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Potassium in PDB 4ikr: Crystal Structure of Type 1 Human Methionine Aminopeptidase in Complex with 2-(4-(5-Chloro-6-Methyl-2-(Pyridin-2-Yl)Pyrimidin-4-Yl) Piperazin-1-Yl)Ethanol

Enzymatic activity of Crystal Structure of Type 1 Human Methionine Aminopeptidase in Complex with 2-(4-(5-Chloro-6-Methyl-2-(Pyridin-2-Yl)Pyrimidin-4-Yl) Piperazin-1-Yl)Ethanol

All present enzymatic activity of Crystal Structure of Type 1 Human Methionine Aminopeptidase in Complex with 2-(4-(5-Chloro-6-Methyl-2-(Pyridin-2-Yl)Pyrimidin-4-Yl) Piperazin-1-Yl)Ethanol:
3.4.11.18;

Protein crystallography data

The structure of Crystal Structure of Type 1 Human Methionine Aminopeptidase in Complex with 2-(4-(5-Chloro-6-Methyl-2-(Pyridin-2-Yl)Pyrimidin-4-Yl) Piperazin-1-Yl)Ethanol, PDB code: 4ikr was solved by A.Addlagatta, C.Kishor, T.Arya, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 40.39 / 1.78
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 47.345, 77.423, 48.023, 90.00, 91.03, 90.00
R / Rfree (%) 18 / 21.1

Other elements in 4ikr:

The structure of Crystal Structure of Type 1 Human Methionine Aminopeptidase in Complex with 2-(4-(5-Chloro-6-Methyl-2-(Pyridin-2-Yl)Pyrimidin-4-Yl) Piperazin-1-Yl)Ethanol also contains other interesting chemical elements:

Cobalt (Co) 3 atoms
Chlorine (Cl) 1 atom

Potassium Binding Sites:

The binding sites of Potassium atom in the Crystal Structure of Type 1 Human Methionine Aminopeptidase in Complex with 2-(4-(5-Chloro-6-Methyl-2-(Pyridin-2-Yl)Pyrimidin-4-Yl) Piperazin-1-Yl)Ethanol (pdb code 4ikr). This binding sites where shown within 5.0 Angstroms radius around Potassium atom.
In total only one binding site of Potassium was determined in the Crystal Structure of Type 1 Human Methionine Aminopeptidase in Complex with 2-(4-(5-Chloro-6-Methyl-2-(Pyridin-2-Yl)Pyrimidin-4-Yl) Piperazin-1-Yl)Ethanol, PDB code: 4ikr:

Potassium binding site 1 out of 1 in 4ikr

Go back to Potassium Binding Sites List in 4ikr
Potassium binding site 1 out of 1 in the Crystal Structure of Type 1 Human Methionine Aminopeptidase in Complex with 2-(4-(5-Chloro-6-Methyl-2-(Pyridin-2-Yl)Pyrimidin-4-Yl) Piperazin-1-Yl)Ethanol


Mono view


Stereo pair view

A full contact list of Potassium with other atoms in the K binding site number 1 of Crystal Structure of Type 1 Human Methionine Aminopeptidase in Complex with 2-(4-(5-Chloro-6-Methyl-2-(Pyridin-2-Yl)Pyrimidin-4-Yl) Piperazin-1-Yl)Ethanol within 5.0Å range:
probe atom residue distance (Å) B Occ
A:K405

b:16.8
occ:1.00
 O A:VAL209 2.6 13.7 1.0
O A:SER363 2.7 16.3 1.0
O A:HOH506 2.8 14.2 1.0
O A:ASN207 2.8 17.4 1.0
O A:SER205 2.9 13.9 1.0
N A:ASN207 3.5 16.9 1.0
C A:SER205 3.6 14.3 1.0
C A:ASN207 3.7 16.2 1.0
C A:VAL206 3.7 16.1 1.0
C A:SER363 3.8 16.1 1.0
C A:VAL209 3.8 13.2 1.0
O A:VAL206 4.0 15.9 1.0
CA A:ASN207 4.0 17.5 1.0
CB A:SER205 4.2 14.4 1.0
N A:VAL206 4.2 15.2 1.0
CA A:VAL206 4.3 16.1 1.0
N A:VAL209 4.3 14.2 1.0
N A:SER363 4.5 16.2 1.0
CA A:SER205 4.5 13.6 1.0
CA A:SER363 4.5 15.6 1.0
CA A:VAL209 4.5 13.7 1.0
O A:HOH505 4.5 14.7 1.0
CB A:SER363 4.5 16.3 1.0
N A:ALA364 4.7 15.3 1.0
CG1 A:ILE225 4.7 18.0 1.0
CA A:ALA364 4.7 15.3 1.0
N A:GLU208 4.8 15.6 1.0
CB A:VAL209 4.8 13.8 1.0
O A:ILE225 4.8 19.5 1.0
N A:ILE210 4.8 12.6 1.0
CD1 A:ILE225 4.9 19.3 1.0
C A:GLU208 4.9 15.0 1.0
N A:ASN227 5.0 14.0 1.0
O A:HOH536 5.0 10.6 1.0
CB A:ASN227 5.0 13.5 1.0
CA A:ILE210 5.0 12.6 1.0

Reference:

C.Kishor, T.Arya, R.Reddi, X.Chen, V.Saddanapu, A.K.Marapaka, R.Gumpena, D.Ma, J.O.Liu, A.Addlagatta. Identification, Biochemical and Structural Evaluation of Species-Specific Inhibitors Against Type I Methionine Aminopeptidases J.Med.Chem. V. 56 5295 2013.
ISSN: ISSN 0022-2623
PubMed: 23767698
DOI: 10.1021/JM400395P
Page generated: Mon Aug 12 11:01:41 2024

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