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Atomistry » Potassium » PDB 4pkl-4qrh » 4qfc | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Potassium » PDB 4pkl-4qrh » 4qfc » |
Potassium in PDB 4qfc: Co-Crystal Structure of Compound 3 (4-Hydroxy-6-[2-(7-Hydroxy-2-Oxo-4- Phenyl-2H-Chromen-6-Yl)Ethyl]Pyridazin-3(2H)-One) and Fad Bound to Human Daao at 2.4AEnzymatic activity of Co-Crystal Structure of Compound 3 (4-Hydroxy-6-[2-(7-Hydroxy-2-Oxo-4- Phenyl-2H-Chromen-6-Yl)Ethyl]Pyridazin-3(2H)-One) and Fad Bound to Human Daao at 2.4A
All present enzymatic activity of Co-Crystal Structure of Compound 3 (4-Hydroxy-6-[2-(7-Hydroxy-2-Oxo-4- Phenyl-2H-Chromen-6-Yl)Ethyl]Pyridazin-3(2H)-One) and Fad Bound to Human Daao at 2.4A:
1.4.3.3; Protein crystallography data
The structure of Co-Crystal Structure of Compound 3 (4-Hydroxy-6-[2-(7-Hydroxy-2-Oxo-4- Phenyl-2H-Chromen-6-Yl)Ethyl]Pyridazin-3(2H)-One) and Fad Bound to Human Daao at 2.4A, PDB code: 4qfc
was solved by
C.M.Lukacs,
L.Chun,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Potassium Binding Sites:
The binding sites of Potassium atom in the Co-Crystal Structure of Compound 3 (4-Hydroxy-6-[2-(7-Hydroxy-2-Oxo-4- Phenyl-2H-Chromen-6-Yl)Ethyl]Pyridazin-3(2H)-One) and Fad Bound to Human Daao at 2.4A
(pdb code 4qfc). This binding sites where shown within
5.0 Angstroms radius around Potassium atom.
In total only one binding site of Potassium was determined in the Co-Crystal Structure of Compound 3 (4-Hydroxy-6-[2-(7-Hydroxy-2-Oxo-4- Phenyl-2H-Chromen-6-Yl)Ethyl]Pyridazin-3(2H)-One) and Fad Bound to Human Daao at 2.4A, PDB code: 4qfc: Potassium binding site 1 out of 1 in 4qfcGo back to Potassium Binding Sites List in 4qfc
Potassium binding site 1 out
of 1 in the Co-Crystal Structure of Compound 3 (4-Hydroxy-6-[2-(7-Hydroxy-2-Oxo-4- Phenyl-2H-Chromen-6-Yl)Ethyl]Pyridazin-3(2H)-One) and Fad Bound to Human Daao at 2.4A
Mono view Stereo pair view
Reference:
R.T.Terry-Lorenzo,
L.E.Chun,
S.P.Brown,
M.L.Heffernan,
Q.K.Fang,
M.A.Orsini,
L.Pollegioni,
L.W.Hardy,
K.L.Spear,
T.H.Large.
Novel Human D-Amino Acid Oxidase Inhibitors Stabilize An Active Site Lid Open Conformation. Biosci.Rep. 2014.
Page generated: Sun Dec 13 23:48:25 2020
ISSN: ISSN 0144-8463 PubMed: 25001371 DOI: 10.1042/BSR20140071 |
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