY240 4.0 0.5 1.0
C B:GLY131 4.0 0.1 1.0
CA A:PHE241 4.1 0.0 1.0
CA B:TYR132 4.1 0.6 1.0
CA A:TYR132 4.2 0.0 1.0
C A:GLY131 4.2 0.8 1.0
N B:GLY133 4.2 0.8 1.0
CA B:PHE241 4.3 0.5 1.0
N A:GLY133 4.4 0.9 1.0
N A:PHE241 4.5 0.3 1.0
CA B:GLY133 4.5 0.9 1.0
N B:GLY242 4.5 0.1 1.0
N A:GLY242 4.5 0.3 1.0
N B:TYR132 4.5 0.6 1.0
N B:PHE241 4.6 0.3 1.0
N A:TYR132 4.7 0.2 1.0
CA A:GLY133 4.8 0.9 1.0
CA B:GLY242 4.9 0.9 1.0
O A:VAL239 4.9 0.8 1.0
CA A:GLY242 5.0 0.6 1.0
O B:VAL239 5.0 0.2 1.0

Potassium binding site 6 out of 6 in 4rue

Go back to Potassium Binding Sites List in 4rue
Potassium binding site 6 out of 6 in the Human K2P4.1 (Traak) Potassium Channel, G124I Mutant


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 6 of Human K2P4.1 (Traak) Potassium Channel, G124I Mutant within 5.0Å range:
probe atom residue distance (Å) B Occ
B:K401

b:0.3
occ:1.00
 O A:GLY131 2.7 0.8 1.0
O B:GLY131 2.7 0.2 1.0
O B:GLY240 2.7 0.5 1.0
O A:VAL239 2.7 0.8 1.0
O A:GLY240 2.8 0.5 1.0
O B:VAL239 2.8 0.2 1.0
K A:K401 2.8 0.1 1.0
O B:ILE130 2.8 0.9 1.0
O A:ILE130 2.8 0.1 1.0
K A:K405 3.0 0.8 1.0
C B:GLY240 3.5 0.5 1.0
C A:GLY240 3.5 0.7 1.0
C B:GLY131 3.6 0.1 1.0
C A:GLY131 3.6 0.8 1.0
C B:VAL239 3.8 0.9 1.0
C A:VAL239 3.8 0.1 1.0
CA B:GLY240 3.8 0.4 1.0
CA A:GLY240 3.9 0.4 1.0
C B:ILE130 3.9 0.3 1.0
C A:ILE130 4.0 0.3 1.0
CA B:GLY131 4.1 0.3 1.0
CA A:GLY131 4.2 0.8 1.0
N B:GLY240 4.2 0.7 1.0
N A:GLY240 4.3 0.5 1.0
N B:GLY131 4.5 0.6 1.0
N B:PHE241 4.5 0.3 1.0
N A:GLY131 4.6 0.8 1.0
N A:PHE241 4.6 0.3 1.0
N B:TYR132 4.6 0.6 1.0
N A:TYR132 4.6 0.2 1.0
CA B:TYR132 4.9 0.6 1.0
CA A:TYR132 4.9 0.0 1.0
O B:THR238 5.0 0.7 1.0
CA B:PHE241 5.0 0.5 1.0

Reference:

M.Lolicato, P.M.Riegelhaupt, C.Arrigoni, K.A.Clark, D.L.Jr.Minor. Transmembrane Helix Straightening and Buckling Underlies Activation of Mechanosensitive and Thermosensitive K2P Channels Neuron 2014.
ISSN: ISSN 0896-6273
Page generated: Mon Aug 12 12:03:10 2024

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