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Potassium in PDB 4kfm: Crystal Structure of the G Protein-Gated Inward Rectifier K+ Channel GIRK2 (KIR3.2) in Complex with the Beta-Gamma G Protein Subunits

Protein crystallography data

The structure of Crystal Structure of the G Protein-Gated Inward Rectifier K+ Channel GIRK2 (KIR3.2) in Complex with the Beta-Gamma G Protein Subunits, PDB code: 4kfm was solved by M.R.Whorton, R.Mackinnon, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 49.89 / 3.45
Space group I 4 2 2
Cell size a, b, c (Å), α, β, γ (°) 127.308, 127.308, 309.392, 90.00, 90.00, 90.00
R / Rfree (%) 22.8 / 26.5

Other elements in 4kfm:

The structure of Crystal Structure of the G Protein-Gated Inward Rectifier K+ Channel GIRK2 (KIR3.2) in Complex with the Beta-Gamma G Protein Subunits also contains other interesting chemical elements:

Sodium (Na) 1 atom

Potassium Binding Sites:

The binding sites of Potassium atom in the Crystal Structure of the G Protein-Gated Inward Rectifier K+ Channel GIRK2 (KIR3.2) in Complex with the Beta-Gamma G Protein Subunits (pdb code 4kfm). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total 5 binding sites of Potassium where determined in the Crystal Structure of the G Protein-Gated Inward Rectifier K+ Channel GIRK2 (KIR3.2) in Complex with the Beta-Gamma G Protein Subunits, PDB code: 4kfm:
Jump to Potassium binding site number: 1; 2; 3; 4; 5;

Potassium binding site 1 out of 5 in 4kfm

Go back to Potassium Binding Sites List in 4kfm
Potassium binding site 1 out of 5 in the Crystal Structure of the G Protein-Gated Inward Rectifier K+ Channel GIRK2 (KIR3.2) in Complex with the Beta-Gamma G Protein Subunits


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of the G Protein-Gated Inward Rectifier K+ Channel GIRK2 (KIR3.2) in Complex with the Beta-Gamma G Protein Subunits within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K402

b:82.8
occ:0.13
K A:K403 3.0 0.2 0.1
O A:GLY156 3.4 0.2 1.0
O A:TYR157 3.6 0.4 1.0
C A:TYR157 4.1 0.2 1.0
C A:GLY156 4.4 0.3 1.0
CA A:TYR157 4.5 0.2 1.0
N A:GLY158 4.8 0.4 1.0
O A:ILE155 4.8 0.4 1.0
N A:TYR157 4.9 0.5 1.0

Potassium binding site 2 out of 5 in 4kfm

Go back to Potassium Binding Sites List in 4kfm
Potassium binding site 2 out of 5 in the Crystal Structure of the G Protein-Gated Inward Rectifier K+ Channel GIRK2 (KIR3.2) in Complex with the Beta-Gamma G Protein Subunits


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 2 of Crystal Structure of the G Protein-Gated Inward Rectifier K+ Channel GIRK2 (KIR3.2) in Complex with the Beta-Gamma G Protein Subunits within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K403

b:0.2
occ:0.13
K A:K404 2.8 78.8 0.1
O A:ILE155 3.0 0.4 1.0
K A:K402 3.0 82.8 0.1
O A:GLY156 3.7 0.2 1.0
C A:ILE155 4.2 0.7 1.0
C A:GLY156 4.3 0.3 1.0
CA A:GLY156 4.8 0.6 1.0
O A:THR154 4.9 0.5 1.0
N A:GLY156 5.0 0.3 1.0

Potassium binding site 3 out of 5 in 4kfm

Go back to Potassium Binding Sites List in 4kfm
Potassium binding site 3 out of 5 in the Crystal Structure of the G Protein-Gated Inward Rectifier K+ Channel GIRK2 (KIR3.2) in Complex with the Beta-Gamma G Protein Subunits


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 3 of Crystal Structure of the G Protein-Gated Inward Rectifier K+ Channel GIRK2 (KIR3.2) in Complex with the Beta-Gamma G Protein Subunits within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K404

b:78.8
occ:0.13
K A:K403 2.8 0.2 0.1
O A:THR154 2.9 0.5 1.0
K A:K405 3.3 91.9 0.1
O A:ILE155 3.5 0.4 1.0
C A:THR154 4.1 0.9 1.0
C A:ILE155 4.2 0.7 1.0
CA A:ILE155 4.3 0.8 1.0
N A:ILE155 4.7 0.0 1.0
OG1 A:THR154 4.8 97.5 1.0

Potassium binding site 4 out of 5 in 4kfm

Go back to Potassium Binding Sites List in 4kfm
Potassium binding site 4 out of 5 in the Crystal Structure of the G Protein-Gated Inward Rectifier K+ Channel GIRK2 (KIR3.2) in Complex with the Beta-Gamma G Protein Subunits


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 4 of Crystal Structure of the G Protein-Gated Inward Rectifier K+ Channel GIRK2 (KIR3.2) in Complex with the Beta-Gamma G Protein Subunits within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K405

b:91.9
occ:0.13
OG1 A:THR154 2.9 97.5 1.0
O A:THR154 3.1 0.5 1.0
K A:K404 3.3 78.8 0.1
CB A:THR154 4.0 0.1 1.0
C A:THR154 4.2 0.9 1.0
CA A:THR154 4.7 0.5 1.0
O A:THR153 4.8 96.8 1.0

Potassium binding site 5 out of 5 in 4kfm

Go back to Potassium Binding Sites List in 4kfm
Potassium binding site 5 out of 5 in the Crystal Structure of the G Protein-Gated Inward Rectifier K+ Channel GIRK2 (KIR3.2) in Complex with the Beta-Gamma G Protein Subunits


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 5 of Crystal Structure of the G Protein-Gated Inward Rectifier K+ Channel GIRK2 (KIR3.2) in Complex with the Beta-Gamma G Protein Subunits within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K406

b:0.1
occ:0.25
OE2 A:GLU236 4.2 0.3 1.0

Reference:

M.R.Whorton, R.Mackinnon. X-Ray Structure of the Mammalian GIRK2-Beta Gamma G-Protein Complex. Nature V. 498 190 2013.
ISSN: ISSN 0028-0836
PubMed: 23739333
DOI: 10.1038/NATURE12241
Page generated: Mon Aug 12 11:11:40 2024

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